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T Beck

Publications and source records attributed to T Beck.

157 records · Page 9Linked to original sources
PubMed1975

[Teaching content of medical outpatient instruction in a large municipal hospital (author's transl)].

In a hospital for internal diseases which has been in existence for 10 years and has 150 beds, a course of lectures on "Medical Outpatients" has been given for 17 semesters. At least 3 patients were presented a double period. The emphasis of "simple diagnoses" lay - according to the nature of the clinical aspects - on diseases of the blood, followed by diseases of the digestive organs, the heart and the respiratory tract. The "multiple diagnoses" concerned diseases which were either in relation to each other - diseases of the digestive organs were the most frequent primary diseases here, followed by diseases of the heart and vascular system, the kidneys and the efferent urinary tracts - or diseases which were not in relation at all - here again, the most common were diseases of the digestive organs, followed by metabolic and infectious diseases. Therapeutic aspects (including side effects) occupied a large space. The large municipal hospital offers the best conditions for lectures on outpatient topics related to practice.

Cardiovascular Diseases↗
PubMedDate not supplied

Effects of emopamil on postischemic blood flow and neuronal damage in rat brain.

The effects of the calcium entry blocker emopamil on physiological variables, local cerebral blood flow (LCBF) and on hippocampal cell damage were evaluated after 10 min of forebrain ischemia in the rat. LCBF was determined with the 14C-iodoantipyrine technique after 2, 10, and 60 min of postischemic recirculation. Histological evaluation was performed 7 days after ischemia in cortical and hippocampal tissue by determination of the percentage of necrotic neurons. Preischemic application of emopamil [4 mg/kg racemate or 2 mg/kg (S)-emopamil; i.v.] caused increased in LCBF in cortical areas but did not alter blood flow in the hippocampus at 2 min of recirculation. After 10 and 30 min of flow resumption no differences in LCBF between drug-treated and control animals were observed. In the histological series (S)-emopamil was applied at doses of 2, 4 or 6 mg/kg before the induction of ischemia. After 7 days of postischemic recovery, neuronal damage was significantly reduced by the calcium antagonist in hippocampal CA1 sector at all doses tested, the most prominent effects being observed with the lowest dose. At this dose cell loss in the CA3 sector was also reduced. In cortical tissue the number of necrotic cells remained unchanged by emopamil treatment. It is concluded that the calcium antagonist emopamil can reduce ischemia-induced neuronal cell damage. The compound improves circulation in cortical tissue only during early recovery but not at later phases of reflow, i.e. the period of delayed hypoperfusion. These increases in blood flow are not of crucial importance for ultimate neuronal death in this area.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

[Axial load in case of press-fit fixation of the ACL graft--a fundamental study].

AIM: The aim of this study was the determination of the axial fixation load resting on smooth press-fit dowels needed for fixation of the patellar tendon graft (BTB) in order to reach the same fixation properties compared to the interference screw on anterior cruciate ligament (ACL) plasty. METHOD: Bovine test specimens with 27 BTB grafts fixed in tibial drill holes were used and divided in 3 groups: interference screw, and press-fit cylinder (Ø 7 mm) with 150 N and 100 N axial loads. Prior to fixation, impactation of the transplant into bone was carried out. Failure testing was done in a tensiometer at a cross-head speed of 50 mm/min. Determinations of peak load and stiffness were also made. RESULTS: Similar peak loads and stiffness were reached on introducing a press-fit dowel (slashed circle 7 mm) with 100 N and 150 N axial load compared to interference screw fixation of the BTB graft. Peak load: 988.1 N +/- 365.1 (screw) versus 1 210.4 N +/- 292.4 (dowel 150 N) and 1 109.8 N +/- 505.4 (dowel 100 N). Stiffness: 86.4 N/mm +/- 20.5 (screw) versus 102.4 N/mm +/- 15.2 (dowel 150 N) and 77.1 N/mm +/- 11.0 (dowel 100 N). There was no significant difference. CONCLUSION: When introducing a press-fit dowel (slashed circle 7 mm) with 100 N axial load into a preformed bone bed, the same fixation properties are reached as in the case of an interference screw on BTB-ACL plasty.

Animals↗
PubMedDate not supplied

Preparation of oligodeoxynucleotide 5'-triphosphates using solid support approach.

We report a synthetic procedure for conversion of oligonucleotides to their 5'-triphosphate derivatives with moderate yield. The oligonucleotides were synthesized on solid support using standard phosphoramidite protocols. The DMT protection group was removed and the 5'-OH was phosphitylated using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one followed by reaction with tributyammonium pyrophosphate and iodine oxidation. After subsequent removal from support and complete deprotection, the products were isolated by anion-exchange HPLC chromatography. Structures of several 5'-triphosphate derivatives have been proven by phosphorus NMR, Mass-spectrometry and by HPLC comparison with authentic samples.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

[Maternal and fetal metabolic parameters in acute and chronic fetal malnutrition].

