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Biomedical subjects

T A Gus'kova

Publications and source records attributed to T A Gus'kova.

At least 19 recordsLinked to original sources
PubMed2005

[Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].

AIM: To study antiviral activity of arbidol in relation to various antigenic subtypes of influenza virus isolated from humans; efficacy of arbidol action in combination with adamantanic antiviral drugs, ribavirin and ribamidil on reproduction of influenza virus A (IVA) in cell culture. MATERIAL AND METHODS: The activity of the drugs against viral reproduction was assessed by inhibition of viral antigens expression detected in virus-infected cells using enzyme immunoassay (EIA). RESULTS: Arbidol is not inferior to adamantanic drugs, neuraminidase inhibitors, ribavirin and ribamidil by its inhibiting activity in relation to influenza viruses A and B. Arbidol inhibits reproduction of human IVA antigenic strains H1N1, H2N2, H3N2 and remantadin-sensitive and remantadin-resistant strains of influenza virus. Arbidol inhibits reproduction of pathogenic for humans strains of avian influenza virus H5N1 and H9N2, strains H6N1 and H9N2 having internal genes common with H5N1 and H9N2. The inhibiting activity of arbidolin on cell culture viral reproduction enhanced if arbidol was used in combination with amantadine, remantadin, ribavirin and ribamidil. CONCLUSION: Arbidol has a wide spectrum antiviral activity and inhibits reproduction of various antigenic subtypes and remantadin-resistent human IVA, avian viruses H5N1 and H9N2, influenza viruses B and C.

Amantadine↗
PubMed1999

[Mechanisms of arbidole's immunomodulating action].

The immunomodulating activity of arbidole was studied in cultured cells, animals, and human beings. Arbidole was shown to have effects on nonspecific defense factors, on its capacity to induce interferon and activate phagocytes in particular. Arbidole-treated patients with lower baseline immunity showed improvement in immunological parameters (in the counts of CD4 and CD8 lymphocytes, B lymphocytes, in the levels of serum immunoglobulins). Arbidol produces a high preventive and therapeutical effects in influenza A and B and other acute respiratory viral infections, prevents postinfluenza complications, reduces the incidence of exacerbations of chronic diseases in postinfluenza patients. In influenza, the therapeutical efficiency of the drug appears as decreases in intoxication, the severity of catarrhal syndrome, shorter fever and disease in general. Arbidole is beneficial for patients with second immunodeficiency, in those with recurrent herpes infection or chronic bronchitis. After arbidole treatment regimen, postoperative immunological parameters became normal in cardiac surgical patients, which suggests that the drug should be used in cardiac surgical care. The agent showed no side effects in any case.

Animals↗
PubMed1987

[Slow elimination of a prazosin metabolite compared to prazosin kinetics after its intravenous administration to rabbits].

Serum concentration profiles of prazosin and its metabolite 2-(1-piperazinyl)-4-amine-6,7-dimethoxyquinazoline after intravenous bolus administration to rabbits (0.5 mg/kg) were shown to be biphasic. Rapid decline related to distribution was followed by a terminal slope lasting for up to 24 hours. Prazosin level in this phase decreased, its elimination half-life being about 9 hours, while the metabolite serum level was almost constant between 4 and 24 hours and averaged 0.9 mumol/l. This is in keeping with the earlier suggested extremely low elimination rate of this metabolite. Enterohepatic recirculation may account for this phenomenon, as well as a significant rise in the metabolite serum concentration I hour after the injection.

Animals↗
PubMed1984

[Identification of N,N-dimethyl-O-(beta-D-glucopyranuronosyl)-5- hydroxytryptamine as a bufotenine metabolite in the rabbit].

A bufotenine metabolite has been isolated from the rabbit urine by the column chromatography on cellulose and preparative paper electrophoresis in acidic buffer. It has the structure of N,N-dimethyl-O-(beta-D-glucopyranuronosyl)-5-hydroxytryptamine as proved by comparison of chromatographic, electrophoretic and NMR data with those for respective synthetic O-glucuronide.

