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Biomedical subjects

T Brunner

Publications and source records attributed to T Brunner.

At least 73 records · Page 4Linked to original sources
PubMed1978

[The removable partial prosthesis--review of the literature].

Early and late checkups on partial dentures demonstrate clearly, that insufficient cleaning of the remaining dentition and of the prostheses along with an unsatisfactory design are one of the main causes of failures in partial denture therapy. They invariably lead to tissue damages. Hence it has become one of the paramount goals to educate and motivate the patient for adequate mouth and denture hygiene. Also, proper occlusion and the avoidance of parafunction upon the remaining teeth and their supporting tissues must be observed strictly. Therefore, it is important to prepare the remaining dentition carefully and to organize the patients to be recalled for checkups at given intervals. In modern literature on the subject the psychological aspects of difficulties in denture adaptation are more frequently discussed.

Dental Caries↗
PubMed1974

Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.

Mouse cytotoxic T lymphocytes (CTL) were generated in mixed leukocyte cultures (MLC) using spleen cells as responding cells and irradiated allogeneic spleen cells as stimulating cells. Cytotoxicity was assessed by a quantitative (51)Cr assay system and the relative frequency of CTL in individual cell populations was estimated from dose-response curves. Inclusion of 2-mercaptoethanol in the MLC medium resulted in a 20-40-fold increase in the relative number of CTL generated at the peak of the response. Under these culture conditions, cell-mediated cytotoxic activity was detectable in MLC populations as early as 48 h after the onset of the cultures. When spleen cells from mice immunized with allogeneic tumor cells 2-4 mo previously were cultured with irradiated spleen cells of the same alloantigenic specificity (MLC-Imm), it was found that the cell-mediated cytotoxic response was detectable earlier and reached higher levels than that observed in a primary MLC. At the peak of the response, MLC-Imm populations were observed to lyse up to 50% of the target cells within 3 h at a lymphocyte: target cell ratio of 0.3:1. Immunological and physical characterization of the effector cells generated in MLC-Imm indicated that they were medium to large-sized T lymphocytes. Altogether, these studies suggested the existence of an anamnestic cell-mediated cytotoxic response in MLC-Imm.

Animals↗