Intracardiac repair of tetralogy of Fallot associated with unilateral absence of pulmonary artery.
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Blood Vessel Prosthesis↗
Biomedical subjects
T Akimoto
Publications and source records attributed to T Akimoto.
[Immunological study of Behcet's disease].
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Acute Disease↗
DT-5461a, an antitumor synthetic lipid a analog, causes selective blood flow reduction in tumor tissue.
We previously reported that a synthetic low-toxicity lipid A analog, DT-5461a, exhibited a significant antitumor effect was characteristically accompanied by extensive tumor necrosis, suggesting that DT-5461a causes a local circulatory disturbance in tumor tissues. In this study, we investigated the effect of DT-5461a on regional blood flow in various organs including tumor tissue with a radiolabeled tracer-distribution technique using 14C-iodoantipyrine. Intravenous administration of DT-5461a induced blood flow reduction in Meth A tumor subcutaneously implanted into BALB/c mice, but not in liver, spleen or lung of these mice. This tumor tissue-specific reduction in blood flow was significantly inhibited by pretreatment with antisera against tumor necrosis factor (TNF) alpha, interferon (IFN) alpha/beta, and IFN gamma. These results indicate that endogenously induced cytokines, namely TNF alpha and IFNs, are involved in the intratumor blood flow reduction caused by DT-5461a.
Animals↗
Segmental flow-resistance relationship in pulmonary lobar transplantation: possibility for donor lobe evaluation in pediatric lung transplantation.
Pulmonary lobar transplantation is an option for pediatric lung transplantation, and it has the potential of extended applications. We compared the relationship between segmental blood flow and segmental vascular resistance of the pulmonary lobe with that of the transplanted single lung. Eight of 14 puppies received a left upper pulmonary lobe from double-weighed adult dogs, and the other six puppies received a left lung from puppies. All recipient dogs were treated with oral cyclosporine (15 mg/kg/day) and intramuscular prednisolone (1.0 mg/kg/day), after the operation. Pulmonary arterial and left atrial pressures and segmental flow of the lungs were measured at rest and while the inferior vena cava or right pulmonary artery was clamped, before and 1 hour and 2 weeks after lung transplantation. Vascular resistance of the lung segment was calculated at each hemodynamic state. Segmental resistance of the lung at rest significantly increased from pretransplantation to 1 hour after transplantation (pulmonary lobe group, 2211 +/- 42 to 2555 +/- 61 dyne.sec.cm-5; single lung group, 2126 +/- 56 to 2557 +/- 72 dyne.sec.cm-5) and recovered 2 weeks after transplantation in both groups. However, by means of partial clamp of the right pulmonary artery, segmental resistances of 1 hour after transplantation pulmonary lobe (2248 +/- 37 dyne.sec.cm-5), and single lung (2206 +/- 34 dyne.sec.cm-5) at the same segmental flow of the pretransplantation state (310 to 320 ml/min) were equivalent to those of the pretransplantation lungs. There was no significant difference in the segmental resistance at any segmental flow between the pulmonary lobe and single lung before and after lung transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
Systemic administration of a synthetic lipid A derivative, DT-5461a, reduces tumor blood flow through endogenous TNF production in hepatic cancer model of VX2 carcinoma in rabbits.
Intravenous administration of DT-5461a, synthetic low-toxicity lipid A derivative, significantly inhibited the growth of VX2 tumor transplanted in the liver of rabbits. DT-5461a induced high levels of TNF activity in tumor tissue from 30 to 60 min after the administration, while no TNF activity was detected in the adjacent nontumorous liver tissue. Simultaneous measurement of microcirculatory blood flow in both tumorous and nontumorous regions in the liver by laser doppler velocimetory revealed that intravenous administration of DT-5461a caused a significant blood flow reduction in tumor region, but not in nontumorous counterparts. Tumor blood flow was significantly reduced by 40 to 60% at 30 to 90 min after the DT-5461a administration as compared with preadministration value. In contrast, local administration of human recombinant TNF alpha through the hepatic artery induced blood flow reduction not only in tumor region but also in nontumorous liver tissue. These results suggest that systemic administration of DT-5461a induced selective tumor microcirculatory blood flow reduction via local endogenous TNF production.
Animals↗
Adult embryonal rhabdomyosarcoma showing marked response to radiotherapy: a case report.
A case of embryonal rhabdomyosarcoma (RMS) arising from adult lower proximal extremity is described. Rhabdomyosarcoma (RMS) is most common among children, but adult embryonal RMS is rare. The patient was a 44-year-old man with a large tumor of the left extremity invading to the pelvis. The histological diagnosis was embryonal RMS. Radiation therapy was delivered a total dose of 50 Gy to the tumor. Although adult RMS, usually pleomorphic type, is considered to be radioresistant, the tumor showed marked response to radiotherapy and local control was achieved easily in this case.
Adult↗
A quantitative study of radiation-induced apoptosis in two rat yolk sac tumour cell lines with different radiosensitivities in vitro.
Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line, NMT-1 cells, showed morphological changes characteristic of apoptosis by fluorescence microscopic observation at 24 hours after irradiation with a single dose of 10 Gy. Development of apoptosis in NMT-1 cells was observed as a function of time within 24 hours after irradiation. There was a significant increase in the amount of apoptosis between 2 and 5 Gy only in NMT-1 cells but increasing the radiation dose from 5 Gy to 10 Gy did not result in increased apoptosis. A radioresistant NMT-1R cells, on the other hand, displayed a small apoptotic response to an irradiation dose of 10 Gy at 24 hours after irradiation.
Animals↗
Long-term outcome of postorchiectomy radiation therapy for stage I and II testicular seminoma.
To evaluate the treatment-related late sequelae including gonadal function and second malignancy 94 patients with stage I and II testicular seminoma treated with postorchiectomy radiation therapy were analyzed retrospectively. The 10-year cause specific, disease free and actuarial survival rates were 100, 98.5 and 96.1% for stage II and 91.7, 83.3 and 91.7% for stage II, respectively. The most common late sequelae of gastrointestinal tract was peptic ulcer, developing in 16% of all patients with a median interval of 12 months, but severity was mild except one who needed subtotal gastrectomy. Second malignancies developed in 9 patients (9.5%) with a median interval of 13 years, but calculated O/E ratio excluding 2 patients with secondary germ cell tumor of contralateral testis was 2.3 and did not reach a significant level statistically. Concerning gonadal function assessed from the number of the children, 79% of the patients who wanted to have children after the treatment were successful in fathering children. No fatal complications were observed.
Adult↗
Clinical FDG-PET in diagnosis and evaluation of radiation response of patients with nasopharyngeal tumor.
BACKGROUND: We investigated the utility of clinical FDG-PET in patients with nasopharyngeal tumor treated by radiotherapy, retrospectively. MATERIALS AND METHODS: Fifteen patients with known or suspected nasopharyngeal tumors underwent FDG-PET. PET images were evaluated with visual interpretation qualitatively. Semiquantitative analysis was also performed on the metabolic ratios (MRs). RESULTS: The sensitivity and specificity of FDG-PET based on visual inspection were 92.9% (13/14) and 83.3% (10/12), respectively. There was a statistically significant difference between histological types in the mean MR. MR was significantly decreased by radiotherapy in patients with poorly differentiated squamous cell carcinoma. PET scans obtained 1-3 months after radiotherapy indicated decreased levels of FDG uptake in all tumors but one scan did not accurately reflect the status of the disease. CONCLUSION: These results are encouraging as to the clinical usefulness of FDG-PET for evaluating radiation effects in patients with nasopharyngeal tumor.
Adult↗
Transvaginal ultrasonography of female urethral carcinoma treated with radiation therapy: report of two cases.
Female urethral carcinoma is an uncommon disease that often cannot be detected precisely by computed tomography and MR imaging. Therefore, we applied transvaginal ultrasonography (TVUS) using a real-time scanner with 7.5 MHz transducer to two female patients with urethral carcinoma who were treated with radiation therapy, to evaluate tumor extension and radiation response. Sagittal images of the urethra along a 3.0 cm long axis were obtained through the vaginal anterior wall with penetration of about 4.0 cm. TVUS demonstrated the tumor locations and dimensions, especially whether the tumor was located in the distal half of the urethra or involved the proximal urethra. TVUS was also useful for the assessment of radiation response.
Aged↗
Radiation therapy and concurrent daily intra-arterial infusion of low-dose cisplatin following alteration of pelvic blood flow for invasive bladder cancer: a preliminary report.
Concurrent intra-arterial infusion chemotherapy and radiation therapy following alteration of pelvic blood flow was performed in 15 patients with invasive bladder cancer (T2: 2, T3a: 4, T3b: 5, T4: 4). Infusion chemotherapy consisted of a daily low-dose of cisplatin with a dose range of 7 to 9 mg per patient. Of the 15 patients, 11 achieved complete response (73%) and other had partial response. Four of those with CR developed recurrence (local recurrence in three and distant metastasis in one patient). Cause specific and disease-free survival at 3-years were 56% and 49.9%, respectively, and the bladder preservation rate at 3-year was 47%. Toxic reactions related to the treatment was of a reasonable level, and cisplatin-induced renal dysfunction was not experienced, even in the patients with poor renal function, although transient neutropenia and thrombocytopenia occurred in all patients at the latter stage of the treatment. This treatment modality is considered to be effective and feasible even in patients with locally advanced disease and/or those unsuited for cisplatin-based systemic chemotherapy.
Adult↗
Does AK-2123 (Senazole) have sensitizing effects on radiation, cisplatin and hyperthermia under aerobic conditions in vitro?
We investigated the sensitizing effects of AK-2123 (Senazole) on the interaction of radiation, cisplatin and hyperthermia under aerobic conditions in the rat yolk sac cell line NMT-1R in vitro. The effects were assessed by clonogenic assay. A cytotoxic effect of AK-2123 after 24 hours exposure was observed as a function of the dose. For NMT-1R cells, the ID70 of AK-2123 was 400 micrograms/ml for 24 hours exposure, which was employed for subsequent combined treatments. Although a statistically significant increase in the G1 cell fraction was observed after AK-2123 treatment with a dose of ID70 (p = 0.02) no enhancing effect of AK-2123 on radiation, cisplatin or heat response curves was detected under aerobic conditions in vitro.
Animals↗