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Biomedical subjects

T Bacia

Publications and source records attributed to T Bacia.

82 records · Page 5Linked to original sources
PubMedDate not supplied

[Relationship between blood serum luminal and diphenylhydantoin level and the results of treatment and other clinical data in drug-resistant epilepsy].

The authors report a statistical analysis of the levels of phenobarbital (PH) and diphenylhydantoin (DPH) in a group of 100 patients with different types of epilepsy mostly resistant to pharmacological treatment. The mean values of PH and DPH were compared with the types of epilepsy, duration of the disease, additional treatment, EEG changes and therapeutic results. The following conclusions have been reached: a) therapeutic ranges of the PH and DPH levels in this group of patients were greater than those reported by others. b) no significant correlation is found between the levels of these drugs and the type of epilepsy, disease duration and EEG changes, with the exception of a positive correlation with PH level. c) Clonazepam, diazepam and mysodin raised the serum PH level in the serum, while only amizepine raised the DPH level. d) higher levels of PH and DPH were found in patients with poor therapeutic results.

Adolescent↗
PubMedDate not supplied

[Surgical treatment of epilepsy: current status and results of own observations].

New diagnostic possibilities make possible a more precise localization of epileptogenetic foci and surgical treatment of epilepsy is associated presently with minimal risk. This was the reason of a surge of interest in recent years even in those countries where this method has not been used. In our country operations for chronic refractory epilepsy have been performed since over 35 years and the gathered experience is sufficient to reach conclusions about the results. The results depend in a certain degree on the location of the focus and the surgical possibility of its removal. In about 50% of the cases cure was effected, and in 15% improvement was achieved near cure. Considering that the treated patients had long-standing and refractory epilepsy with very frequent seizures the results of surgical removal of epileptogenic focus were very good. The authors believe that patients with chronic, focal and refractory epilepsy should be treated surgically, and conservative treatment without considering this possibility is erroneous.

Electroencephalography↗
PubMedDate not supplied

[Incidence of brain tumors in cases of chronic epilepsy treated surgically].

An incidence of tumors of the brain as a cause of drug-resistant epilepsy have been analysed. The analysis included patients operated for epilepsy at the Department of Neurosurgery, Medical Academy in Warsaw between 1987 and 1991. Malignant tumors were found in 21 out 85 patients (24.7%) treated surgically, 22.4% were benign tumors, and 52.9%--lesions of cicatricial character. The most frequent malignant tumor was fibrillary astrocytoma, noted in 57.1% of cases. Neurological examination has revealed discrete symptoms only in 2 out of 21 patients. CT scans have showed non-characteristic focus of decreased density in 12 patients (57.1%). Differentiation of tumor-produced epilepsy and those due to other focal lesions could not be made with the clinical course of seizures and EEG records. Actually, an incidence of tumors of the brain causing seizures refractory to pharmacologic treatment is increasing. Not characteristic clinical course and EEG records as well as CT scans are the main causes of delays in the surgery.

Adolescent↗
PubMedDate not supplied

[Callosotomy in treatment of severe epilepsy].

The authors present palliative therapy of severe epilepsy, i.e. callosotomy. Experimental studies and numerous clinical trials indicate possible use of this technique. However, there are no precise indications and contraindications to the treatment with this technique. The authors discuss own experience with 8 epileptic patients refractory to preservative therapies. These patients were treated surgically with anterior callosotomy. Small number of patients and relatively short period of the follow-up do not allow more general conclusions to be drawn. However, in 3 out of 4 operated patients an improvement was noted within one year or more, including one case of significant improvement. No improvement was seen in one case. The authors will collect other cases. However, it is worth emphasizing that callosotomy is performed in Poland, already.

Corpus Callosum↗
PubMedDate not supplied

[Results of monotherapy in mild and drug-resistant forms of epilepsy].

Monotherapy with one drug chosen out of basic anti-epileptic agents was carried out in 312 patients, including 2/3 of cases resistant to the drugs. Group A consisted of 110 patients treated with a single drug since the onset of the disease whereas group B consisted of 202 patients in whom polytherapy was reduced to monotherapy. The best results were achieved in patients of group A with short and medium duration of the disease. The results noted in patients of group B were worse and independent of the duration of epilepsy. The most favourable effects were noted in children with mild epilepsy and generalized epilepsy of unknown post-traumatic etiology. The results of monotherapy in focal seizures and epilepsy with organic lesions were markedly worse. The most effective drugs in this population were: barbiturates, valproic acid derivatives, and carbamazepine. The authors stress that all forms of epilepsy, especially newly diagnosed and previously untreated cases, should be treated with single agent.

Adolescent↗
PubMedDate not supplied

[Somatosensory potentials evoked in patients with epilepsy recorded from the scalp and from the exposed cortex during surgery].

Somatosensory evoked potentials (SEP) were recorded from the scalp in 47 patients and intraoperatively from the exposed cortex in 30 persons with various forms of focal epilepsy. SEP from stimulation of the median nerve were recorded from the standard derivations: F3, F4, C3, C4, T3, T4, P3, P4 and/or electrodes placed on the exposed cortex. Primary cortical negative (N20) and positive (P20) responses were analyzed. Surface recordings were normal in majority of cases (79%). The most common abnormality was the lack of cortical waves in the damaged area (mostly frontal region) or the absence of cortical responses in the whole hemisphere when central area was involved. Comparing cortical responses obtained before and during operation we found that they were similar (polarization, latency) in the majority of cases there was no response before and intraoperatively. SEP are primarily influenced by organic brain damage symptoms, but not by functional brain changes.

Adolescent↗