Search PubMed⌕ Search

Biomedical subjects

T Bardin

Publications and source records attributed to T Bardin.

At least 127 records · Page 7Linked to original sources
PubMed1985

Reiter's syndrome in Greenland. A clinical and epidermiological study of two communities.

Patients with post-venereal Reiter's syndrome, living in the districts of Egedesminde and Jakobshavn in Greenland, were ascertained from medical records and patient examinations. Fifty-one patients were found to have definite Reiter's syndrome according to the ARA proposed criteria. The prevalence of the disease is 1.08% in Egedesminde and 0.34% in Jakobshavn. Annual incidences and prevalences show a marked increase between 1960 and 1983. Retrospective follow-up data on all patients show that the disease recurs in over 85% of cases for which the follow-up period is 10 years or longer.

Adolescent↗
PubMed1984

[Articular inflammation of microcrystalline origin].

Microcrystals of sodium urate, calcium pyrophosphate, hydroxyapatite and corticosteroids may induce acute arthritis by similar mechanisms in which neutrophils play the most important role. Interactions between neutrophils and microcrystals result in the release of several phlogogenic substances, e.g. lysosomal enzymes, chemotactic factor (CCF) or leukotrienes. Various proteins may be adsorbed to the surface of microcrystals, and this protein coating seems to be instrumental in modulating the neutrophil-microcrystal interaction. The Hageman factor and the complement system may also be activated. The mechanisms starting off and resolving articular attacks are discussed.

Acute Disease↗
PubMed1984

Destructive spondylarthropathy in hemodialyzed patients. A new syndrome.

Spinal radiologic lesions suggestive of destructive spondylarthropathy were found in 10 patients on long-term hemodialysis. These lesions were characterized by severe narrowing of the intervertebral disc, associated with erosions and geodes of the adjacent vertebral plates without osteophytosis. In 9 of the 10 patients the lesions were located in the cervical spine, and in 1 patient, in the lumbar spine. Microbial spondylitis, degenerative disc disease, and destructive spondylarthropathy of calcium pyrophosphate dihydrate deposition disease were each, in turn, ruled out. The finding of apatite crystals by transmission electron microscopy in 1 disc specimen suggests that these crystals may be associated with destructive vertebral disc lesions in dialysis patients.

Aged↗
PubMed1984

Transmission electron microscopic identification of silicon-containing particles in synovial fluid: potential confusion with calcium pyrophosphate dihydrate and apatite crystals.

Silicon-containing particles were identified by transmission electron microscopy (TEM) in thin sections of two synovial fluids, which also contained calcium pyrophosphate dihydrate (CPPD) crystals, aspirated during acute attacks of pseudogout. Such particles, which are interpreted as probably being artefacts from glassware, were electron dense and similar in appearance to some CPPD or hydroxyapatite crystals.

Aged↗
PubMed1984

HLA-DR genotype risks in seropositive rheumatoid arthritis.

We studied the distribution of HLA-A, B, C, and -DR antigens in 77 Caucasian patients with sero-positive rheumatoid arthritis. Forty-four patients were genotyped and compared with the control panel of 110 unrelated Caucasian genotyped donors. The data obtained confirm the association of DR4 with RA, and reveal an increased risk of disease for patients carrying DR1, DR2, and DR3, compared to the risk for those carrying other antigens, such as DR5, DRw6, and DR7. There is a higher risk for DR4/4 homozygotes than for DR4/1, DR4/2, or DR4/3 heterozygotes. DR4/5, DR4/6, and DR4/7 have a lower risk than the previously mentioned genotypes. The genotype risks are compatible with the inheritance of a single, linked genetic determinant of disease susceptibility, but we are unable to distinguish between recessive and dominant inheritance of susceptibility using the "antigen-frequencies-amongst-diseases" method. DR4 seems to be more frequent in patients in whom onset occurs before the age of 35 (79% vs. 54% DR4 positive). A significant excess of DR3 + is observed in patients with toxic complications following treatment with gold salts (X2(1) = 8.96).

Adult↗
PubMed1984

Tumoral calcinosis: light and electron microscopic study with electron diffraction and x-ray microanalysis of the mineral deposit.

Samples of deposits taken from sites close to articulations in a young black African suffering from tumoral calcinosis with hyperphosphoraemia were studied by light and electron microscopy techniques. Light microscopy demonstrated lesions of a foreign body granuloma type in contact with calcium salt deposits suggesting that the process was of an active nature. Electron microscopy, and the demonstration of acid phosphatase activity, led to the identification of two cell types: mono or multinuclear macrophage type cells which phagocytose the deposit, and fibroblastic type cells. No signs of damage to the microvessels or the interstitial collagen were noted which could serve as a basis or a physiopathological explanation of the deposition. The deposits were analysed by energy dispersive X-ray microanalysis and by electron diffraction and were considered to be hydroxyapatite.

Acid Phosphatase↗
PubMed1984

A study of microvasculature in normal and inflammatory synovial membranes in the rabbit using light and electron microscopy and freeze fracture.

