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Biomedical subjects

T Arima

Publications and source records attributed to T Arima.

At least 325 records · Page 18Linked to original sources
PubMed1980

Undifferentiated (embryonal) sarcoma of the liver.

A 10-year-old girl with undifferentiated (embryonal) sarcoma of the liver reported here had abdominal pain, nausea, vomiting and weakness when she was 8 years old. Chemical analyses of the blood and urine were normal. Serum alpha-fetoprotein was within normal limits. She died of cachexia 1 year and 8 months after the onset of symptoms. Autopsy showed a huge tumor mass in the liver and a few metastatic nodules in the lungs, which were consistent histologically with undifferenitated sarcoma of the liver. To our knowledge, this is the second case report of hepatic undifferentiated sarcoma of children in Japan, the feature being compatible with the description of Stocker and Ishaka.

Child↗
PubMed1980

Studies on duodenal cyclic AMP content content in pancreatic disease after administration of pancreozymin and secretin.

Cyclic AMP (cAMP) output in the duodenal contents of 11 normal subjects, 18 patients with chronic pancreatitis, six convalescing from acute pancreatitis and five with pancreatic carcinoma was measured after a single dose of pancreozymin and secretin. The technic was indirect, utilizing recovery of duodenal contents by the Dreiling tube rather than direct measurements of fluid that was not contaminated by bile. In all patients groups, cAMP output reached a peak after this stimulation with a concomitant increase of bicarbonate and amylase outputs. A significantly decreased cAMP output was observed in all pancreatic disease groups compared to the normal group. Patients with chronic pancreatitis showed a slightly decreased cAMP output, considerably decreased bicarbonate output and normal amylase output. In acute pancreatitis cAMP output was reduced with normal bicarbonate and amylase outputs. In pancreatic carcinoma cAMP decreased significantly, bicarbonate output was moderately reduced and amylase output was normal. cAMP output in all groups studied did not correlate with either bicarbonate output or amylase output.

Acute Disease↗
PubMed1980

Metabolic differences in deoxyribonucleoside triphosphate hydrolysis between rat liver and Yoshida sarcoma cell chromatins.

Enzymatic activities for deoxyribonucleoside triphosphate hydrolysis associated with Yoshida sarcoma and normal rat liver chromatins were comparatively studied. Deoxyribonucleoside triphosphate-hydrolyzing activities were isolated from purified chromatins of Yoshida sarcoma cells and normal rat liver, and gel-filtered on Sephadex G-200 columns. A single peak of dUTP-hydrolyzing activity from the Yoshida sarcoma chromatin and three peaks from the normal liver chromatin were observed. The first peak from the normal chromatin hydrolyzed dATP, dCTP and TTP mainly to the corresponding deoxyribonucleoside diphosphates, and dUTP and dGTP to the corresponding di- and mononucleotide forms. The activity in the first peak from the normal liver chromatin had an apparent Km of 2.5 X 10(-4) M for dUTP, required divalent cations and was inhibited by NaF. The peak from the Yoshida sarcoma chromatin corresponding to the first peak from the normal liver chromatin hydrolyzed all five deoxyribonucleoside triphosphates to deoxyribonucleoside diphosphates with minor co-production of mononucleotides. The enzyme activity from the malignant cells had an apparent Km of 2.5 X 10(-5) M for dUTP, required Mg2+, but was not inhibited by NaF.

Animals↗
PubMed1980

Inhibition by biscoclaurine alkaloid of lipid peroxidation in biological membranes.

Biscoclaurine-type alkaloids were examined for ability to act as membrane-stabilizing agents and to protect against lipid peroxidation and deterioration of biological membrane. The following results were obtained. Biscoclaurine-type alkaloids inhibit Fe2+-induced lipid peroxidation of biological membrane. Cepharanthine protects against decrease in membrane compartmentation due to Fe2+-induced lipid peroxidation. Peroxidation of membrane lipid causes decrease in membrane fluidity but cepharanthine protects against this decrease. These protective actions are structure specific. They are also biscoclaurine-type specific and do not apply to coclaurine-type alkaloids such as papaverine. Based on these findings, the biological action of the alkaloid is discussed relative to membrane-stabilizing action and protective action against leukopenia induced by X-ray irradiation or mitomycin treatment in cancer therapy.