The respiratory pathophysiology of placental insufficiency is well understood, whereas the metabolic effects of chronical or acute malnutrition still need further evaluation. In a comprehensive study of 20 deliveries respiratory parameters and substrates of carbohydrate- and lipid-metabolism were analysed simultaneously from maternal blood at 4 cm dilatation, at cord clamping immediately delivery and 2 hours post partum as well as from arterial and venous umbical blood samples. Normal deliveries were compared with cases of fetal retardation and moderate acute fetal acidosis. For glucose, insulin, c-peptide and pyruvate a strong rise in maternal blood during labour was observed as well as for the non-esterified fatty acids (NEFA), which have a high materno-fetal gradient. Arterio-venous differences of concentrations were found in the umbilical cord blood for glucose, pyruvate and NEFA. In cases of chronical insufficiency of the placenta especially elevated lactate levels were measured, whereas a moderate fetal acidosis obviously leads to an additional feto-maternal pyruvate transfer. The results lead to the conclusion that the fetal metabolism has considerable means of adaptation during delivery even under chronical or moderate acute stress conditions.

Blood Glucose↗
PubMedDate not supplied

[Degree of placental maturity and histopathologic finding: clinical prospective studies of a sample of term births and premature births].

By analogy with Grannum et al.'s sonographic classification of the placenta (1979), macroscopic observation of the cut surfaces of the afterbirth enables the extent of placental segmentation to be determined and macroscopic maturity to be established in accordance with sonographic findings. Out of a total of 767 clinically-prospectively documented obstetrical cases, 674 were identified as term births and 93 as premature. For the purposes of comparison they were subdivided into two groups: term births with stage 0 to II and stage III maturity; and premature births with stage 0 to II and stage III maturity. Proceeding from this morphological classification and grouping, the clinical data, such as age of the mother, parity, gravidity, diseases during pregnancy, premature labour, type of delivery, fetal outcome, and biometric data of the newborn, as well as histologic findings regarding villous maturity, were recorded and statistically analyzed. The findings revealed no significant differences between term births with stage III maturity and those in the control group of placentas with stage 0 to II maturity and the same gestation time. Therefore, stage III maturity at term corresponds chronopathologically to a normal temporal development of fetomaternal flow units of the mature human placenta at term and does not imply any perinatological risk. Histopathologically, placentas with stage III maturity manifest a significantly advanced degree of villous maturity, with lower mean placental weight as the morphological correlate to threshold placental function, which is reflected in the clinical data of perinatological complications. Therefore, premature detection of a stage III placenta before term indicates a risk that should be kept in mind in the overall concept of prenatal monitoring parameters.

Chorionic Villi↗
PubMedDate not supplied

[Venous outflow from the intervillous microcirculation in the human placenta].

This paper presents a morphological description of the venous area of the maternal circulation in the mature placenta. By injection of contrast medium into adjoining fetal cotyledons in 24 placentas the common intercotyledonal venous blood outflow pathways were specifically demonstrated, both radiologically and histologically. The interweaving and density of the terminal villi, the number and location of nuclear bridge formations, the width and course of the intervillous spaces, and the form of the columns and vela are characteristic of the venous outflow areas. The calcium incrustations found in varying degrees are likewise closely associated with venous area of the intervillous microcirculation. The findings are interpreted with regard to their importance for understanding the maternal placental blood flow in relation to the flow unit of the so called placenton.

Calcium↗
PubMedDate not supplied

[Maternal blood flow in the human placenta (author's transl)].

The intervillous microcirculation in the human placenta is still a subject of debate. This paper aims to establish whether or not a division of the human placenta into flow units - the "placentons" of Schuhmann et al. (1971, 1976) - is morphologically conceivable, and what pathways exist for the maternal blood flow through the intervillous space. The findings are compared with flow models published in the literature, and are discussed. Spiral arterial punctures were performed in 22 fresh placentas from term births using Wigglesworth's procedure, and the intervillous space was filled with Microfil. In five other placentas the fetal villi were also contrasted with Micropaque and gelatine. Six control placentas, which were not filled with contrast medium, served to eliminate the possibility of filling artefacts. Plain radiographs in choriobasal projection, lateral films of the lamillarly dissected injection regions and histologic serial sections documented the pathways followed by the contrast medium. The human placenta can be divided into flow units: each fetal cotyledon can be shown to be supplied by a maternal spiral artery. Within the flow units, flow is routed through arterial, capillary and venous areas can be clearly identified. They were also demonstrated in the control placentas, which were not filled with contrast medium.

Chorionic Villi↗
PubMedDate not supplied

[Histology of chorioamnionitis: relations to maternal and fetal infection parameters].

With regard to clinical diagnosis and prognosis, intrauterine infection continues to pose major problems for obstetricians. In recent years serum assay of CRP, an acute phase protein, has become firmly established in the obstetric management of premature rupture. We investigated the relationship between histologically confirmed chorioamnionitis and maternal and fetal inflammation parameters in 69 patients on the basis of inflammation of the membranes, placenta and cord occurring in histomorphologic stages. Our results show the C-reactive protein to be a sensitive and specific indicator of chorioamnionitis and closely correlated with both the histologic stage and the severity of the chorioamnionitis. We therefore advocate adoption of the histologic result as the "gold standard" for evaluating subclinical and clinically manifest forms of intrauterine infection.

Adult↗