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Biomedical subjects

T Berg

Publications and source records attributed to T Berg.

At least 379 records · Page 21Linked to original sources
PubMed1968

The mechanism of oxygen concentration in the swim-bladder of the eel.

1. The P(O2) of venous blood from the active swim-bladder of the eel was shown to decrease with distance from the exit of the rete. This systematic change did not occur in non-secreting bladders, nor during conditions where exchange in the rete had been abolished.2. The observed change in post-rete venous P(O2) has the same rate constant as the Root-on shift.3. These findings modify the accepted model for counter-current multiplication of O(2) in the swim-bladder system by introducing rate constants for diffusion and action of acid in the rete.4. The part played by the assumed impermeability to acid of the arteriovenous partition of the rete is in the modified model replaced by the slow Root-on shift.5. The modified model contradicts the Kuhn model in that extraction of O(2) from blood is decreased at low flow and that at normal flow conditions part of the lactic acid produced can be re-used.6. Similar modifications are indicated in the model for concentration of inert gases.

Air Sacs↗
PubMedDate not supplied

Percutaneous transjugular direct porto-caval shunt in patients with Budd-Chiari syndrome.

The purpose of the study was to evaluate the feasibility and effectiveness of direct porto-caval shunts in patients with Budd-Chiari syndrome (BCS) in whom there is no access to the hepatic veins during transjugular intrahepatic portosystemic shunt (TIPSS). We included six consecutive patients with fulminant/acute Budd-Chiari syndrome (mean age: 35 years) in whom a conventional TIPSS was not possible due to inaccessible hepatic veins. We performed a direct porto-caval shunt via a transhepatic approach. Patients were followed up by means of clinical examination, laboratory investigations, and Doppler ultrasound. TIPSS implantation from the inferior vena cava (IVC) was successful in all six patients (100%). The median transhepatic shunt length was 9 cm (8-10 cm). No procedure-related complications were observed in our patients. Early shunt occlusion occurred in three out of six patients (50%). In all three of these patients, the stent used to stabilize the shunt ended 1-2 cm before reaching the IVC. All occlusions were successfully recanalized. One of these patients developed recurrent early shunt as well as mesenteric and splenic vein occlusions. She died 7 days after TIPSS placement due to an unmanageable coagulation disorder. The remaining five patients were followed up by planned clinical examination and laboratory investigations (mean follow-up time was 15 months; patient 1 was followed up for 13 months, patient 2 for 14 months, patient 3 for 15 months, and patients 4 and 5 for 16 months) and all displayed a complete and durable resolution of liver failure and ascites without reintervention. In patients with acute liver failure originating from BCS and inaccessible hepatic veins, a direct transhepatic porto-caval shunt can be performed safely and effectively under ultrasound guidance. Future studies in larger patient groups should investigate if the patency of transcaval TIPSS with long transhepatic shunt segments is similar compared to conventional TIPSS via the hepatic vein.

Adult↗
PubMedDate not supplied

Molecular heterogeneity for bovine alpha-mannosidosis: PCR based assays for detection of breed-specific mutations.

DNA tests, based on the polymerase chain reaction (PCR), were developed for the detection of two breed-specific mutations responsible for the autosomal recessive disorder bovine alpha-mannosidosis. The tests involve separate amplification of two exons of the lysosomal alpha-mannosidase gene followed by restriction enzyme digestion of the amplicons. We demonstrate that one of the mutations, the 662G-->A transition, is responsible for alpha-mannosidosis in Galloway cattle. The other mutation, the 961T-->C transition, is uniquely associated with alpha-mannosidosis in Angus, Murray Grey and Brangus cattle from Australia. The 961T-->C mutation was also detected in Red Angus cattle exported from Canada to Australia as embryos. All 39 animals classified as heterozygotes on the basis of biochemical assays were heterozygous for one of the two mutations. None of 102 animals classified as homozygous-normal on the basis of biochemical assays possessed the mutations. Our results indicate that the two breed-specific mutations may have arisen in Scotland and by the export of animals and germplasm disseminated to America, New Zealand and Australia.

Animals↗