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Biomedical subjects

T A Glavinskaia

Publications and source records attributed to T A Glavinskaia.

At least 19 recordsLinked to original sources
PubMed1990

[New approaches to characterizing the immune status of patients with lupus erythematosus using immunoenzyme testing].

A total of 78 patients with various forms of lupus erythematosus (LE) were examined with the use of enzyme immunoassay (EIA) to test the possibility of antibody production in response to neuraminidase, an antigenic stimulant. Positive EIA results were recorded in 54.5% of patients with the integument LE forms and in 58.3% of those with systemic LE. The intensity of antibody production depended on the patients' sex (it was more active in females), age, and the disease duration. In the course of therapy negative results replace positive ones mostly in the patients with a disease of not long standing. A correlation was revealed between the content of circulating immune complexes measured by polyethylene glycol sedimentation and the levels of IgM and IgG. The detected relationship between the level of antineuraminidase antibodies and features of the disease course and therapy, agreement of this parameter with other immunologic characteristics, availability and informative value of the method recommend it for the assessment of immunity disorders in LE patients.

Adolescent↗
PubMed1990

[Lysozyme in the combined therapy of erythematosis].

Lysozyme was administered to 57 patients with lupus erythematosus (LE) for 10 days according to 4 schemes: Group 1 (n = 10)--30 mg of lysozyme 3 times a day sublingually; Group 2 (n = 10)--100 mg daily i.m.; Group 3 (n = 10)--100 mg twice a day i.m.; Group 4 (n = 27)--100 mg 3 times a day i.m. After a course of lysozyme therapy patients with discoid and disseminated LE were prescribed delagil, those with systemic LE were administered corticosteroid hormones in moderate doses or presocyl. The treatment was well tolerated, only 2 (3.5%) patients developed toxicoderma. The results evidence that lysozyme efficacy is not inferior to that of levamisole but this agent is better tolerated. Clinical and paraclinical efficacy was higher in Groups 1 and 4; cellular, humoral, and local immunity parameters, as well as the characteristics reflecting the inflammatory processes evidence positive changes developing as a result of lysozyme therapy, these changes persisting in the majority of cases during further combined treatment. Therapy with low doses of lysozyme is indicated for patients with the immune status disorders mainly. If changes in the nonspecific resistance predominate, the scheme used in Group 4 is advisable.

Adult↗
PubMed1989

[HLA and ceruloplasmin phenotypes in lupus erythematosus and circumscribed scleroderma].

The incidence rates of combinations of A and B loci histocompatibility antigens in loci and haplotypes and of ceruloplasmin phenotypes have been examined in 137 patients with lupus erythematosus (LE) and scleroderma circumscriptum (SC). The studies have revealed that LE and SC are associated with certain haplotypes and HLA antigens combinations, this indicating the contribution of these phenotypes to the realization of the genetic predisposition to these diseases. In A1B8 haplotype carriers the disease is characterized by a benign course and manifests by integument forms of LE and scleroderma. IN A2B8 haplotype carriers the disease is more grave and presents as the systemic variant of LE. The third type of ceruloplasmin not detectable in normal subjects is usually associated with A9B18, A25B18, A3B27 haplotypes and with HLA A3A9 antigenic combination mostly in LE patients.

Adolescent↗
PubMed1989

[The immune status of scleroderma patients undergoing electroacupuncture].

Examinations of the immune status of 53 patients with local scleroderma (LS) have revealed changes in the cell-mediated (a deficit of T-lymphocyte population in the presence of an unchanged B-lymphocyte count) and humoral immunity (hyperproduction of the circulating immune complexes, of immunoglobulins A and M, the presence of antibodies to fixed lymphocytes). The patients have been treated by electroacupuncture according to an original method, effecting the points that stimulate suppressed immunity. 1-3 courses of treatment have yielded good results in 83% of the patients, mostly with the early stages of the disease. The treatment has been associated with a positive time course of a number of disturbed parameters of immune homeostasis; a correlation between the clinical and immunological efficacy of therapy has been noted.

Acupuncture Therapy↗
PubMed1989

[A case report of extragenital hard chancres].

The author describes two cases of extragenital location of hard chancres that has prevented a timely diagnosis of syphilis. The diagnostic errors have been due to inadequate competence of the physicians, not making use of laboratory methods of diagnosis.

Adult↗