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Biomedical subjects

T C Jou

Publications and source records attributed to T C Jou.

18 recordsLinked to original sources
PubMed1990

Inhibitory effect of octopamine on dopamine D-1 receptor in striatal homogenates of the rat.

In the striatal homogenates of rats, octopamine produced a dose-dependent inhibition of dopamine D-1 receptor both in the receptor binding of [3H]Sch-23390 and the formation of cyclic adenosine 3',5'-monophosphate (cyclic AMP) stimulated by dopamine in the presence of sulpiride. Failure of octopamine in the displacement of binding with [3H]N-0437, one of the radioligands for the dopamine D-2 receptor, indicated the specific selectivity of octopamine to dopamine D-1 receptor sites. Lack of effect on forskolin-stimulated formation of cyclic AMP ruled out the possible direct effect of octopamine on adenylate cyclase. These results suggest that octopamine possesses the ability to bind to striatal dopamine D-1 receptors of rats.

Adenylyl Cyclase Inhibitors↗
PubMed1988

Inhibitory effect of l-ascorbic acid on the growth of astrocytes in cell culture.

The effect of l-ascorbic acid on the growth of astrocytic cells in culture was investigated. l-Ascorbic acid produced a concentration-dependent reduction of the growth of astrocytes, both in normal and tumor cells. The effect of l-ascorbic acid was similar to that of the relative acidification of the medium, except in treated concentrations greater than 10(-6) M. The effects produced by both l- and d-forms of ascorbic acid were the same. The inhibitory effect of l-ascorbic acid at greater concentrations was partially prevented by oxidized glutathione and increased by the large concentration of reduced glutathione. This result suggests that l-ascorbic acid possesses the ability to inhibit the growth of astrocytic cells in culture through the acidification of the medium at small concentrations and/or the antioxidative properties of this compound at larger concentrations.

Animals↗
PubMed1987

Ethanol effects on phospholipids and triacylglycerols of rat brain astrocyte cell line.

A homotypic population of rat brain astrocyte (RBA-1) cell line was used to investigate the effects of ethanol on uptake of [3H]-arachidonic acid and incorporation of label into phospholipids and neutral lipids in the cell. Incubation of the cells with [3H]-arachidonic acid resulted in labeling of most phospholipids and triacylglycerols, although individual phospholipids exhibited different rates for acquiring the label. Labeled arachidonate was first incorporated into phosphatidylcholines and phosphatidylinositols prior to equilibriation with other phospholipids. In short term incubation (8 hr), ethanol (128-255 mM) enhanced the incorporation of labeled arachidonate into most phospholipids. In addition, ethanol at 128 mM enhanced the labeling of the triacylglycerols, and the difference was greater with increasing time of ethanol exposure. It is concluded that ethanol enhanced the uptake and incorporation of polyunsaturated fatty acids into the cell membrane lipids. This study further indicates the feasibility of using the RBA-1 cells in culture to probe the effects of ethanol on membrane lipid metabolism.

Animals↗
PubMed1984

Double balanced de novo translocations involving chromosomes 4/15 and 5/12 in a mentally retarded boy.

This report describes a compound structural rearrangement containing two apparently unrelated reciprocal translocations, one between chromosomes 4 and 15, the other between 5 and 12. It is suggested that the patient's mental retardation and osteosclerosis may be the result of the loss of a small amount of chromosomal material and/or position effect accompanying these translocations.

Adolescent↗
PubMed1967

Pinocytosis.

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Culture Techniques↗