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Biomedical subjects

T A Mackenzie

Publications and source records attributed to T A Mackenzie.

4 recordsLinked to original sources

Comparing in-patient classification systems: a problem of non-nested regression models.

Since 1983, hospitals in the United States have been receiving prospective payment for their in-hospital patient admissions covered under Medicare. Under such schemes each patient is placed in a group by a classification system, known as the Diagnosis Related Groups (DRG), and the hospital is reimbursed by the Health Care Financing Administration according to some predetermined group average, adjusted for hospital level characteristics, such as size, location and teaching activity. Recent interest has focused on refining the DRG system or considering totally different systems of classification. Studies designed to compare the ability of different systems to account for between-patient variability in resource consumption in the same dataset lead to the problem of model selection between large non-nested regressions, where resource consumption, measured by length of hospital stay or costs, is regressed on dummy-indicator variables representing different patient groups. We use a simple measure of fit to develop a symmetric test of the null hypothesis that the two systems account equally well for variability in resource consumption. With this method, unlike methods such as Akaike's AIC criterion, we can quantify the probability of a false positive, and thereby limit the probability of choosing one system over another when it is no better at accounting for variability in resource consumption.

Diagnosis-Related Groups

Hemodialysis. Basic principles and practice.

Hemodialysis removes uremic toxins and excess fluid from the blood by diffusion dialysis and ultrafiltration. The efficiency of this process depends on the size, shape, and type of semipermeable membrane used in the hemodialyzer. Although the hollow-fiber kidney remains popular, the parallel-plate hemodialyzer is reestablishing itself, partly because it can use newer types of membranes. With newer membranes, ultrafiltration can be performed without diffusion dialysis, which appears to have important clinical advantages. The dialysate bath used in the hemodialyzer resembles plasma water in composition, with electrolytes added to compensate for abnormalities of end-stage renal disease. Although the technical problems of hemodialysis have been largely overcome, an accurate, easy-to-use method of evaluating the adequacy of the hemodialysis prescription has yet to be devised.

Acute Kidney Injury

A simple method for estimating nitrogen balance in hospitalized patients: a review and supporting data for a previously proposed technique.

Total urinary nitrogen (TUN) and urinary urea nitrogen (UUN) in a 24-hour urine collection were measured under a variety of clinical and nutritional conditions in 81 patients for 564 study days. The difference between TUN and UUN averaged 1.8 +/- 0.9 g/day (range 0.0-5.8 g/day) and was independent of the absolute value for UUN. Since UUN was found to correlate linearly with TUN (R = 0.98) over a wide range of values, it is possible to estimate an approximate TUN excretion by adding a constant to the nitrogen excreted as urea. On the basis of the measured mean difference, we suggest using an estimate of 2 g of nitrogen per day. We feel this will not seriously under- or overestimate urinary nitrogen excretion in the calculation of nitrogen balance for the clinical management of nutritional support therapies. Since all hospitals can perform this routine test, it provides an effective, simple, and rapid method to follow accurately the protein catabolic response during disease and response to nutritional therapy. This method, without the supporting data presented here, has previously been recommended [Blackburn et al, 1977, JPEN 1:11-22] and has become a widely used technique for nutritional assessment.

Hospitalization