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Biomedical subjects

T Burger

Publications and source records attributed to T Burger.

At least 55 records · Page 3Linked to original sources
PubMed1985

Serum beta-2 microglobulin in chronic lymphocytic leukaemia.

Serum-beta-2-microglobulin was measured by radioimmunoassay in 25 patients with chronic lymphocellular leukaemia in stages III-IV according to the Rai classification. A significant positive correlation was found between the absolute lymphocyte count and the serum-beta-2-microglobulin level. No similar relationship was observed between the score indicative of organ infiltration and the beta-2-microglobulin valve. On the evidence of the results, the increased production of beta-2-microglobulin is attributed in the first place to the circulating lymphocytes. The assay has been found to provide a reliable indicator, suitable for the monitoring and evaluation of therapy.

Aged↗
PubMed1985

Differentiation of glomerular and non-glomerular haematurias on basis of the morphology of urinary red blood cells.

Haematurias present serious problems in differential diagnostics. Although no clear-cut instructions exist, patients with haematuria are usually directed to urological surgeries or inpatient departments. Here they are routinely checked by a number of invasive techniques (cystoscopy, i. v. urography, aortography etc.) before the urological nature of haematuria can be ruled out. The suspicion of a glomerular disease being in the background of haematuria emerges only if it is accompanied by a marked proteinuria. Our department deals with kidney diseases since decades. The routine light microscopic examination of haematuric urinary samples called attention to the fine differences between erythrocyte morphology in glomerular and other haematurias. The present paper is an account of morphological studies of red blood cells carried out in haematuric urinary samples of 120 histologically verified glomerulonephritis and 80 other cases.

Diagnosis, Differential↗
PubMed1984

The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis.

The authors investigated the tubulointerstitial changes (atrophic tubuli, interstitial fibrosis and round-cell infiltration) by two methods in renal biopsies from 56 patients with IgA glomerulonephritis. A statistically significant correlation was found to exist between the tubulointerstitial changes and serum creatinine level at the time of renal biopsy. A statistical significant correlation was also established between serum creatinine at the end of a period of 5 years of follow-up and tubulointerstitial changes. Their results suggest that severe tubulointerstitial lesions in IgA glomerulonephritis carry a poor prognosis.

Adolescent↗
PubMed1984

Herpes virus antigens and antibodies in kidney biopsies and sera of IgA glomerulonephritic patients.

Antibody titers against 4 viruses of the herpes group have been studied in the sera of 54 patients with IgA glomerulonephritis (GN). The incidence of antibodies to herpes simplex virus type-1 (HSV-1), HSV-2, cytomegalovirus (CMV), Epstein-Barr virus nuclear antigen (EBNA), and that of IgG antibodies to EBV virus capsid antigen (VCA) were similar in patients and in controls. However, elevated antibody titers (greater than or equal to 64) to HSV and CMV occurred more frequently in patients with IgA GN than in healthy controls. Geometric mean titers to HSV and CMV were also higher in patients suffering from IgA GN than in controls. The incidence of IgA antibodies to EBV VCA occurred in patients with IgA GN significantly more often than in controls. There was a trace amount of HSV-2 antigen in 2 glomeruli of 1 renal biopsy. It is concluded that, in some patients with IgA GN, there is an abnormal immune response to certain types of herpes viruses.

Adolescent↗
PubMed1984

IgA glomerulonephritis: light microscopic and immunohistological studies.

Renal biopsy material of 50 patients suffering from IgA glomerulonephritis was studied by light microscopy, immunofluorescence and occasionally electron microscopy. Associated with a uniform immunohistological pattern mainly focal or diffuse mesangial proliferative glomerulonephritis was found. In addition to the glomerular changes the importance of frequent extraglomerular, mainly vascular and interstitial, alterations is stressed. In arterioles and arteries, deposition of a hyalinous substance was observed. Immunohistology revealed the presence of immunoglobulins and/or C3 in the vessels. In the interstitium fibrinogen/fibrin was often seen, accompanied by chronic inflammatory infiltration and fibrosis.

Arteries↗
PubMed1984

Plasmapheresis and peritoneal dialysis in the management of rapidly progressive glomerulonephritis.

