Biomedical subjects

T A Morsy

Publications and source records attributed to T A Morsy.

At least 19 recordsLinked to original sources

PubMed2005

On the main reservoir host of Fasciola in Dakahlia Governorate, Egypt.

In the present work, a total of 4180 sheep were obtained from different localities at Dakahlia Governorate. One hundred and eighty male sheep were investigated for Fasciola worms (the adult and juvenile forms) at Mansoura governmental abattoir. Four hundred grazing sheep were screened by the coprological examination from ten centers. The mean number of eggs per gm in a group of ten sheep ranged from 2.9-10.8 egg/gm. The number of worms ranged from 5-84. In the Mansoura abattoir, it was found that 37 sheep were infected (20.56%). Fasciola worms were recovered from the livers in 100%, common bile ducts in 60%, gall bladder in 80%, two sites in 50% and three sites in 40% of infected biliary tracts. According to the coprological examination, the infection rate was the highest in El-Manzalla Center (15.75) and the lowest was in Mansoura Center (3.25%). According to the prevalence and egg output results, it is concluded that sheep are the main reservoir host for fascioliasis among the edible animals in Dakahlia Governorate. However, examination of the non-edible animals and the domestic and wild rodents are ongoing and will be published soon elsewhere.

Animals↗

PubMed2004

Diagnostic microarray: an array of possibilities for parasitology.

Parasites affect a majority of the world's population. Despite this fact, dreams of developing vaccines remain far off. Scientists have long studied gene expression as a hallmark of gene activities reflecting current cell conditions. Analyzing differentially expressed genes is a major initiative, and most labs recoil at the amount of time and high costs required obtaining results. By employing microarrays, researchers can decrease their reliance upon time consuming techniques; consequently, microarray is beginning to dominate other molecular diagnostic technologies. Moreover, the ability of microarrays to monitor simultaneous gene expression of thousands of genes and to produce broad arrays of data has the potential to shift the resources of the scientists from data gathering to analyzing data that are already available. As microarray technology improves and its cost decreases, the role of ability to "see" the molecular biology pathways involved in parasite host relationships will place this technology at the forefront of parasite research.

Animals↗

PubMed2001

Ivermectin and clorsulon (ivomec super) in treatment of goats naturally infested with scab mites and biting lice.

Five goats naturally infested with Sarcoptes scabiei, Psoroptes ovis and Bovicola caprae were treated with a combination of ivermectin and clorsulon. A subcutaneous injection in a dose of 1 ml/50 kg live weight was given. This provides dose levels of 200 ug ivermectin and 2 mg clorsulon. Four goats were cured from the three ectoparasites within one to two weeks. The last elder goat, which was anaemic and naturally infected with Trichostrongylus colubriformis, was still infested with the two scab mites, but was free from B. caprae. A postal dose of 0.5 ml/50 kg live weight was given one week later (=3 weeks after the 1st injection). This goat was cured within a week, but still passed some T. colibriformis eggs. The result was discussed.

Animals↗

PubMed2001

Ecto- and blood parasites affecting Meriones rex trapped in Najran, Saudi Arabia.

Meriones rex or king jird is endemic to Arabia, confined to the south-west of the peninsula. Examination of 25 jirds for arthropod-ectoparasites showed Xenopsylla astia, Ctenocephalides arabicus, Ornithonyssus bacoti and tick nymphs with indices of 0.6, 1.6, 0.64 and 0.24 respectively. The ectoparasites were more on female jirds than on males with indices of 3.8 and 2.0 respectively. Indirect haemagglutination tests for anti-Toxoplsama and anti-Leishmania antibodies showed positive reactions in 5 (20.0%) and 2 (8.0%) jirds respectively. However, neither skin lesion nor protozoal parasites were detected in tissue smears of liver and spleen. The ectoparasites encountered and the sero-positive reactions to Toxoplasma and Leishmania denote that the king jird, Meriones rex is of some medical and veterinary importance.

Animal Diseases↗

PubMed2001

Two species of tabanids (order: Diptera) in Aswan District, Egypt.

Tabanus taeniola and Haematopota minuscula were trapped on camels and equines at daytime during summer of 2000. Many species of Tabanus and few species of Haematopota were reported before in Egypt. This paper stresses on the medical and veterinary importance of these vectors.