The Authors made a study of microvasculature in normal and inflammatory synovial membranes in the rabbit, by light and electron microscopy and with the use of freeze fracture. The synovial membrane of the knee was studied in 15 normal rabbits and in 22 rabbits in whom immunization with mycobacterium tuberculosis crude cytoplasmic water soluble extract had provoked inflammatory synovitis. A comparison between normal and inflammatory synovia by light microscopy showed, in inflammatory synovitis, a significant increase in the number of congested and obliterated microvessels (p less than 0.001) and in the number of endothelial nuclei per microvessel (p less than 0.0001). By electron microscopy no specific alteration of synovial microvessels was observed. A significant increase was found in the number of venules in inflammatory synovitis (p less than 0.01). The number of simple interendothelial tight junctions, defined by 1 or 2 interendothelial contacts, and of complex interendothelial tight junctions, defined by 3 or more interendothelial contacts, was similar in venules and in capillaries of inflammatory synovitis and of normal controls. The mean number and mean spacing of junctional strands in interendothelial tight junctions was similar in the microvessels of inflammatory synovitis and of normal controls. The Authors conclude that inflammation does not provoke specific alterations in synovial microvasculature but could induce an adaptative state resulting in increased synovial permeability.

Animals↗
PubMed1984

Immunoglobulins on the surface of monosodium urate crystals: an immunoelectron microscopic study.

The ability of monosodium urate (MSU) crystals to bind immunoglobulins from human serum was investigated by immunoelectron microscopy. Synthetic MSU crystals were incubated with serum and then processed with an indirect immunoperoxidase technique which used primary antibodies directed against human IgG, IgA or IgM, respectively specific for Fc fragments, alpha chains, and mu chains. Results were analyzed by transmission electron microscopy on intact crystals dried on formvar coated grids, and in thin sections. Both techniques demonstrated the binding of IgG, IgA and IgM to MSU crystals and the availability of the Fc fragment of the crystal bound IgG for immunologic reactions.

Crystallization↗
PubMed1983

[Hemopigmented villonodular synovitis: ultrastructural study and a comparison with hemophiliac synovitis].

In a study of the ultrastructure of two cases of villonodular synovitis and two cases of haemophiliac synovitis, the authors observed very similar lesions. In both diseases, the lesions of the superficial layer of the synovium consisted of intermediate type (type C) synoviocytes loaded with iron pigments or lipid vacuoles. In the deep layer, the authors observed numerous macrophages loaded with siderosomes, lipid inclusions or phagocytosed red blood cells, giant cells and capillaries with a thickened basement membrane with a layered appearance. The cytoplasmic membranes of the synoviocytes were joined by desmosomes or filopodal digitations. The similarity of the lesions in the two diseases suggests a common histogenetic mechanism for the synovial lesions: chronic haemarthrosis.

Cytoplasm↗
PubMed1982

[Rheumatoid arthritis and HLA system. A search for correlations between histocompatibility antigens and characteristic features of the disease].

Possible correlations between the HLA antigens A, B, C and DR and the clinical and biological features of rheumatoid arthritis were investigated in 74 patients with positive serology. The DR 4 antigen was present in 46 of these patients (62%), being apparently more frequent in those whose disease had begun before the age of 35 (p less than 0.05). DR 4 was also more common in pure rheumatoid arthritis than in forms associated with Gougerot-Sjogren's syndrome (p less than 0.05). No correlation could be found between the HLA phenotype and the other parameters studied, i.e. sex, corticosteroid therapy. Steinbrocker's radiological stages, plasma levels of rheumatoid factor and gammaglobulins and presence of antinuclear antibodies.

Adult↗
PubMed1982

[Rheumatoid arthritis with antinuclear factor. A prospective study of 50 cases (author's transl)].

The clinical and laboratory features of rheumatoid arthritis (RA) with antinuclear factor (ANF) were prospectively analyzed in 50 patients and compared with those of another series of 50 patients of similar age, sex and duration of disease, but without ANF. The severity of articular lesions was about the same in both series, but systemic symptoms and Gougerot-Sjögren syndrome occurred more frequently in patients with ANF. Gold compounds and D-penicillamine appeared to be well tolerated by all patients. RA patients with ANF had more strongly positive responses to latex and Waaler-Rose tests. Farr's radioimmunoassay was sometimes positive (11/49), but as a rule, the degree of positivity was inferior to 50%.

Adult↗
PubMed1982

HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.

Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype.

Adult↗
PubMed1981

[Synovial vascularization and inflammation. II. Electron microscopy study of capillary permeability using immunoperoxidase].

The distribution of IgG and IgM into the normal and rheumatoid synovial membrane have been studied by the authors by means of immunoperoxidase electron-microscopy. Within the normal synovial while the IgG are diffusing out of the capillary the IgG are kept in the vascular lumen. Within the rheumatoid synovia IgG and IgM widely diffuse out of the microvasculature. This finding suggest that the rheumatoid inflammation is raising the permeability of synovial capillaries towards IgM molecules.

Arthritis, Rheumatoid↗