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PubMed2005

RALGA (Diacneal) decreases melanin content in a human skin model.

BACKGROUND: Retinaldehyde and glycolic acid RALGA (Diacneal) are both effective in the topical treatment of acne. A decrease in the postinflammatory pigmentation has been observed after application of Diacneal during 3 months. AIM: To verify the effect of this association on pigmentation using an original model of surviving human skin. METHODS: Human skin explants were maintained alive in organ culture for 14 days. Diacneal was applied every day. Pigmentation of skin, depending on the transfer of melanosomes from melanocytes to keratinocytes, was visualized histologically by Fontana-Masson staining. The number of melanocytes was determined after the DOPA reaction. RESULTS: A decrease in melanin content was shown after application of Diacneal. The number of melanocytes was not modified. CONCLUSION: These results suggest that RALGA (Diacneal) may be of interest to prevent the postinflammatory pigmentation of acne.

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PubMed2002

[Cheilitis].

Cheilitis is clinically characterised by an acute or chronic inflammatory state of the lips, limited to the vermillion border. The term "angular" cheilitis applies to localise bilateral lesions of the angles of the mouth. Acute cheilitis is erythematous or erosive, accompanied by a stinging sensation. Chronic cheilitis is for the most part erythemato-squamous, and is often asymptomatic. The classification of cheilitis is based on the aetiology, being most often an allergy, an infection or a physical irritation, potentially favourised by particular anatomical conditions. However, the distinction between the diverse types is sometimes blurred as diverse causes can co-exist.

Cheilitis↗