Animals↗

PubMed2001

A study on Trichomoniasis vaginalis and female infertility.

A total of 280 patients, 240 infertile and 40 pregnant were subjected to thorough history taking, general and local examination for exclusion of organic lesion, laboratory investigations to exclude parasitic, bacterial and fungal infections. Sterile vaginal swab from the posterior fornix was taken, and examined by wet smear preparation, Giemsa staining and cultivation on C.P.L.M. medium for trichomoniasis infection. The mean age of the infertile group was 25.75+/-3.92, and of the control group was 21.6+/-2.38 (in years). The mean duration of infertility was 2.81+/-1.51 (years). Out of 240 infertile women, 18.75% complained of discharge, 17.5% itching, 15.42% dysuria, 14.58% dyspareunia, and 10% had cervical lesion. Of the 40 controls, 5% complained of discharge, 2.5% complained of itching, dysuria, dyspareunia, but none had cervical lesion. Of the total cases (280), 36 (12.9%) had T. vaginalis. The clinical data observed were significantly higher among the infertile group than the control group. Cultures were positive in 14.58% of the infertile group and 2.5% in the control group. The difference between the 2 groups was statistically significant. No doubt, T. vaginalis plays an important role in female infertility.

Adult↗

PubMed2001

Evaluation of soluble adhesion molecules in the diagnosis of amoebiasis, giardiasis and toxoplasmosis.

A total of 47 patients with toxoplasmosis (21 cases) with amoebic liver abscess (14 cases) and with giardiasis (12 cases) as well as 14 healthy control were subjected to thorough history taking, clinical examination, stool & urine analysis, complete blood picture, ESR, C-reactive protein, ASO, widal test, blood cultures, liver function tests, serum creatinine, hepatitis viral markers, rheumatoid factor, auto-antibodies, stool culture, rectal snip, chest X-ray, abdominal sonar, level of serum adhesion molecules (sICAM-1, sELAM-1), ELISA detection of Toxoplasma antibodies in serum, liver biopsy, detection and counting of Giardia cysts. In toxoplasmosis group, highly significant increase in serum levels of sICAM-1 (P<0.01) and significant increase in serum levels of sELAM-1 (P<0.05) in comparison to control. However, only sICAM-1 levels were significantly increased in IgM cases more than in IgG cases. In amoebic liver abscess group, both sICAM-1 and sELAM-1 significantly increased when compared with control. In giardiasis group, highly significant increase of serum levels of sELAM-1 was noticed than in control group (P<0.01), while sICAM-1 showed no significant difference (P>0.05). There was no correlation between sELAM-1 and number of cysts in the stool (intensity of infection). Soluble forms of adhesion molecules especially sICAM-1 have the potentiality as good markers of endothelial damage, severity of disease and to less extend load of infection.

Adolescent↗

PubMed2001

Clinico-epidemiological study of human fascioliasis in an endemic focus in Dakahlia Governorate, Egypt.

Human fascioliasis is increasing in the Nile Delta particularly in Dakahlia Governorate, where it reached 7.47%. In this study, the tetrad of fascioliasis was established as high eosinophilia (100%), fever (85.6%), painful hepatomegaly (81.93%) and anaemia (100%). The laboratory results showed ESR accelerated in 87%, ALT elevated in 21.5%, AST elevated in 21.9%, S. bilirubin elevated in 16.5%, gamma GT elevated in 80.6%, and SAP elevated in 76.4%. Abdominal ultrasonography showed variable findings, as hepatomegaly, splenomegaly, periportal fibrosis, thickened wall of gall bladder, dilated common bile duct, dilated biliary radicals (partial), dilated common bile duct and biliary radicals (total), Fasciola worms in gall bladder, Fasciola worms in common bile duct, stones in gall bladder, stones in bile duct, cystic lesions in the liver, local lesions in the liver and ascitis. The highest was hepatomegaly in 81.93% of fascioliasis patients and the lowest was biliary dilated radicles (partial) in 0.26%.

Abdomen↗

PubMed2001

Soluble adhesion molecules versus lymphoblast transformation in diagnosis of zoonotic cutaneous leishmaniasis.

