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Biomedical subjects

T Bani Sacchi

Publications and source records attributed to T Bani Sacchi.

At least 37 records · Page 2Linked to original sources
PubMed1985

Nesidioblastosis and intermediate cells in the pancreas of patients with hyperinsulinemic hypoglycemia.

The pancreases of three patients with hyperinsulinemic hypoglycemia were studied: one of these patients was a child born to a diabetic mother, the other two were adults with insulinomas. All the patients had nesidioblastosis, namely the presence of a number of pancreatic endocrine cells spread throughout the exocrine tissue singly or clustered in small groups. In the hypoglycemic child the endocrine cells scattered in the acinar tissue were mostly A cells, whereas in the patients with insulinomas both A and B cells were found with a similar frequency. Intermediate cells (acinar-islet cells) were found in all the cases. These findings suggest that nesidioblastosis and the de novo formation of intermediate cells are associated phenomena. Possible mechanisms for the genesis of the islet cell types spread throughout the exocrine parenchyma and of the intermediate cells are discussed and their possible clinical implications are suggested.

Adenoma, Islet Cell↗
PubMed1985

Nesidioblastosis and islet cell changes related to endogenous hypergastrinemia.

The endocrine pancreas from four hypergastrinemic patients with recurrent peptic ulceration has been studied by light and electron microscopy. Greatly increased numbers of ducts and centroacinar cells have been observed associated with a striking increase in the number of islets and endocrine cells scattered in the acinar tissue (nesidioblastosis). The islet cells scattered throughout the exocrine parenchyma are of all the known islet cell types, with a prevalence of B and especially A cells. Many islets, probably formed de novo, are of a considerable size, have irregular contours and are in close apposition to centroacinar cells and ducts. The degree of nesidioblastosis and islet hyperplasia does not seem to be related to the plasma gastrin levels. Cytological changes have also been found in the islet cells of the hypergastrinemic patients compared with controls. These changes mainly affect the B cells and consist of a striking decrease in the number of mature secretory granules associated with a fairly extended ergastoplasm and Golgi apparatus and with a relevant increase in the number of immature granules. In two of the four patients examined, who had more severe hypergastrinemia, cytological signs of enhanced secretion are also recognized in A cells. The features indicating hypersecretion of B and A cells seem to be related to the plasma gastrin levels. The above findings indicate that chronic endogenous hypergastrinemia promotes proliferation and differentiation of islet cells and stimulates the secretory function of B cells and, to a lesser extent, of A cells, thus providing evidence for a trophic and secretagogue action of gastrin on the endocrine pancreas.

Female↗
PubMed1985

New views on the identification of the various cell types in the pancreatic islets of the rat. An ultrastructural and morphometrical study.

Islets of Langerhans taken from different parts of the pancreas have been studied ultrastructurally in adult rats. Five different islet cell types were identified in each islet with the aid of morphometrical analysis of their specific secretory granules. Previous immunohistochemical findings concerning the amount and location of insulin-, glucagon-, somatostatin- and pancreatic-polypeptide-containing cells and their ultrastructurally recognizable counterparts were compared, and it was possible to identify four main islet cell types with the electron microscope. Moreover, cells quite similar to the enterochromaffine cells described elsewhere in the exocrine pancreas and in the gastrointestinal tract were found to normally occur in the pancreatic islets of the rat.

Animals↗
PubMed1983

The effects of chronic hypergastrinemia on human pancreas.

The pancreas of four patients with chronic hypergastrinemia and recurrent peptic ulcer--without pancreatic tumors--were studied by light and electron microscopy. Centroacinar and ductular cells were increased in number, enlarged and richer in organelles, microfilaments and apical microvilli compared to the controls. The hyperplasia of these cells was significantly correlated with the peak values of gastrinemia stimulated either by secretin or by calcium. Zymogenic cells were degranulated to various degrees and always had well-developed ergastoplasm and Golgi apparatus. The degree of degranulation was significantly correlated with the peak values of stimulated gastrinemia. Cells with features intermediate between ductular and islet cells were found near some islets and typical islet cells (mostly A and B cells) were observed in the walls of some ductules and acini. These results suggest enhanced secretion of both bicarbonate and enzymes and neogenesis of islet cells from ductular cells during chronic hypergastrinemia.

Cytoplasmic Granules↗