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T Asbury

Publications and source records attributed to T Asbury.

9 recordsLinked to original sources
PubMed2006

PIPATH: an optimized algorithm for generating alpha-helical structures from PISEMA data.

An optimized algorithm for finding structures and assignments of solid-state NMR PISEMA data obtained from alpha-helical membrane proteins is presented. The description of this algorithm, PIPATH, is followed by an analysis of its performance on simulated PISEMA data derived from synthetic and experimental structures. pipath transforms the assignment problem into a path-finding problem for a directed graph, and then uses techniques of graph theory to efficiently find candidate assignments from a very large set of possibilities.

Algorithms↗
PubMed2006

Intensity and mosaic spread analysis from PISEMA tensors in solid-state NMR.

The solid-state NMR experiment PISEMA, is a technique for determining structures of proteins, especially membrane proteins, from oriented samples. One method for determining the structure is to find orientations of local molecular frames (peptide planes) with respect to the unit magnetic field direction, B0. This is done using equations that compute the coordinates of this vector in the frames. This requires an analysis of the PISEMA function and its degeneracies. As a measure of the sensitivity of peptide plane orientations to the data, we use these equations to derive a formula for the intensity function in the powder pattern. With this function and other measures, we investigate the effect of small changes in peptide plane orientations depending on the location of the resonances in the powder pattern spectrum. This gives us an indication of the change in lineshape due to mosaic spread and a way to interpret these in terms of an orientational error bar.

Ion Channels↗
PubMed1979

System of notation for photocoagulation in the presumed ocular histoplasmosis syndrome.

Using a notation system for evaluation of photocoagulatin of the choroidal neovascular membrane (CNVM) in presumed ocular histoplasmosis syndrome (POHS) demonstrated several advantages, which are: (1) a projector system which allowed excellent magnification of the CNVM and its distance from the foveal avascular zone (FAZ); (2) direct study of fluorescein angiographic negatives; (3) good comparison of pretreatment of posttreatment lesions in relation to FAZ; (4) a precise measurement of the surface area of each CNVM and its distance from the FAZ; and (5) an accurate and rapid way of recording and comparing data. This notation system appears valuable as a means of standardizing the examination and photographic findings from multiple institutions. Results of photocoagulatin of the CNVM are presented. Photocoagulatin of the entire CNVM appeared more effective than partial photocoagulatin of the CNVM.

Adolescent↗
PubMed1975

Cystic retinoblastoma.

A grossly cystic retinoblastoma, presumably a form of the diffuse infiltrating type, mimicked uveitis in an 81/2-year-old boy. A review of 44 cases indicated that grossly (clinically) detectably cysts are rare in this neoplasm, although microcysts are relatively common. Lesions of this nature, especially if presenting with a history of trauma, as in our patient, may lead the ophthalmologist to diagnose uveitis. The diagnosis of retinoblastoma may thus be unduly delayed.

Child↗
PubMedDate not supplied

A condensed history of ophthalmology in Cincinnati (1827-1999).

The history of ophthalmology in Cincinnati dates back to 1827, when Dr. Daniel Drake founded the Eye Institute of Cincinnati. Since that time, many other individuals have influenced the course of ophthalmology in the city and region. Included among these were Elkanah Williams, first chairman of the Department of Ophthalmology at Miami Medical College of Ohio (the forerunner of the University of Cincinnati), William Seeley, Robert Sattler, Christian Holmes, Derrick T. Vail and his illustrious son Derrick T. Vail, Jr., Clarence King, Karl Ascher, Donald Lyle, and Mary Knight Asbury. The author presents brief biographical summaries and interesting anecdotes about each of these individuals and several others of importance to Cincinnati ophthalmology.

History, 19th Century↗