Twelve parasitologically proven ZCL patients (one with non-ulcerative lesion and eleven with multiple ulcerative lesions) were subjected to estimation of the levels of lymphoblast transformation (LTT) and soluble adhesion molecules (sICAM-1 & sELAM-1 by ELISA). The results proved high percentage of LTT in relation to number and clinical picture of the ZCL lesions. As to the soluble adhesion molecules, sICAM-1 levels were significantly increased than in normal controls and correlated positively with the number of ulcerative lesions. sELAM-1 levels were not significantly increased than the normal controls, but correlated positively with the number of ulcerative lesions. Consequently, soluble adhesion molecules mainly sICAM-1 is a good marker of endothelial damage in ZCL as related to number and clinical type of lesions.

Animals↗

PubMed2001

The pathogenesis of Demodex folliculorum (hair follicular mites) in females with and without rosacea.

In rosacea patients (ages 11-50 years old) 44% were infested with D. folliculorum as compared to normal controls (23.0%). The difference was significant. The mean +/-SD of mite density ranged between 13.2+/-0.9 to 18.2+/-1.2 as compared to normal controls with mite density ranged between 1.4+/-0.25 to 2.4+/-0.3. Demodex infestation in rosacea patients was 66.1% in squamous, 66.7% in erythemato-telangiectate and 83.3% in papulo-pustular rosacea. The highly infested site was check (27.3%) with mean mite density of 25.3+/-1.3, followed by the area around the orbit (23.4%) with a density of 19.0+/-1.2, the area around the nose (19.5%) with mite density of 7.1+/-1.5, then chin (15.6%) with a density of 8.2+/-1.4 and lastly the area around the mouth (14.1%) with a mite density of 14.2+/-1.3. Undoubtedly, infestation with D. folliculorum particularly in large number causes rosacea.

Adolescent↗

PubMed2001

The prevalence of lice infesting students of primary, preparatory and secondary schools in Cairo, Egypt.

Human lice (head and body) are among the arthropod-ectoparasites of worldwide distribution. Examining students in primary, preparatory and secondary schools recorded prevalence rates of 21.86%, 30.38% and 12.94% respectively. The overall rate of the lice infestation in the three schools was 384 out of 1772 or 21.67%. The prevalence rate of lice infestation among males and females were 17.02% & 37.8% (primary school), 27.8% & 33.1% (preparatory school), and 12.0% & 13.9% (secondary school). These totaled 17.7% (males) and 30.26% (females). The overall ratio of head to body lice was 18.2:1. Consequently, lice mainly the head louse, are still a public health problem particularly among female students in the primary and preparatory schools. In the secondary school prevalence rate of the lice infestation was low. So human lice is still a community health problem.

Adolescent↗

PubMed2001

The effect of ivomec super on dogs experimentally infested with Sarcoptes scabiei isolated from a patient.

Scabies infestation is a community health problem worldwide. This is particularly true in overcrowded and unhygienic areas. Seven dogs were experimentally infested with Sarcoptes scabiei freshly recovered from a patient. The dogs after infestation were treated with a mixture of ivermectin and clorsulon (Ivomec Super). The dose given to a single dog was 1 ml/50 kg body weight. This is equivalent to 200 mcg ivermectin and 2 mg clorsulon per Kg body weight. Five of the dogs (71.43%) were completely cured with 1 ml/50 Kg body weight. The remaining two dogs needed each, another injection of the same dose two weeks later. So, ivomec super is effective against the human strain of Sarcoptes scabiei in experementally infested dogs. A general discussion was given.

Animals↗

PubMed2001

Control of Musca domestica third instar larvae by the latex of Calotropis procera (Family: Asclepiadaceae).

Calotropis procera (Family: Asclepiadaceae) is known to contain alkaloids, steroids and resinous substance. Different concentrations of its latex were topically applied to the 3rd stage larvae of Musca domestica. A dose of 3 ul (5% of the latex) killed and partially digested the larvae in three hours. The effect of this latex is most probably enzymatic in nature. No doubt, the shift to plant extracts in controlling insect-vectors or pests in general, pave the way to a health environment.

Animals↗

PubMed2001

Two types of scab mites infesting man and sheep in North Sinai.

