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T Beckett

Publications and source records attributed to T Beckett.

11 recordsLinked to original sources

Physical activity and the progressive change in body composition with aging: current evidence and research issues.

PURPOSE: The purpose was to review studies that have examined the effect of aerobic (AEX) or resistance exercise (REX) on body composition in older individuals (>55 yr). Our goal was to examine the effect of these two exercise paradigms on fat mass and fat-free mass and to consider those factors that may explain variability in findings among studies. METHODS: We conducted a literature search (Medline, 1984-1999) for intervention studies (at least 2 months in duration) that have examined the independent effect of either REX or AEX on body composition in older individuals. RESULTS: AEX decreased fat mass (range: -0.4 to -3.2 kg) but had little effect on fat-free mass. The change in fat mass with AEX was related to the duration of the exercise program (r = 0.51; P < 0.02) but not to body composition methodology. In contrast, REX reduced fat mass (range: -0.9 to -2.7 kg) and increased fat-free mass (range: 1.1 to 2.1 kg). Changes in body composition with REX were not related to body composition methodology or the duration of the exercise program. CONCLUSION: Both AEX and REX appear to be beneficial in reducing body fat. REX appears to have the additional benefit of increasing fat-free mass.

Aging↗

Nurturing our own.

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Burnout, Professional↗

Change happens!

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Delivery of Health Care↗

Risky business.

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Disclosure↗

Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes.

We report the sublocalization of the breakpoint in chromosome 22 in 33 patients with chronic myeloid leukemia (CML) who also had unusual marrow cytogenetics. In 23 patients, the leukemic clones were characterized by Philadelphia (Ph1) chromosomes that arose through complex translocations that involved three or more chromosomes. In the remaining ten patients, there were no detectable Ph1 chromosomes despite molecular evidence for the presence of rearrangements in the major breakpoint cluster region (bcr) of chromosome 22 in all cases. There was no significant difference between the two groups with respect to location of the breakpoints within the bcr. When these two groups of patients were combined, there was a significant excess of breakpoints in one segment of the bcr when compared to the distribution of breakpoints seen in 119 patients with simple 9;22 translocations. The difference in breakpoint distributions did not appear to be entirely attributable to differences between groups in disease duration at the time of study. These data support the notion that the unusual genetic recombinations that give rise to BCR/ABL fusion genes in CML involve specific DNA sequences of BCR (and possibly ABL) and additional, recombinogenic sequences, at least some of which are present in loci known to be nonrandomly involved in complex Ph1 translocations.

Adult↗