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Biomedical subjects

T Bianchi

Publications and source records attributed to T Bianchi.

84 records · Page 5Linked to original sources
PubMedDate not supplied

[Single lung transplantation retrospective analysis of intraoperative cardiovascular problems].

BACKGROUND: Analysis of haemodynamic problems during single-lung transplantation and of methodologies employed for their treatment. METHODS DESIGN OF THE STUDY: clinical retrospective study. SETTING: General University Hospital. PATIENTS: patients with irreversible lung disease, either parenchymal or vascular, undergoing single lung transplantation. INTERVENTIONS: recording of circulatory failure episodes and treatment with pharmacologic support or cardiopulmonary bypass. Modifications occurring during the study period with respect to drugs administered. Evaluation of the consequences of cardiopulmonary bypass on the postoperative outcome, namely on the duration of mechanical ventilation and length of stay in the intensive care unit. RESULTS: During the last 9 years 69 single-lung transplantations have been performed. In 50% of cases a pharmacologic support has been employed; the drug association dobutamine/nitroprusside has been gradually replaced by the association norepinephrine/nitric oxide for the treatment of right ventricular failure. Twenty patients required cardiopulmonary bypass and this caused a significant increase of the duration of mechanical ventilation and length of stay in the intensive care unit. CONCLUSIONS: Hemodynamic changes during lung transplantation are complex and often severe, leading to a clinical status of right ventricular failure, that sometime requires a mechanical circulatory support. The introduction of nitric oxide in clinical practice significantly contributed to the optimization of intraoperative cardiocirculatory profile of patients, leading to a reduction in the use of vasoactive drugs and cardiopulmonary bypass.

Adolescent↗
PubMedDate not supplied

[Malignant mesothelioma of the pleura among women].

BACKGROUND: The epidemiological features of mesothelioma among women differ from those observed among men. OBJECTIVES: To trace the outline of pleural mesothelioma among women in the Monfalcone area, Italy. METHODS: Thirty-three malignant mesotheliomas of the pleura observed in female patients at the Hospital of Monfalcone, Italy, in the period 1979-2002 were reviewed. The diagnosis was based on/or confirmed by necropsy findings in 30 cases. Occupational and social histories were obtained from the patients themselves or from their relatives by personal or telephone interviews. In 29 necropsy cases thoracic cavities were examined for the presence of pleural plaques. Routine lung section were examined for asbestos bodies in 30 cases. In 21 cases asbestos bodies were isolated and counted after chemical digestion of lung tissue. RESULTS: The age of the patients ranged between 48 and 89 years (mean 72.85, median 73.00). All the patients had histories of exposure to asbestos, single in 25 cases and mixed in 8. Exposure at home due to cleaning of work clothes was the most frequent type of exposure. Various patients had been exposed in non-asbestos text industries (cotton mills). Unusual types of exposure occurred in some cases (distillery, small sodium carbonate factory, starch factory). The latency periods (time intervals elapsed between first exposure to asbestos and diagnosis of the tumour), calculated in 23 cases, ranged from 34 to 62 years. Pleural plaques were found in 21 cases. Twelve patients showed asbestos bodies on routine lung sections. The asbestos body burden ranged between only a few bodies and 92,000/g dried tissue. CONCLUSIONS: In contrast with other series of mesothelioma among women, all the present cases were attributable to asbestos. The detection of objective signs of exposure (pleural plaques, lung asbestos bodies) played a key role in attribution.

Age Factors↗
PubMedDate not supplied

Malignant mesothelioma of the pleura among seafarers.

BACKGROUND: A large amount of data indicates that seafarers are at risk for asbestos disease. OBJECTIVES: To trace the outlines of pleural mesothelioma among seafarers. METHODS: Pleural mesotheliomas diagnosed among seamen in the Trieste-Monfalcone area, Italy, in the period 1973-2003, were reviewed. RESULTS: The series comprised 50 men aged between 53 and 91 years (mean age 75.7 years). The diagnosis of mesothelioma was confirmed by necropsy in 38 cases. The patients had served in the Italian Navy (24 persons), in the merchant navy (17 persons), or in both (9 persons). The trades were various including engine room as well as deck personnel. Asbestos bodies were detected on routine lung sections in 55% of the necropsy cases. Asbestos bodies isolated from the lungs in three cases ranged between 2100 and 7000 bodies per gram of dried tissue. Latency periods ranged between 33 and 72 years (mean 56.1 years). CONCLUSIONS: When compared with shipyard workers, the seamen with mesothelioma show signs of less intense exposure to asbestos, and longer latency periods. Mesothelioma in seamen should be considered as an occupational disease.

Age Factors↗
PubMedDate not supplied

[On the incidence of pathogenic staphylococci in feces of persons employed in the foof industry in the 7-year period of 1966-1972 in the province of Milan].

An inquiry on the diffusion of the carriers of faecal pathogen staphylococco between the alimentarist people was performed in the province of Milan during 1966-72. Among 29804 persons examined, 1374 carriers of staphylococci were detected with a frequency of the 4.61 per cent. The strains of isolated staphylococci were with the test of the mannite, coagulase and hemolysins alpha and beta classified as 170 pathogens (12.37 per cent), 511 partially pathogens (37.19 per cent) and 693 non pathogens (50.44 per cent). The strains were sensibles to Rifamycin, Nalidixic Acid, Gentamycin, Kanamycin, and much resistent to the Sulfametoxazin and Ampicyllin.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Sensitivity of staphylococci to mercury and to deoxycholate].

From the pharingeal mucus of many carriers were isolated 155 strains of staphylococci ascribed, by anaerobic fermentation of glucose and mannite, to the groups St. aureus, St. epidermidis and Micrococcus. The sensibility to chloride of mercury and to desoxicholate was tested by inhibition of development on agar of paper stripes impegnated with the solutions of the indicated substances. A specific corresponsion between the sensibility of inhibitory substance and the biological properties of the staphylococci was not observed. However the more pathogen groups were more sensibles to mercury and the non pathogen to desoxicholate.

Deoxycholic Acid↗