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Biomedical subjects

T C Merigan

Publications and source records attributed to T C Merigan.

At least 379 records · Page 21Linked to original sources
PubMed1968

Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii).

Chick and mouse cell monolayers treated with interferon were significantly protected from destruction by toxoplasma. The results suggest that fewer numbers of organisms were released from interferon-treated cells. Interferons were uniformly more active in a viral assay than in a toxoplasma assay, and they had the same properties in both assays. The data suggest that interferon activity may be directed against organisms phylogenetically higher than viruses.

Animals↗
PubMed1968

Interferon inducers in vitro: difference in sensitivity to inhbitiros of RNA and protein synthesis.

Interferon can be induced by diverse agents in a variety of mammalian cell cultures through apparently two mechanisms. One results in an early (2 to 10 hours) appearance of interferon and is relatively resistant to inhibition by actinomycin, puromycin, or fluorophenylalanine. A second mechanism results in a late (18 to 24 hours) appearance of interferon and is more sensitive to inhibition by these inhibitors. The molecular basis for each mechanism is unclear. Since each interferon inducer may have multiple effects on the cell, the differences observed may not necessarily reflect a fundamental difference in the mechanism of interferon stimulation.

Carbon Isotopes↗