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Biomedical subjects

T Agishi

Publications and source records attributed to T Agishi.

At least 109 records · Page 6Linked to original sources
PubMed1991

[Autologous blood transfusion aided with erythropoietin in transurethral resection of the prostate].

Erythropoietin (EPO) with an established clinical efficacy in renal anemia has in recent years become applied as an aid to autologous blood transfusion in surgical patients. This report describes our experience with autotransfusion along with the use of EPO in transurethral resection of the prostate (TUR-P), indicating its usefulness. Ten patients with benign prostatic hypertrophy aged 60 to 74 years received 3000 units of EPO, with an iron preparation, nine times beginning 3 weeks prior to operation. Autologous blood of 300 ml was collected from the patient each at 2 and 1 week before operation and was used at TUR-P. Five other patients who underwent TUR-P with the same volume of autotransfusion accompanied by preparative medication with the iron alone served as controls. In the EPO treated group (mean age, 68.3 years) the mean value for hemoglobin concentration (Hb) was 14.0 +/- 1.6 g/dl on the day of operation, which showed a recovery rate of 94.9 +/- 5.4% (Hb recovery rate) as against the pre-EPO treatment value (mean: 14.8 +/- 1.3 g/dl). This Hb recovery rate was significantly greater (p less than 0.001) when compared to 82.2 +/- 2.5% in the control group (mean age, 68.2 years). Of the EPO treated patients, those in their sixties (n = 6; mean age, 66.3 years) exhibited a significantly higher Hb recovery rate (98.3 +/- 3.5%) than the rate (89.9 +/- 3.0%) for patients in their seventies (N = 4; mean age, 71.3 years) (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Transfusion, Autologous↗
PubMed1991

Improved on-line thoracic duct drainage for lymphocytapheresis.

Lymphocytapheresis using thoracic duct drainage (TDD) is a recognized technique of extracorporeal immunomodulation for various autoimmune diseases such as rheumatoid arthritis (RA), and its clinical benefit has been reported and generally accepted. Lymphocytapheresis using TDD is very selective for removing lymphocytes (especially helper T-cells) but raises some problems such as hypoproteinemia due to the massive removal of lymph, and difficulties in repeated treatment. Along with the development of a new polyester fiber filter, we have developed a simple and effective method of lymphocytapheresis for wide adoption for these techniques. We performed lymphocytapheresis using TDD in patients with RA and previously reported its clinical efficacy indicated by the significantly lower number of peripheral lymphocytes and T4/T8 ratio. We present here our newly-developed on-line system designed to prevent hypoproteinemia. Furthermore we report on the advantages with a new subcutaneous vascular access device set up to manage the problems of repeated treatments. A small reservoir for keeping the thoracic duct open and returning lymph to the patient permitted sufficient lymph drainage and removal of lymphocytes and the clinical application of TDD is discussed.

Arthritis, Rheumatoid↗
PubMed1991

[Mutual supplementation in treatment of renal failure by blood purification and kidney transplantation].

More than 100,000 uremic patients have been maintained by various blood purification modalities in Japan. However, their quality of life is far from satisfaction not only in terms of physical problems related to the complications specific to long-term dialysis treatment, but also the restriction in social activities by spending much time for hospital dialysis. A graft functioning rate in kidney transplantation has been remarkably improving after introduction of Cyclosporine A as an immunosuppressant and is presently approximately 90% one year after transplantation. As long as the transplanted kidneys function, further extensive social activities and highly-graded quality of life is warranted compared to artificial kidney treatment. On the other hand, patients in end-stage renal diseases and with rejected transplants are expected to undergo safe kidney transplantations as being maintained by dialysis therapy. Furthermore, recent development in blood purification technology has made the specific kidney transplantations successful in recipients with the preformed antibody (-ies) and the incompatible ABO blood type antibody (-ies). Nowadays, relation between blood purification and kidney transplantation is not competitive, but mutually supplementary as a matter of realism.

Humans↗
PubMed1990

A low CA++ level in effluent as a risk factor for the peritonitis in CAPD patients.

In vitro, some studies revealed the importance of the CA++ level in peritoneal macrophage functions in CAPD patients. We therefore retrospectively studied the relationship between the frequency of peritonitis and the concentration of Ca, Ca++, Interferon-r (IFN-gamma), Interleukin-1B (IL-1B) in the Pd effluent. Samples were taken during a peritonitis-free period. In a group of patients without peritonitis, the mean Ca++ level in the Pd effluent was 2.25 +/- 0.20 mEq/L, while in the other group with frequent episodes of peritonitis (more than one episode per 20 patient-months), the mean Ca++ level in PD effluent was 2.01 +/- 0.13 mEq/L which was significantly lower than the former (p less than 0.05). The mean Ca concentration in Pd effluent was also lower in the group with the high frequent peritonitis than the peritonitis-free group, but not significantly. The level of IFN-gamma is lower and IL-1B is higher in the group with frequent peritonitis than in the peritonitis-free group, although these differences were not significant. These evidences suggest that lower Ca++ level in the effluent of the frequent peritonitis group may impair the peritoneal macrophage function and peritoneal cell-mediated immune function and may increase a risk of the peritonitis. These results may offer a new approach for prophylaxis of peritonitis in CAPD patients.

Calcium↗