[Combined use of nuclear medicine and ultrasound in the diagnosis of hepatic tumor (author's transl)].
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Biomedical subjects
Publications and source records attributed to T Aburano.
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The neck uptake ratio of 99mTcO4- was measured using a gamma camera and pinhole collimator. The patient was sit 2 m apart from the collimator surface and radioactivity was counted 20 minutes after injection. The whole body count with lead shield (Cc) and without shield (Cd), and natural background count (CBG) were measured. As the shield was utilized the B filter for conventional thyroidal 131I uptake test (lead plate of 1.3 cmx10 cmx10 cm) and it was placed over the anterior neck to cover the thyroid gland at the measurement of (Cc). Then 99mTcO4- neck uptake ratio was calculated as following: (formula: see text) The mean values were 5.3%, 4.5%, 3.1%, 11.2% and 20.7% in the group of euthyroid, hypothyroid, subacute thyroiditis, hyperthyroid state with chronic thyroiditis and Graves' disease, respectively. This method is very convenient and simple to perform following scintigraphy of the thyroid gland with pinhole collimator.
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Alpha1 (alpha 1) fetoprotein (AFP) radioimmunoassay method was routinely used in addition to liver scintigraphy to detect a primary hepatic cell carcinoma, and the diagnostic accuracy of both methods was compared. Twenty-one of 27 cases (78%) with primary hepatic cell carcinoma showed a positive AFP titer of over 200 ng/ml. In 3 of these AFP-positive cases, no focal defects could be found in liver scintigraphy, although subsequently performed celiac angiography revealed hypervascular shadows. On the contrary, 22 of 27 cases (81%) represented well-defined focal defects on scintigraphy. In 4 of these cases with a positive scan, the result of AFP was found to be negative. The overall diagnostic accuracy for detecting primary hepatic cell carcinoma with a combination of both methods was 93%.
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