Man and sheep were examined for scab mites infestations. Two types of mites were recovered, Sarcoptes scabiei and Psoroptes ovis. In sheep, 197 out of 939 (20.98%) were infested with S. scabiei (4.05%) and P. ovis (16.93%). The highly infested sheep were recorded in El Hassanah (28.22%) and the least infested ones were in Al Arish (15.85%). In man, 69 out of 790 (8.7%) were infested with S. scabiei (8.1%) and P. ovis (0.63%). The highly infested patients were recorded in El Hassanah (16.2%) followed by Rafah (11.7%), Bir Al-Abd (7.8%), and the least infested one was recorded in Al Arish (4.3%). In man, infestation was seen on one site in 15 patients (21.7%), on two sites in 32 patients (46.4%) and on more than two sites in 22 patients (31.9%). The highly infested site was the upper limbs followed by the lower limbs. Infestation on the face and ear, genital organs and abdomen were also encountered. Infestation on two sites was predominant on the upper and lower limbs followed by the lower limbs and genital organ. The results indicate that transmission of both scab mites, S. scabiei and P. ovis from sheep to man do occur. Infestation with scab mites was high in shepherds (79.7%) than in non shepherd patients (20.3%). However, man was more susceptible to S. scabiei than to P. ovis.

Animals↗

PubMed2000

Evaluation of four pediculicides against the head lice Pediculus h. capitis.

Four pediculicides were tested against head lice in-vitro. The LT50 for Licid ranged between 10.75 (at conc. 50%) to 25.08 (at conc. 1%). All lice died with conc. 100% within 5 minutes. With Malathion, the LT50 ranged between 4.23 to 9.3 at conc. 50% to 1% respectively. All lice died with conc. 57% within 3 minutes. With Benzanil, the LT50 ranged between 20.85 to 44.34 at conc. 50% to 1% respectively. All lice died at conc. 2.5% within 10 minutes. With Para plus, the LT50 ranged between 18.46 to 29.5 at conc. 100% to 50% respectively. All lice died with conc. 100% within 30 minutes. So, the least time needed to kill all lice was given with Malathion (3 minutes). The least dose of pediculicide needed to kill all lice was those of Benzanil (1% = 0.025) and Malathion (1% = 0.57). The whole results were discussed regarding the advantages and disadvantages of these pediculicides.

Animals↗

PubMed2000

Chironomid potent allergens causing respiratory allergy in children.

Generally speaking, chironomids contain potent inhalant allergens. The skin prick tests with chironomid crude extract (Chironomus (C.) calipterus) were positive in 20 out of 25 children with respiratory allergy. The skin prick tests with house dust mite crude extract (Dermatophagoides pteronyssinus) were positive in 3 of these 20 chironomoid positive skin tests. Chironomid-specific IgE-ELISA were demonstrated in the sera of 17 (85%) of the chironomid skin positive patients. These 17 patients gave negative skin prick test to house dust mite crude extract. It is concluded that chironomid allergens should be considered when dealing with human respiratory allergy caused by arthropods.

Adolescent↗

PubMed2000

Effect of ivermectin on the brown dog tick, Rhipicephalus sanguineus.

Ivermectin (Ivomec) proved to be effective in controlling R. sanguineus. All brown dog ticks infesting the treated dogs (subcutaneous injections) with 1.5 ml or 2 ml/50 kg dropped off within 4 or 3 days respectively. The dropped off ticks were completely inactive and died within one day or two. Ticks exposed to filter papers impregnated with 100 micrograms/ml (66.67%) died within four days. A dose of 1.5-2 microliters/50 kg eradicated Toxocara canis infection in four dogs, and caused shrinkage of Dipylidium caninum gravid segments in three. A general discussion was given with special reference to the contraindications and side effects of ivermectin particularly for human usage.

Animals↗

PubMed2000

Epidermal growth factor in patients with schistosomal and/or viral liver diseases and portal hypertension.

A large number of growth factors have been described and their action and interaction is proving to be complex. The presence study estimated the epidermal growth factor (EGF) in portal hypertension patients with chronic liver disease due to bilharziasis or viral infection as well as in patients with peptic ulcers. The results showed different statistical values regarding liver cirrhosis, oesophageal varices, and bleeding. No doubt, the EGF was indirectly stimulated by the schistosomal and/or viral infection.

Epidermal Growth Factor↗