Search PubMed⌕ Search

Biomedical subjects

T C Brown

Publications and source records attributed to T C Brown.

At least 91 records · Page 5Linked to original sources
PubMed1985

Prognostic groups for management of localized Hodgkin's disease.

Two hundred fifty-two patients receiving radical irradiation for clinical stages I and II Hodgkin's disease between 1968 to 1977 had an actuarial ten-year survival rate of 78% and a relapse-free rate of 61%. Sixty-seven patients receiving chemotherapy followed by radiation had a 78% survival rate and a 63% relapse-free rate. Independent prognostic factors for survival and relapse were age, stage, and histology. Disease bulk was predictive only of relapse. Neither site of presentation above or below the diaphragm nor presence of mediastinal involvement was predictive for survival or relapse; however, patients with large mediastinal masses (greater than or equal to 10 cm absolute diameter) had a significantly higher intrathoracic failure rate with conventional mantle irradiation. Analysis of failure, according to age, clinical stage, and histologic type, showed three groups of patients defined according to the risk of relapse with radiation therapy: those with isolated upper cervical stage IA disease (group 1, relapse rate 8%), younger patients with localized stages I and II disease of favorable histologic type (group 2, relapse rate 35%), and older patients with extensive or symptomatic stages I and II disease of less favorable histologic type (group 3, relapse rate 70%). Subsequent analysis of radiation treatment volume indicates that the use of upper abdominal irradiation for patients in group No. 2 could yield results equivalent to those achieved with radiation therapy for surgically staged patients.

Adolescent↗
PubMed1984

Prognostic factors in nodular lymphomas: a multivariate analysis based on the Princess Margaret Hospital experience.

A total of 1,394 patients with non-Hodgkin's lymphoma were treated at the Princess Margaret Hospital between January 1, 1967 and December 31, 1978. Overall actuarial survival of 525 patients with nodular lymphomas was 40% at 12 years; survival of patients with localized (Stage I & III) nodular lymphomas treated with radical radiation therapy was 58%. Significant prognostic factors defined by multivariate analysis included patient's age, stage, histology, tumor bulk, and presence of B symptoms. By combining prognostic factors we have identified distinct prognostic groups within the overall population. Patients with Stage I & II disease, small or medium bulk, less than 70 years of age achieved 92% 12 year actuarial survival and a 73% relapse-free rate in 12 years of follow-up. These patients represent groups highly curable with irradiation.

Adolescent↗
PubMed1984

Esophageal anastomosis--an experimental model to study the anastomotic lumen and the influence of a transanastomotic tube.

The influence of an indwelling transanastomotic silicon tube on healing esophageal anastomosis in puppies was studied by making resin casts of the reconstructed esophagus. These casts demonstrated stenosis but no difference in the group with a transanastomotic tube was seen. Stenotic index of the puppies varied from 0.7 to 0.97 (no stenosis = 1). An important observation made during the study was the presence of shelfing of scar tissue on the posterior esophageal wall. This was the site of mucosal ulceration, granuloma formation, and fibrous scarring where interrupted 0000 silk knots had been tied intraluminally. The anterior wall had a linear scar, where the knots were tied extraluminally. Extraluminal knots would be part of the technique to achieve a minimal amount of scar tissue at the site of the esophageal anastomosis.

Animals↗
PubMed1984

Nerve blocks around the knee in children.

Analgesia below the knee can be achieved by blocking the tibial nerve and the common peroneal nerve in the popliteal fossa, and the saphenous nerve adjacent to the knee. The anatomy and technique of nerve block in the popliteal fossa is described, the nerve being located prior to blockade using a peripheral nerve stimulator. The block as described has been used in children for postoperative analgesia, as a diagnostic block, and as an adjunct to the physiotherapy management of severe equinus deformity after brain injury.

Child↗
PubMed1983

Inhaled foreign bodies in children.

We review a series of 115 children who attended the Royal Children's Hospital in Melbourne between 1979 and 1982 with the diagnosis of inhalation of a foreign body, or in whom a foreign body was found at bronchoscopy. Children between the ages of one and three years were the most commonly affected (75%) and boys outnumbered girls in the ratio 3:2. In 16% of cases the child did not present until more than one week after inhaling the foreign body. A peanut was the most common foreign body found (52% of cases), and it seems that many parents are still unaware that peanut ingestion can be hazardous in very young children.

Anesthesia↗
PubMed1983

Plasma bupivacaine concentrations in children during caudal epidural analgesia.

Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 microgram/ml were reached, which are well within the limits of projected toxic levels. Simultaneous arterial and venous sampling showed a small but significant difference between these two sampling sites fo the first fifteen minutes.

Age Factors↗
PubMed1983

Plasma lignocaine concentrations following topical laryngeal application.

Lignocaine 4%, 4 mg/kg, was sprayed onto the larynx and subglottic area of 96 children aged from 2 weeks to 12 years and plasma lignocaine concentrations were measured. While the majority were well within the accepted safe range (4.5 micrograms/ml) occasional concentrations over 8 micrograms/ml appeared in all groups. Simultaneous arterial and venous sampling showed a small but significant difference in the first 10 minutes.

Administration, Topical↗
PubMed1983

Femoral nerve block--the anatomical basis for a single injection technique.

A technique for blocking the femoral nerve using a single needle placement is described. It depends on an appreciation of the anatomy and the need to feel loss of resistance twice as two fascial layers are penetrated during insertion of the needle just lateral to the femoral artery. A single injection of bupivacaine 0.35-0.5 per cent of at least 0.3 ml/kg will produce a satisfactory block.

Bupivacaine↗
PubMed1983

Anaesthesia and the mucopolysaccharidoses: a survey of techniques and problems.

Mucopolysaccharide infiltration of tissues in Hurler, Hunter, San Filippo, Maroteaux-Lamy, Morquio and Scheie syndromes causes problems to anaesthetists in the management of the airway and in myocardial function. Recent experience at the Royal Children's Hospital, Melbourne, is presented with illustrations highlighting these problems.

Adolescent↗