Alkaloids↗
PubMed1979

Congenital pyloric atresia--a report of two cases.

Two cases of the membranous type of pyloric atresia are described and a review of 99 cases reported in the literature is presented. Excision and incision of diaphragm with pyloroplasty was performed on both cases. The first patient was alive following the second operation of gastroduodenostomy for postoperative stenosis. The second premature patient died of sepsis on the 58th postoperative day. The treatment should be surgical and the operative procedure should be chosen depending on the type of atresia. Excision or incision of the diaphragm with pyloroplasty and gastroduodenostomy are the procedures of choice. Gastrojejunostomy should be avoided because of its high mortality rate.

Duodenum↗
PubMed1979

Studies on circulating soluble immune complexes of the liver disease. 1. Inhibition assay of polyclonal rheumatoid factor binding to IgG-sepharose.

Polyclonal rheumatoid factor (pRF) was isolated from sera seropositive for RF and it was radioiodinated with lactoperoxidase method. Using the 125I-pRF and IgG-p-azobenzamidoethyl Sepharose 6B, a competitive inhibition radioassay for detecting immune complexes is described. The assay can be performed in 90 min utilizing 10 microliter of serum with good reproducibility and endogenous RF in test serum did not interfere the reaction. The test can detect complexes nearly to 8s and as low as 0.1 microgram/ml of aggregated human IgG. Decomplementation by heating test sera is unnecessary. The assay was performed at 4 degrees C but less inhibition activity was obtained when it was carried out at 24 degrees C.

Antigen-Antibody Complex↗
PubMed1979

Studies on circulating soluble immune complexes of the liver disease. 2. Serum inhibitory activity of polyclonal rheumatoid factor binding to IgG-sepharose.

Circulating immune complexes were tested in the liver disease by measuring polyclonal rheumatoid factor (pRF) inhibition activity. The test is based on the inhibition of 125I-pRF binding to IgG-p-azobenzamidoethyl Sepharose 6B. Normal levels of the test were less than 23%. The inhibition activity in sera with liver disease was found to correlate with severity of the disease, as defined by histological criteria. There were correlations of the activity with serum gamma-globulin concentration, seropositivities for rheumatoid factor and hepatitis B antigen.

Antigen-Antibody Complex↗
PubMed1979

Serum glycoproteins in the liver diseases. VII. Further studies on the properties of desialylated glycoprotein binding activity in particulate fraction of human liver homogenate.

Binding of desialylated alpha 1-acid glycoprotein by human liver particulate fraction exhibited a dependence on the presence of calcium chloride whereas Cu+, Mn+, Zn+ Fe+ and Co+ inhibited the binding. The other cations such as K+, Na+, Ba+, Mg+ or Pb+ were determined to be non-effective on the binding activity. The pH of the assay for binding was not critical in the range of 6.5 to 9.5. The binding process required the presence of terminal sialic acid on the particulate protein. Fifty nine per cent of binding activity in the original liver paticulate fraction were recovered in acetone powder. Extraction of the acetone powder with a buffer containing EDTA resulted in an increased total binding activity. After extraction with 1--10% Triton X-100, 60% of the activity were still detected in insoluble fraction.

Animals↗
PubMed1979

Serum glycoproteins in the liver diseases. VIII. Desialylated glycoproteins in the liver cirrhosis.

Serum desialylated glycoprotein livel of cirrhotic patients was determined and a diagnostically significant elevation of these proteins was observed. The level of these patients was usually 2--10 times of that seen in normal subjects and the elevation was signifi-ant (p less than 0.001) when compared to the level in patients with chronic aggressive hepatitis, severe (2B). Serial determinations of these proteins in the cirrhotic patients showed no correlation between them and SGPT as a whole but in several cases in which SGPT fluctuated the former associated with the latter. In patients with decompensated cirrhotic liver these proteins returned nearly to the level of compensated patients when it was improved. The level of these proteins in cirrhotic patients correlated, not always, with serum albumin (r = -0.46, p less than 0.02) and indocyanine green clearance rate (r = -0.73, p less than 0.05), but not with SGPT as well as the other liver function tests.

Female↗