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Biomedical subjects

T A Junaid

Publications and source records attributed to T A Junaid.

At least 37 records · Page 2Linked to original sources
PubMed1983

Acquired tricuspid incompetence in children: pitfalls in the clinical diagnosis of its aetiology.

Pitfalls in the clinical diagnosis of the aetiology of acquired tricuspid incompetence in children were exemplified in five patients. In three of them acute staphylococcal endocarditis, the cause of the valve defect, was obscured during life by co-existing sickle cell haemoglobinopathy, acute leukaemia and rheumatic mitral valvulitis, respectively. The fourth and fifth patients had clinical features suggestive of right ventricular endomyocardial fibrosis but necropsy revealed that the tricuspid incompetence was caused by dilated cardiomyopathy and constrictive pericarditis respectively. This series illustrates the need to suspect bacterial endocarditis if a child presents with signs of infection and valvular incompetence, and also dispels the widespread belief that pericardial constriction does not cause tricuspid incompetence.

Cardiomyopathies↗
PubMed1982

Hepatic resection in primary liver carcinoma: prolonged survival in two Nigerian patients.

Two Nigerian patients with primary liver carcinoma (PLC) who had wedge resection with prolonged survival are described. The localization of their tumors to the right hepatic lobe and their polypoidal nature were favorable factors that allowed early detection and treatment.The surgical treatment of PLC is reviewed. It is suggested that suitable African patients with PLC be offered resection as a modality of treatment coupled with adequate follow-up to detect and deal with recurrence early.

Adult↗
PubMed1981

Ovarian neoplasms in children and adolescents in Ibadan, Nigeria.

Ovarian tumors diagnosed at the University College Hospital (UCH), Ibadan, Nigeria, in 169 patients less than 20 years of age have been analyzed. The most common tumor involving the ovaries of Nigerian children was Burkitt's lymphoma, which was bilateral in all cases. Germ cell tumors accounted for 67.1% of 76 non-Burkitt's tumors, while tumors of the sex cord stroma were encountered more frequently than epithelial tumors. Epithelial tumors were less frequently diagnosed than in previously reported series, and none was found in 122 patients under 14 years of age. It is suggested that Burkitt's lymphoma may primarily affect the ovaries and that the low frequency of epithelial tumors in Africans may be related to genetic differences in the metabolism of the female sex hormones.

Adolescent↗
PubMed1980

Cytologic diagnosis of ascitic fluid in Ibadan, Nigeria.

Malignant cells were detected in 24.2 percent of 859 ascitic fluid aspirates examined in the Department of Pathology, University College Hospital, Ibadan, Nigeria. Burkitt lymphoma cells accounted for over one half (52.9 percent) of the malignant cells. Cancer cells were also detected in primary liver cell carcinoma, ovarian cancer, and gastrointestinal cancer in decreasing order of frequency. Exfoliative cytology is useful in the differential diagnosis of ascites.

Ascitic Fluid↗
PubMed1979

Chondrosarcoma of the jaws in Ibadan, Nigeria--a report of four cases.

Four cases of chondrosarcoma of the jaws seen in our clinics within a period of 15 years are described. In all, the lesions were initially benign-looking making early diagnosis difficult. The histogenesis of chondrosarcoma of the jaws is briefly discussed. In our environment, the prognosis of this disease is very poor.

Adult↗
PubMed1979

Perigenital cutaneous schistosomiasis.

Perigenital cutaneous schistosomiasis was diagnosed in a patient who had no previous genitourinary or gastrointestinal symptoms suggesting schistosomiasis; his only symptom was a pruritic papular rash in the perineum. Late cutaneous schistosomiasis due to deposition of ova in the dermis is rare but can affect the genital and periumbilical areas. This report highlights the difficulty in diagnosing cutaneous schistosomiasis and the need for biopsy of itchy cutaneous lesions in patients from localities where the infection is endemic.

Child↗
PubMed1979

Mortality in middle-aged Nigerians: an autopsy study.

Analysis of a 5-year autopsy data on Nigerians aged 31--60 years showed infective, cardiac and neoplastic diseases as major causes of mortality in these age groups. Improvement in public health and socio-economic circumstances, and preservation of cultural dietary habits would prevent a large proportion of deaths and a rise in degenerative diseases.

Adult↗
PubMed1978

Prognostic value of histological grading of hydatidiform moles.

Histological study of materials from 282 patients with hydratidiform moles showed no correlation between the degree of trophoblastic proliferation and the subsequent development of choriocarcinoma. A significant number of invasive moles, however, showed a marked degree of trophoblastic proliferation. All patients with molar pregnancy should continue to have adequate and mandatory clinical follow-up.

Female↗
PubMed1978

Clinicopathological appraisal of Brenner tumours of the ovary in Ibadan.

A review of the clinical and pathological features of 31 cases of Brenner tumour of the ovary showed a higher frequency in the postmenopausal age group and larger number of bilateral tumours (13%) than reported hitherto. Most cases of the tumour were incidental findings; cystadenoma of the ovary and uterine leiomyomata were the most frequent lesions with which the Brenner tumours were associated. None of the cases of Brenner tumour was malignant. Presumed hormonal activity could not be morphologically correlated with any of the tumours.

Adult↗
PubMed1978

Histopathological studies of carcinoma of cervix uteri in Ibadan.

Carcinoma of the cervix is by far the commonest gynecologic malignancy in Ibadan. In a histopathologic study of the disease, 93.9% of all the cases were found to be of the squamous cell carcinoma variety while 6.1% were of the adenocarcinoma group. It was found that most patients with the well differentiated squamous cell carcinoma were above the age of 45 years in contrast to the undifferentiated carcinoma. Even though the difference was not statistically significant, it was speculated that cervical cancer manifesting itself before the age of 45 years may be more aggressive than that occurring in older women. Similarly, it was shown that increasing age, more frequent marriages and parity may augment the possibilities, at least in the negro population, of a woman developing adenocarcinoma of the cervix.

Adenocarcinoma↗
PubMed1976

Choriocarcinoma in Ibadan: clinicopathologic studies.

The host tissue reaction to choriocarcinoma was studied in 81 Nigerian patients. A mononuclear cellular reaction, observed in about 42 per cent of the patients, was composed mainly of lymphocytes, plasma cells, histiocytes, and eosinophils in varying quantities around tumor deposits. No correlation was found between the survival of the patients and the intensity of the cellular reaction. Late presentation by our patients for medical advice and treatment may partly account for the relatively poor response to chemotherapy. The syncytiotrophoblast appears to play a primary role in vascular invasion by the neoplastic trophoblast.

Choriocarcinoma↗