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Biomedical subjects

T A Watson

Publications and source records attributed to T A Watson.

At least 19 recordsLinked to original sources
PubMed1994

Ablation of luteal phase symptoms of Menière's disease with leuprolide.

Symptoms of Menière's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Menière's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Menière's symptoms. This drug, which abolishes gonadotropin-dependent ovarian sex steroid production, alleviated the patient's symptoms during therapy. This observation offers further support to the hypothesis of sex hormone-related exacerbations of Menière's symptoms and provides a possible future treatment option for this debilitating disease.

Adult↗
PubMed1994

Hay fever: pharmacotherapy or immunotherapy?

The total management of the patient with hay fever involves a multifaceted approach including environmental control, pharmacotherapy, and immunotherapy. Pharmacotherapy and immunotherapy are complementary methods which the allergist may utilize as appropriate to each individual patient's needs.

Allergens↗
PubMed1987

Effects of pH and feeding regime on methylmercury accumulation within aquatic microcosms.

The effect of pH (pH 5, 6 or 7) on accumulation of radiolabelled methylmercury was examined using a laboratory microcosm system. Accumulation of labelled mercury at three trophic levels, primary consumers (Daphnia magna), secondary consumers (rainbow trout, Salmo gairdneri) and tertiary consumers (walleye, Stizostedion vitreum) was not significantly affected by pH. Our results are in direct contrast with field observations of elevated methylmercury concentrations in fish from low pH water and indicate that the elevated mercury residues observed in the field result from factors other than the direct effects of pH on accumulation of methylmercury by aquatic organisms. Both water and diet were important as sources of the labelled mercury which was accumulated by walleye. Walleye which were fed rainbow trout, that had accumulated labelled mercury from within the experimental microcosms, accumulated almost twice as much labelled mercury as walleye fed non-labelled prey, or walleye which were not fed. Walleye fed non-labelled rainbow trout accumulated slightly more labelled mercury than walleye which were not fed, presumably as a result of the higher metabolic rate of the fish which were fed.

Journal Article↗
PubMed1982

In vitro effects of acephate on carbonic anhydrase activity in the blood and gills of rainbow trout, Salmo gairdneri.

Acephate, a water-soluble organophosphate pesticide used to control terrestrial insect pests, may enter aquatic ecosystems in the course of its use and adversely affect fish populations. The in vitro effects of this insecticide on gill and red blood cell (RBC) carbonic anyhdrase (CA) activity in rainbow trout were investigated over a range of 100 mg/1 (0.55 mM) to 50,000 mg/l (273 mM) to assess the manner in which acephate might affect respiratory capacity in exposed fish. Concentrations required to produce 50% inhibition of CA activity in the gill and RBC preparations were 38,000 mg/l (207 mM) and 8,900 mg/l (48 mM) respectively. The toxic action of acephate may be related to inhibition of CA activity in the blood and gills with resultant disturbances of respiratory capacity and salt balance.

Animals↗
PubMed1977

The effect of radiotherapy in the treatment of adenoid cystic carcinoma of the head and neck arising in minor salivary glands.

Eighteen cases of adenoid cystic carcinoma of the minor salivary glands are reviewed. Noteworthy in the history is the report of pain at the site of the lesion which radiates elsewhere, or of numbers or tingling in its area. Radiation therapy is as able to control the primary as local surgery. Involvement of a much wider field than is required to treat the primary may control the perineural spread common to this tumor and avoid the massive procedures necessary to cure it by surgical means. Metastases to the lung, bone, and brain by venous spread can probably be avoided only by early diagnosis.

Adult↗
PubMed1976

The activity of delta 5-3 beta hydroxysteroid dehydrogenase enzyme in the interrenal tissue of rainbow trout (Salmo gairdneri Richardson) exposed to sublethal concentrations of zinc.

The effects of exposure of rainbow trout (Salmo gairdneri Richardson) to three sublethal concentrations of zinc (0.248, 0.528 and 1.14 ppm) on delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta HSDH) enzyme activity in the head kidney tissue was investigated. The activity of this enzyme was localized by the reduction of a tetrazolium salt to formazan at the site of activity. Using subjective methods to indicate the degree of activity and indirectly assess the degree of corticosteroid production, the zinc-exposed rainbow trout showed a greater degree of delta 5-3 beta HSDH activity compared to the control fish. This increase in enzyme activity has been associated with the stimulation of the pituitary-interrenal axis by the noxious stress of zinc.

Alcohol Oxidoreductases↗
PubMed1976

The effect of sublethal concentrations of zinc on growth and plasma glucose levels in rainbow trout, Salmo gairdneri (Richardson).

The long term effects of three sublethal concentrations of zinc (0.214, 0.52 and 1.12 ppm) on growth and plasma glucose concentration in yearling rainbow trout Salmo gairdneri (Richardson) were investigated. Analysis of covariance of percent weight increase revealed that a significant inhibition of growth (P less than 0.05) in the 1.12 ppm zinc-exposed fish had occurred. Plasma glucose showed a significant hyperglycemia (P less than 0.05) in all three zinc-exposed groups of fish after 7 days exposure and in the 1.12 ppm zinc-exposed group after 63 days. The hyperglycemia observed has been explained as possibly resulting from activation of the pituitary-interrenal axis by the stress of zinc causing mobilization of tissue glycogen.

Animals↗
PubMed1975

The 1974 Gordon Richards Memorial Lecture: trends in the organization of cancer services.

The development of cancer programs and organizations in Canada is traced from their beginnings until the present time, and tribute is paid to our pioneers, of whom Dr. Richards was an outstanding example in this field. Although provinical cancer control measures vary, there is a marked similarity among some, so that they can be categorized into two or three patterns. The desirable requirements for the establishment and progressive development of cancer centres is described together with their relationship to increasing integration of teaching and research activities. An attempt is made to predict the future pattern of our "cancer clinic" system in which there will be increasing reliance on an interdisciplinary approach.

Canada↗