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Biomedical subjects

T Banciu

Publications and source records attributed to T Banciu.

At least 19 recordsLinked to original sources
PubMed1988

Antibody dependent cytotoxicity in chronic active liver disease.

Twenty-six patients with chronic active liver disease (CALD) and a control group (8 patients with atrophic gastritis and 10 healthy people) underwent a microcytotoxicity (MCT) test using a primary line of human hepatocytes (5 1/2 month old human embryo) in the presence of rabbit complement. In 57.6% of the cases with CALD the test was positive (over 60% of hepatocytes lysed on contact with the patients' serum). The controls showed a negative MCT test, except for one case (12.5%) of atrophic gastritis. The positive results of the test in the CALD patients coincided with the evolutive stage of the disease and with obvious immune, humoral and cellularly, disturbances. The mechanism of the antibody dependent cytotoxicity mechanism in the hepatocytolysis in CALD is being demonstrated; the MCT test may be a marker of the evolution of the disease.

Antibody-Dependent Cell Cytotoxicity↗
PubMedDate not supplied

Prevalence of chronic (latent) pancreatitis in hospitalized chronic consumers of alcohol.

A pancreatic echographic investigation was carried out in 120 chronic consumers of alcohol, hospitalized for digestive diseases (hepatic, gastrointestinal) or extradigestive diseases (rheumatic, cardiovascular). Seventy cases (66%) presented pancreatic echographic--structural changes of various degrees. In 50 patients (41.5%) these changes were well definite. The intensity of echographic changes was correlated with the degree of alcoholic impregnation, 50% of the cases presenting also alcoholic hepatic disease. Emphasis is laid on the clinical latency of pancreatic disease. Echographic screening proved to be a valuable method for the detection of latent pancreatic fibrosis in heavy alcohol consumers.

Alcoholism↗
PubMedDate not supplied

[Early cirrhosis, an early modality of the evolution of acute hepatitis. The clinico-biological, immunological and morphological aspects].

A group of 12 patients with recent acute hepatitis (8/86 with HVB and 4/22 with alcoholic hepatitis) had a rapid evolution (under 2 years) towards hepatic cirrhosis (early H.C.). The clinical-biological, immunological and morphological study made evident several characteristics, which became predictive markers of the early cirrhotic evolution of acute hepatitis. Clinically, a persistence of dyspeptic disorders and appearance of several systemic manifestations is noticed. Biologically, the maintenance of some increased transmainases, variable bilirubinemia and decrease of serinemia. Immunologically, the transfer of IgM towards increased IgM, the decrease of the total T lymphocyte and of T1 substrate, the increase of the active B and T lymphocyte. The morphologic exploration is decisive for specification of the diagnosis in the early hepatic cirrhosis.

Acute Disease↗
PubMedDate not supplied

The diagnostic and therapeutic contribution of calcium channel inhibitors (nifedipine) in esophageal spasm.

The effect of nifedipine (10-20 mg) on esophageal motility was tested in 18 patients with clinical esophageal syndrome and radiologic aspect suggesting esophageal spasm. The drug was administered 20-30 min prior to the second radiologic examination. In 3 cases of achalasia the drug was administered in doses of 10 mg/day for 10 days before the second X-ray examination. Fiber esophagoscopy was performed in all the cases. The initial radiologic aspect was favourably influenced by nifedipine administration in 12 cases confirmed as esophageal spasm. The other 6 patients who did not benefit by the test were cases of organic diseases: 2 post caustic stenoses and 4 cases of eso-cardio-tuberal neoplasm. In the 3 cases of achalasia, treatment with nifedipine led to clinical improvement with relaxation of inferior esophageal contraction on radiologic examination. The study demonstrated the favourable contribution of calcium channel inhibitors to the diagnosis and treatment of esophageal motility disturbances.

Diagnosis, Differential↗