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Biomedical subjects

T Beppu

Publications and source records attributed to T Beppu.

At least 397 records · Page 22Linked to original sources
PubMed1975

[Melanoma of the spinal cord in pregnancy (author's transl)].

A case of spinal cord melanoma at the level of C2 was reported. A 27-year-old house-wife, in the 8th month of an uncomplicated pregnancy, complained of motor weakness and sensory impairment in the left arm. Then, left lower limb and right upper and lower limbs were gradually involved and she suffered from tetraplegia when she was first admitted to our hospital about two months after the beginning of her symptoms. Neurological and roentogenological examination revealed an upper cervical intradural extramedullary tumor, and laminectomy from C1 to C4 was performed. The tumor was totally removed and diagnosed as a melanocytic melanoma histopathologically. Postoperatively, she had complete recovery. In order to exclude the possibility of a metastatic melanoma, the patient was seen in repeated consultations by dermatology, gastro-enterology, otorhinolaryngology, urology and gynecology services. But, there was no evidence of pigmented lesions anywhere, so we considered this case as a primary melanoma of the spinal cord clinically. Finally, a brief discussion about correlation between the melanoma and the pregnancy was added.

Adult↗
PubMed1972

Specific inhibition of cell division by colicin E 2 without degradation of deoxyribonucleic acid in a new colicin sensitivity mutant of Escherichia coli.

A new class of colicin sensitivity mutants of Escherichia coli was isolated whose cell division was specifically inhibited by colicin E(2) without detectable degradation of deoxyribonucleic acid (DNA) at 30 C. The mutant could not form colonies in the presence of colicin E(2) but recovered colony-forming ability by trypsin treatment even after prolonged incubation with the colicin. Addition of colicin E(2) to the exponentially growing mutant inhibited cell division completely but did not induce degradation of DNA into cold acid-soluble materials nor any breakage of DNA strands. Synthesis of DNA in the mutant was not inhibited, and long filamentous cells with multiple nuclear bodies were formed by the action of colicin E(2). Degradation of ribosomal ribonucleic acid and development of prophage lambda, both of which were induced by colicin E(2) in the sensitive cells, did not occur in the mutant. At the elevated temperature, however, the mutant was found to undergo colicin-induced degradation of DNA. No differences in ultraviolet light nor drug sensitivities were observed in the mutant compared to the parent E. coli. The data suggested that colicin E(2) had a specific inhibitory effect on cell division of E. coli that was not a consequence of DNA degradation.

Bacteriological Techniques↗