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Biomedical subjects

T Aoki

Publications and source records attributed to T Aoki.

At least 1,171 records · Page 65Linked to original sources
PubMed1978

Studies on carrier protein in contact dermatitis: localization of soluble epidermal carrier proteins by macrophage migration test.

The migration of peritoneal exudate cells from picrylchloride-sensitive guinea pigs was inhibited by heteroantigenic components which were isolated by antinormal guinea pig epidermis antibody immunoadsorbent from soluble epidermal proteins of picrylchloride painted guinea pigs. The components were demonstrated by indirect immunofluorescence study to localize in the intercellular spaces of guinea pig epidermis. It is consequently suggested that carrier protein(s) of contact hypersensitivity reside on the cell surface of epidermis.

Animals↗
PubMed1977

Surface antigens on transplantable tumor cell lines producing mouse type C viruses.

A variety of transplantable mouse tumor lines were shown to contain murine type C viruses and virus-associated antigens. The type of virus isolated and antigens detected could not invariably be correlated with the original method of tumor induction, but testing of the majority of tumor lines for infectious virus at various levels of in vivo or in vitro passage yielded isolates that were consistent in tissue culture host range for each tumor. In contrast, during the course of in vivo transplantation, some of the lines underwent considerable change in the pattern of virus-associated cell-surface antigens. When the transplanted tumor lines were placed into culture, all showed some alteration in the detectable surface antigens. Upon retransplantation and passage of the cultured cells in mice, the surface antigens gradually returned to the original in vivo patterns and occasionally acquired additional type C virus-associated antigens not detected in the original tumor line. To test for association of antigens with infectious virus, appropriate tissue culture cell lines were infected with the viruses isolated from the tumors. In these infected indicator cells, some new virus-associated cell-surface and virion evelope antigens were detected, but the complete array of antigens found in the original tumor lines was not acquired. These findings indicated the presence of several different type C viruses in long transplanted cell lines and demonstrated that environmental and host cell factors may have major influences on expression of virus-associated antigens.

Animals↗
PubMed1977

Detection of R plasmids in naturally occurring fish-pathogenic bacteria, Edwardsiella tarda.

The conjugative R plasmids were detected from fish-pathogenic Edwardsiella tarda isolated from cultured eels. These R plasmids were resistant to sulfonamide and tetracycline, or sulfonamide, streptomycin, chloramphenicol, tetracycline and kanamycin. There were no inhibitions in growth of phages W-31, P1, T1, T3, T7, and lambda. They were classified into incompatibility group A.

Animals↗