Biomedical subjects
T A Connors
Publications and source records attributed to T A Connors.
Antibody-directed enzyme prodrug therapy.
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An athymic nude mutation in the rat.
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In vivo studies with hexamethylmelamine.
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In vitro studies with hexamethylmelamine.
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Preparation and antitumor activity of 1-aryl-3,3-dimethyltriazene derivatives.
Several 1-aryl-3,3-dimethyltriazene derivatives have been synthesized and tested for their antitumor activity against the TLX5 lymphoma in mice. These compounds are characterized by the presence of a carbonyl group bound to the benzene nucleus in the para position to the triazene funciton. Three p-sulfamoyl derivatives have also been included and proved to be inactive. Among the carbonyl derivatives compounds 1 and 20, which can be used as reference, cause ILS of about 50%, respectively, at four and three dose levels. Compound 16, the o-nitro-phenylhydrazone of the hydrazide 1, is active at all six dose levels studied. The adduct 19, obtained from the same hydrazide and p-nitrobenzaldehyde, is active at four dose levels, and the ILS values at two optimum doses are significantly greater than those caused by compound 1.
Regression of human lung tumor xenografts induced by water-soluble analogs of hexamethylmelamine.
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Tumour inhibitory triazenes: structural requirements for an active metabolite.
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Commentary: screening for anti-cancer agents; the relative merits of in vitro and in vovo techniques.
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Letter: Cysteine and survival of transplanted thymoma.
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Studies of the mechanism of action of the tumour-inhibitory nitrosoureas.
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Drugs used in the treatment of cancer.
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The metabolism of the anti-tumour agent 1(1-aziridinyl)- 2,4-dinitrobenzene (CB 1837).
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Structure and activity relationships of platinum complexes with anti-tumour activity.
A number of complexes of platinum(II) and platinum(IV) have been prepared, characterised and tested for their ability to cause regression of a mouse plasma cell tumour. All active compounds possess two cis amine ligands but the oxidation state of the platinum is not critical. Relatively minor structural and substituent changes in the amine can lead to major and dramatic changes in the therapeutic index, generally, but not necessarily, associated with changes in toxicity. Some preliminary results on the relationship between structure and solubility are also reported.
Cytotoxic sulphonamides designed for selective deposition in malignant tissue.
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Proceedings: Mechanism of action of tumour inhibitory nitrosoureas.
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