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Biomedical subjects

T Brain

Publications and source records attributed to T Brain.

4 recordsLinked to original sources

Primary rhabdomyosarcoma of the adult liver.

A 53-year-old male Caucasian presented with a massive liver tumor composed entirely of spindle-shaped cells showing light-microscopic and ultrastructural evidence of rhabdomyoblastic differentiation. No epithelial or other sarcomatous elements were included. Detailed postmortem examination failed to reveal evidence of metastatic tumor or an alternative primary site. There have been only four previous cases of primary rhabdomyosarcoma of the adult liver, all occurring in Japanese men.

Carcinoid Tumor

Pyrogens fail to produce fever in the snakes Psammophis phillipsii and Lamprophis fuliginosus.

1. Preferred body temperature of five diurnal, Psammophis philipsii and three nocturnal, Lamprophis fuliginosus, snakes was measured in a thermal gradient chamber by indwelling colonic thermocouples, before and after injection of a variety of pyrogens. 2. The snakes achieved their preferred body temperature by moving up and down in the gradient chamber; it was about 33 degrees C for P. phillipsii and 25 degrees C for L. fuliginosus. 3. The snakes did not develop fever in response to any of the pyrogens, whether gram-negative or gram-positive in origin, either on the day of injection or on the subsequent day. 4. We believe that fever is rare amongst reptiles.

Animals

Parenchymal brain lesions in spontaneously hypertensive stroke-prone rats.

The gross and histological features of 189 parenchymal brain lesions in 57 spontaneously hypertensive stroke prone rats are described. There were 127 lesions many of them cystic, showing evidence of old haemorrhage. Of these, 71 also showed recent haemorrhage and there were 26 lesions showing recent haemorrhage only. There were 21 small focal lesions with necrosis and scarring but without any old or recent haemorrhage and 15 other lesions showing focal oedema with microcysts. Undoubted histological evidence of recent ischaemic necrosis was not seen. In this animal model which spontaneously develops severe hypertension, the brain lesions are predominantly the result of leakage of blood components from small vessels.

Animals

Project Olympics.

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