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Biomedical subjects

T B Jones

Publications and source records attributed to T B Jones.

50 records · Page 3Linked to original sources
PubMed1980

Sonographic characteristics of congenital uterine abnormalities and associated pregnancy.

Faulty development of the mullerian duct system results in various uterine, vaginal, and renal abnormalities. Complete or partial absence of mullerian duct fusion and/or canalization results in septate, bicornuate, or double uterus; the specific anomaly depends upon the degree of fusion and canalization. Unilateral renal agenesis is frequently associated. Three cases of uterine anomalies associated with pregnancy are presented. When a pregnancy occurs in one side of a double uterus, the nonpregnant side may simulate a solid pelvic mass, such as a leiomyoma. In anomalies where there is a communication between two uterine cavities, the nonpregnant side may require the appearance of a cystic mass. Pregnancy associated with uterine anomalies carries significant morbidity.

Adult↗
PubMed1977

Immunologic tolerance to HGG in mice. I. Suppression of the HGG response in normal mice with spleen cells or a spleen cell lysate from tolerant mice.

Adoptive transfer of spleen cells or spleen cell lysates from mice tolerant to human-gamma-globulin (HGG) specifically suppressed the response of normal syngeneic recipients to HGG. The suppressive activity could be transferred for over 100 days after tolerance induction. The suppression induced by both spleen cells and spleen cell lysate was found to be specific as evidenced by a normal response to a challenge with turkey-gamma-globulin or goat erythrocytes. The activity of the suppressive lysate could be removed by passing the material through an HGG immunoadsorbent column but not by passing it through an anti-HGG column or a BSA column. These results indicated that the factor had antigen specificity and was probably not antigen-antibody complexes. That this suppression was not due to a shifting of the kinetics of the antibody response has also been demonstrated. The antigen-specific suppressor factor in the tolerant spleen cell lysates was a protein with a m.w. of approximately 45,000 daltons. The kinetics of the appearance of both suppressor cells and suppressor factor were consistent with a mechanism of active suppression functioning in the maintenance of tolerance to HGG.

Animals↗
PubMedDate not supplied

Volumetric determination of placental and uterine growth relationships from B-mode ultrasound by serial area-volume determinations.

Serial area-volume determinations may be made from B-mode ultrasonography. Multiple sonographic sections are taken through a structure of interest. The area of the structure of interest is determined on each sonographic section by a form of planimetry and multiplied by the step-interval to obtain the volume of the structure of interest between sonographic sections. The total volume of the structure of interest is the sum of the individual volumes. The volume is computed from both transverse and longitudinal images and an average obtained for improved accuracy. Total intrauterine volume and placental volume were determined by the serial area-volume method in 63 normal patients and the results were analyzed. Placental and total intrauterine volumes were also determined for five cases of intrauterine growth retardation. Although there is some error in the serial area-volume method, the initial evaluation of five cases with intrauterine growth retardation suggests a greater precision and accuracy than volume estimates based on prolate ellipsoid geometry. Placental volume may provide an acceptable parameter to screen for intrauterine growth retardation.

Female↗
PubMedDate not supplied

Effects of intrapartum zidovudine therapy on fetal heart rate parameters in women with human immunodeficiency virus infection.

OBJECTIVE: To determine the effects of intrapartum maternal administration of zidovudine on fetal heart rate (FHR) parameters in women infected with the human immunodeficiency virus (HIV). METHODS: Term HIV-infected women who delivered at our institution (1995-1998) were identified by medical records coding. Sixty minutes of FHR tracing prior to zidovudine administration and 60 min of FHR tracing 2 h after initiation of therapy were reviewed by 3 perinatologists blinded to patient status. Data were compared with paired t tests; p < 0.05 was considered significant. Inter- and intra-observer FHR interpretation variation were calculated. RESULTS: Ten patients met study criteria. Their demographic data included: Maternal age 26.5 +/- 6.5 years, gestational age 38.9 +/- 1.3 weeks, median parity 2 (range 0-3). Eighty percent were African American. There were no significant differences in FHR parameters after intravenous zidovudine therapy (pretreatment versus 2 h after treatment) with respect to FHR baseline (p = 0.2), FHR variability (p = 0.3), or the number of accelerations (p = 0.1). There was also no difference in the number of variable (moderate or severe), early, or prolonged decelerations following zidovudine infusion. CONCLUSION: Two hours of continuous intrapartum intravenous infusion of zidovudine does not alter any parameter of the FHR in the laboring HIV-infected gravida.

Adult↗
PubMedDate not supplied

Abnormal second-trimester ultrasounds: an indication for karyotype.

There are limited data on the risks of aneuploidy for normal-appearing fetuses with amniotic fluid volume (AFV) abnormalities. The purpose of this study was to determine the relative risks of aneuploidy associated with second-trimester abnormal AFVs and fetal structural anomalies in a cohort of 2,823 singleton, viable fetuses. Compared to gravidas younger than 35 with normal ultrasounds, normal fetuses had an increased incidence of aneuploidy with polyhydramnios, increased AFV, i.e. subjectively increased but normal by maximum vertical pocket (MVP) and/or amniotic fluid index (AFI), oligohydramnios, and decreased AFV, i.e. subjectively decreased but normal by MVP and/or AFI. These included: increased AFV [odds ratio = 12.9, 95% confidence interval (CI) = 4.1-39.4], polyhydramnios (odds ratio = 4.6, CI = 0.6-36.8), and decreased AFV (odds ratio = 3.8, CI = 1.1-13.1). There were no aneuploidies among the 28 normal fetuses with oligohydramnios. Anomalous fetuses had a markedly increased incidence of aneuploidy (odds ratio = 13.4, CI = 7.2-24.9). We conclude that fetal structural anomalies as well as isolated AFV abnormalities were associated with an increased risk for aneuploidy.

Adult↗