Search PubMed⌕ Search

Biomedical subjects

T Ayuso

Publications and source records attributed to T Ayuso.

6 recordsLinked to original sources

Acute carotid obliteration: a new vascular manifestation in POEMS syndrome.

The case of a 65-year-old woman with polyneuropathy, organomegaly, skin changes and monoclonal gammopathy of IgG-lambda type is described. This patient developed an acute carotid obliteration during oral anticoagulation and despite absence of vascular risk factors. Macroangiopathy has been described as a rare systemic manifestation of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal spike and skin changes), affecting the coronary and lower limbs arteries. To our knowledge, this is the second case of POEMS syndrome with a cerebrovascular manifestation.

Anticoagulants↗

[Internal carotid stenosis and giant cell arteritis].

We report on the case of a 69-year-old man admitted with a transient ischemic attack preceded by a two months history of severe headache. Giant cell arteritis was diagnosed by means of temporal artery biopsy. Angiography showed an intra- and extracranial stenosis of the left internal carotid artery. The possible relationship between this stenosis and vasculitis is discussed and stroke as a clinical manifestation of the giant cell arteritis is reviewed.

Aged↗

[A review of the pathogenesis of the hallucinatory state. A description of four case].

INTRODUCTION: A hallucination is a sensorial experience occurring in the absence of external stimuli. It may show as psychological or organic disorders. The main causes are lesions of the central nervous system and of the sensorial organs. The hallucination may present with or without critical perception but always appears to be a real experience. CLINICAL CASE: We describe four patients diagnosed as having hallucinations secondary to known lesions. The first two had visual hallucinations and cerebral ischaemia, the first in the dorso-lateral region of the medulla oblongata and the second in the left parietal lobe. The other two had peripheral sensorial defects. The third patient had simultaneously an ophthalmic disorder and visual hallucinations, and the fourth had chronic hypoacusia and auditory hallucinations. All showed structured sensorial hallucinations with critical appraisal of these hallucinations. CONCLUSIONS: In this paper we review the pathogenesis of the organic hallucinatory state. The main mechanisms are proposed: by means of liberation (destruction of inhibitory structures) and by means of irritation (anomolous excitation of cerebral structures). Also we point out the difference between a hallucination and psychiatric disorders, mainly in three aspects: presence of the known organic lesion, critical appraisal of the perception in spite of it appearing as real to the patient, and the absence of associated psychiatric pathology.

Adult↗

[Paraneoplasic polyneuropathy with anti-amphiphysin antibodies].

Paraneoplastic neurological syndromes consist of a dysfunction of any part of the nervous system, in isolation or in combination, caused by a malign neoplasia, but not by the direct tissular or metastasic invasion of the tumour. Their pathogeny is explained by immunological mechanisms and they are characterised by the presence of high rates of antibodies in serum and cerebrospinal fluid. We present the case of a patient with a sensitive neuropathy that produced ataxia, and who suffered from a poorly differentiated adenocarcinoma of the lung, in whom the search for antineuronal antibodies was positive for antiamphiphysin antibodies, supporting the diagnosis of paraneoplastic polyneuropathy.

Adenocarcinoma↗

[Rhombencephalitis caused by Listeria: clinical-radiological correlation].

Rhombencephalitis due to Listeria is a serious and infrequent infection of the brainstem. It principally affects subjects who were previously healthy. It shows itself clinically in two phases: the first with unspecific symptoms, which could last one week, and the second with the appearance of focal neurologic signs at the level of the brainstem. We present the case of a patient with rhombencephalitis due to Listeria that began initially with headache, nauseas and fever and after ten days the patient showed an asymmetrical affection of cranial nerves, cerebellar signs and sensory deficits in the left hemibody. Subsequently this became complicated with acute respiratory insufficiency, requiring admission to the Intensive Care Unit, and with episodes of urinary retention that required exploration. The early magnetic resonance image showed hypertense patch lesions that were objectified in T2 sequences at the level of the bulb and the pons. Facing a clinical-radiological suspicion of rombencephalitis due to Listeria, treatment was begun with ampicillin and tombramycin. After some days a positive haemoculture for Listeria monocytogenes serotype 4B resistant to ampicilin was detected, therefore it was replaced with vancomycin. The patient survived and on discharge he had oculomotor disorder and micturition problems as sequels. We would like to emphasise the importance of early recognition of the clinical signs of the disease and the early permormance of magnetic resonance, with diagnostic support, to be able to start a suitable antibiotic treatment as quickly as possible.

Encephalitis↗