Six patients with rapidly progressive glomerulonephritis were given plasmapheresis and peritoneal dialysis by manual technique. At the start of treatment the patients were in renal failure and all but two were practically anuric. Renal biopsy revealed glomerular sclerosis in 4 cases. One of the patients in whom segmental focal fibrosis was found, went into remission. In the other three cases extensive hyaline degeneration was present. One of them was placed on a dialysis program, two died with circulatory failure. In two cases no glomerular sclerosis was found, though extensive changes of the tissues were present. One of these patients went into remission, the other died from respiratory failure consequent upon recurrent pneumothorax and gross pulmonary infiltration. The only chance of success in the management of rapidly progressive glomerulonephritis is offered by the earliest possible diagnosis. In cases of glomerular sclerosis the chances are very poor.

Adult↗
PubMed1982

Circulating immune complexes in patients with IgA glomerulonephritis.

Fourty-four patients with IgA-glomerulonephritis (IgA GN) were studied for circulating immune complexes (IC) repeatedly in the course of disease on the evidence of four different methods suited for the detection of IC, viz. complement consumption assay, Clq-solubility test and two tests based on PEG-precipitation, and of indirect signs pointing to the presence of IC. Joint assessment of the direct and indirect signs (positivity of a minimum of 2 indirect signs or any of the direct signs) permitted to ascertain the presence of circulating IC in 72 per cent of the patients and in 63.3 per cent of the examined sera. There was no close relationship between the presence of IC and the clinical activity. On the other hand, in 16 patients positive for the rheumatoid factor (RF) the renal biopsy material revealed extensive vascular lesions. The findings suggest that the circulating IC, some of which contain RF, play a part in the pathomechanism of IgA GN and are involved in the production of the vascular abnormalities in this disease.

Adolescent↗
PubMed1982

Iron turnover in patients with chronic uraemia treated with hemodialysis.

Radio-iron kinetic tests were performed in 7 patients with end-stage renal disease treated by hemodialysis; the study could be completed in 6 patients. The incorporation of radio-iron into the erythrocytes was 21% on average in patients with acute anemia. The red cell life-span determined in 4 patients became significantly shorter in 3 patients. Iron turnover in the bone marrow was significantly lower than normal, the rate of ineffective erythropoiesis being higher. Serum ferritin levels were significantly higher, and tissue and extravascular iron turnover was found to be enhanced compared to normal. At the same time, serum iron level was normal. The data on iron turnover indicated deficient hemopoiesis in the bone marrow, due partly to the lack of erythropoietin and partly to the insufficiency of the BFU-E (burst forming units) and CFU-E (colony-forming units) reserves. Undoubtedly, this was a consequence of the uremia.

Bone Marrow↗
PubMed1982

Clinical features and course of IgA glomerulonephritis.

A review of the clinical features, laboratory findings and course in 50 cases of IgA glomerulonephritis confirmed by biopsy is presented. The onset and clinical course of the process was oligosymptomatic in the majority of the cases with a predominance of microhematuria and persistent proteinuria. By the end of the observation period more than 50 per cent of the patients became hypertensive and in 16 cases serum creatinine levels attained 132 mumol/l (1.5 mg per 100 ml) or more. Proteinuria in excess of 1 g/24h, hypertension and an impaired concentration capacity at the onset heralded early progression.

Adolescent↗
PubMed1981

[Hairy cell leukemia: pathomorphology, cytology and cytochemistry].

In 10 cases of hairy cell leukaemia histological, cytological, cytochemical and in some of the cases immunocytological investigations were carried out. In addition to clinical, cytological and cytochemical findings arising suspicion of hairy cell leukaemia, in three cases the multifocal reaction of acid-phosphatase appeared to be tartarate sensitive (at the concentration of L+-tartaric acid--0,75%), indicating in accordance with findings of Burns et al. (9), that tartarate resistency of the acid-phosphatase reaction ("isoenzyme 5" Katayama és mtsai, 24) has no absolute diagnostic significance. Pathomorphological investigation of different tissues (spleen, lymph node, bone marrow, liver) has revealed the characteristic localization of the spleen infiltrates (cords of Billroth) and the formation of the so called pseudosinuses. These morphological findings may contribute to the diagnosis of hairy cell leukaemia.

Aged↗