Persistent drug-induced parkinsonism.
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Biomedical subjects
Publications and source records attributed to T A Aronson.
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Considerable confusion and disagreement remains in the psychiatric literature over the meaning of the term borderline. Over the last ten years a veritable explosion of books and articles on the subject have espoused overlapping and at times contradictory ideas on entirely different levels of discourse: biological, genetic, pharmacological, objective-descriptive, ego psychology theory, object relations theory, separation-individuation theory, and so on. Together, they seem both bewildering and irreconcilable. Despite DSM III's efforts to impose conceptual clarity, the situation remains a semantic mess. "Borderline" still means different things to different people and still tends to be a wastebasket diagnosis. No definition has been entirely satisfactory. This article is a preliminary effort at synthesis and explication of how and why psychiatry has arrived at this state of affairs.
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Two patients with panic disorder received therapeutic doses of antidepressants. They developed endogenomorphic symptoms of major depression according to DSM-III-R criteria despite remission of their panic attacks. Treatment-emergent depression in panic disorder has been previously associated with high potency benzodiazepines. Whether antidepressant medications may unmask a depressive diathesis or are coincidentally associated with depression is discussed in this report.
This retrospective study examined 75 outpatients who received an atypical anxiety disorder diagnosis in a 30-month period. Patients who were later rediagnosed tended to have multiple anxiety diagnoses. "Atypical," in this sense, meant that insufficient information was available to arrive at specific anxiety diagnoses. A subgroup that continued to be diagnosed as atypical throughout their treatment tended to have multiple subsyndromal complaints, unusual symptoms, or both. This subgroup raises questions regarding the cutoff criteria for the anxiety disorders in DSM-III and DSM-III-R and suggests a possible new diagnostic subtype for future investigation.
Forty patients from an outpatient lithium clinic were studied who had a clear history of organic abnormalities which predated their affective symptomatology. In the course of reviewing the clinical histories regarding these patients, it was observed that only 37.5% of the patients had ever received a clinical diagnosis of organic affective syndrome. Variables associated with a failure to consider a diagnosis of organic affective syndrome were investigated.
Researchers studying cognition in mania have assumed that mania is a homogeneous entity. Recent preliminary evidence indicates that some manic syndromes may be preceded by medical, pharmacological, and neurologic antecedents. While DSM-III suggests that mild cognitive impairment may be associated with these manic syndromes, studies to date have not documented this assertion. We compared bipolar patients with antecedent neurologic factors (neurologic manics, NM) to bipolar patients without such histories (primary manics, PM) on standard neuropsychological measures and clinical parameters to ascertain whether cognitive testing could be used as an adjunctive diagnostic tool in defining this subgroup of patients. Results indicated that the NM group was more dysfunctional in intellectual functioning and course of psychiatric illness than the PM group.
An analysis of the phenomenology and treatment course of 52 subjects with delusional depression suggests that there may be various subtypes: bipolar, early-onset unipolar and possibly a late-onset unipolar. The bipolar subgroup tended to relapse in different but always psychotic directions, and was resistant to lithium carbonate treatment alone. Treatment refractoriness, delusional depressive recurrences, and a dementia-like presentation were associated with a small late-onset subgroup. A high rate of delusionally depressive relapses also characterized the early-onset unipolar group, however, patients with single episodes were found only in this subgroup.