The Klebsiella-Enterobacter-Serratia division. Biochemical and serologic characteristics and susceptibility to antibiotics.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to T C Eickhoff.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A clinical trial was designed for evaluation of the efficacy, safety, and patient tolerance of cefoxitin. Of 26 patients who could be evaluated clinically, 21 had respiratory tract infections; all but one patient responded satisfactorily to therapy with cefoxitin. There were no adverse systemic reactions, nor was any renal or hematologic toxicity noted. In two instances levels of hepatic enzymes became slightly elevated; these changes were possibly related to administration of cefoxitin. About one-third of patients receiving cefoxitin developed minor local reactions at the site of intravenous administration; however, there was only a single instance of true thrombophlebitis. Results of this study suggest that cefoxitin is a safe and well-tolerated antibiotic that is efficacious in therapy of acute respiratory tract infections caused by bacteria that are sensitive to this drug.
During January, 1976 seven patients in an SICU became colonized or infected with Acinetobacter calcoaceticus (variation, anitratum) at an attack rate of 12.5 per cent. The organism showed a marked reduction in antimicrobial sensitivity from previous experience. Comparison with 34 uninfected control patients indicated that intubation and continuous ventilatory assistance were significantly associated with acquiring the organism (p = 0.0154). Acinetobacter was cultured from nurses' hands, AMBU adaptors, respirator apparatus, respirometers, and unlabeled bottles of saline used for tracheal irrigation. Control measures were designed to interrupt transmission. The investigation identified the nursing techniques and reservoirs that allowed this outbreak to occur, and we emphasize the need for close surveillance of patient care procedures in an intensive care unit.