Are drugs targeted at Alzheimer's disease useful? 2. Insufficient evidence of worthwhile benefit.
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Biomedical subjects
Publications and source records attributed to T Arie.
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Psychogeriatrics--the psychiatry of old age--became an official specialty in the NHS in 1989. Until the 1960s interest in the mental disorders of old age had been largely confined to research, but today special psychiatric services for old people are widely established, and the care of mentally ill old people is recognized as a major issue by professional workers, governments and the lay public, not only in developed countries but also in the Third World. Britain has led this movement.
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Details of consumption of hypnotic drugs derived from a nationally representative sample of elderly people were analysed in terms of the prevalence, duration, and likely frequency of use. Of 1020 randomly selected subjects aged 65 and over 16% (166) reported using (mainly benzodiazepine) hypnotic drugs, and of these 89% reported having taken such a drug the night before the interview. Most of these users (73%) had been taking hypnotic drugs for more than one year, with 25% reporting drug use for more than 10 years. These results suggest that for most elderly users of hypnotic drugs, patterns of consumption encourage the development of cumulative effects and benzodiazepine dependence.
The last ten to fifteen years have been a time of rapid development in the psychiatry of old age. Biological research on the dementias has moved forward impressively, but significant too has been the development in many countries of local services specially designed to meet the needs of old people with mental disorders, and of those who look after them. Such services are built on the experience both of psychiatry and of geriatrics, but have also broken new ground: the UK experience is described. The facts have belied earlier misgivings about the potential of this field of work to attract and satisfy able staff in the health professions; indeed, this work has developed with style and enthusiasm, and with widespread educational programmes and growing research activity. This paper reviews briefly these developments and considers some broader issues of policy as they bear on the care of mentally ill old people. Considered also is tentative evidence that the dementias of old age may be becoming less prevalent. Finally, current studies in Nottingham which look at the social associations of old age mental disorders are briefly described and the implications are considered of the broadening of the base of 'psychogeriatrics' which such studies represent.
Profiles of sleeping habits, subjective sleep quality, and mental and physical well-being were obtained from 1023 elderly individuals randomly sampled from the Nottinghamshire Family Practitioner Committee's records. Subjective insomnia at least 'sometimes' was reported by 37.9% of the sample. Discriminant analysis of selected health and demographic variables indicated that symptoms of anxiety, sex and self-ratings of health were the factors most influential in predicting reports of problem sleep. Thus, respondents classified as subjective insomniacs tended to have significantly higher anxiety scores, to be women, and to rate their health as below average. Relative to the non-insomniac respondents, those complaining of sleep problems also perceived their sleep latency as longer, and their total sleep as shorter. These results emphasize that, in addition to apparently 'normal' age-related changes in the structure of sleep, subjective insomnia in old age may often be mediated by the physical and psychological disorders which can accompany ageing.
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Using four brief assessment scales, profiles of mental health and psychological well-being were obtained from 507 old (aged 65-74 years) and 535 very old (aged 75+) individuals randomly sampled from the community. Assessments of dementia and depression were subsequently validated against diagnostic ratings made by experienced psychogeriatricians. Levels of agreement between psychometric and clinical ratings of dementia (kappa = 0.83) and depression (kappa = 0.66) were satisfactory. The old and very old groups reported similar levels of anxiety and personal disturbance, and showed a similar prevalence of depression. However, those aged 75+ showed higher levels of dementia and significantly lower levels of social involvement and morale.
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A multi-centre controlled trial of amitriptyline, dothiepin and mianserin in the treatment of depressive illness was undertaken in psychiatric inpatients over the age of 65. Despite the co-operation of many of the leading practitioners in this field in Great Britain, it proved impossible to recruit sufficient patients for firm conclusions to be drawn. Forty-five patients were entered into the trial, 13 withdrew because of lack of improvement, 4 because of intercurrent physical illness, 3 because of adverse effects of trial medication and 2 because of lack of compliance. Only 11 of the 23 patients completing had a final score on the Hamilton Depression Rating Scale of 10 or less. No treatment showed a significant superiority over the others, nor was there any difference in tolerance.
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This paper is an exploratory attempt to examine international differences in the proportion of old people living in non-private households. The aim of the study was to provoke further discussion of the role which institutions play in the care of the elderly in various settings and to examine the effect of certain demographic and economic parameters on the proportion of elderly people in non-private households. Data were drawn from national censuses and indirect standardization was used to allow comparison of the probability of institutionalization in the countries considered. Considerable variation in standardized institutionalization ratios was found but this variation was not significantly associated with any of the demographic or economic variables considered.
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