Animals↗
PubMedDate not supplied

[Antioxidant properties of arbidol and its structural analogs].

The effect of arbidol and its structural analogues on the process of lipid peroxidation in phospholipid liposomes induced by Fe2+ has been investigated. It was shown that the antioxidant efficacy of arbidol and its derivatives is lower than that of alpha-tocopherol by two or three times. It was suggested that the mechanism antioxidant action of the arbidol and its structural analogues consists of scavenging of lipid radicals rather than chelating of Fe2+.

Antioxidants↗
PubMedDate not supplied

[Study of the effect of antiviral drugs on the reproduction of the respiratory syncytial virus by enzyme immunoassay].

A test system based on EIA was developed for evaluating the efficiency of drugs active towards the respiratory syncytial virus (RSV) in cell culture. Virasole and its structural analog ribamedii active towards RSV infection and arbidol whose activity in RSV infection is unknown were tested. Like virasole and ribamedil, arbidol inhibited the expression of RSV antigens, the inhibitory effect increasing with the drug concentration and decreased with increase of the multiplicity of virus infection. MIC50 for arbidol, virasole, and ribamedil were 10, 5, and 6 micrograms/ml, respectively. These data prompt clinical trials of arbidol in RSV infection.

Antiviral Agents↗
PubMedDate not supplied

[Distribution of prazosin and its metabolites in animal organs during chronic administration].

The distribution of prazosin and its metabolites in organs of rabbits and rats during oral long-term administration at different doses was studied. Prazosin was shown to be accumulated in the animals' organs. Three metabolites of prazosin one of which was identified were detected in the blood serum, bile and organs of the animals. The contents of prazosin and the metabolites in organs and tissues were non-linearly related to the dose.

Adrenal Glands↗
PubMedDate not supplied

[Inhibiting effect of dioxidine on corticosteroid secretion in an experiment].

The determination of corticosterone and aldosterone levels in the peripheral blood of rats and a cortisol level in the blood of guinea pigs by a radioimmunoassay following the administration of dioxydin (1,4-N-oxide 2 2,3-dioxymethylquinoxaline) has shown that it produces an inhibiting effect upon the secretion of corticosteroid hormones in animals with a diverse direction of their biosynthesis. There is a dose dependence of the effect detected. Substitution therapy with corticosteroids cuts short adrenal insufficiency caused by dioxydin.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Tolerance for nonsteroidal anti-inflammatory agents by experimental animals during pregnancy].

The authors studied the tolerance of three nonsteroidal anti-inflammatory drugs, voltaren, indomethacin and ibuprofen by rats at different times of pregnancy and compared voltaren tolerance by pregnant and nonpregnant females. It was shown that as compared to nonpregnant animals, pregnant animals tolerated voltaren more poorly. The tolerance of both voltaren and indomethacin was particularly poor in the last trimester of pregnancy. The enhancement of the drug toxicity during pregnancy because of the changes in body function is discussed.

Animals↗
PubMedDate not supplied

[Circadian fluctuations in dioxidine toxicity].

It has been established in rat experiments that toxicity of the antibacterial drug dioxydin (1,4-di-N-oxide 2,3-dioxymethylquinoxaline) depends on the time of administration. The drug exhibits the minimal and maximal toxicity upon administration at 8 o'clock p.m. and at 12 o'clock, respectively.

Administration, Oral↗
PubMedDate not supplied

[Toxicological study of the Soviet tetracyclic antidepressant inkazan].

The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.

Animals↗
PubMedDate not supplied

[Effect of phenobarbital, hexamidine and benzonal on the toxicity of dioxidine].

It has been shown in experiments on rats that phenobarbital, hexamidine and benzonal administered in doses producing the induction of liver microsomal enzymes reduce the total toxic action of dioxydin and pathological alterations in the adrenals induced by dioxydin. A possible mechanism of the effect under consideration is discussed.

Adrenal Glands↗