Biomedical subjects

Svjetlana Radovic

Publications and source records attributed to Svjetlana Radovic.

3 recordsLinked to original sources

PubMed2006

Immunohistochemical evaluation of the HER-2 protein in the infiltrative lobular breast cancer.

AIM OF THE STUDY: To investigate the correlation between the expression of HER-2 membrane protein and basic pathohistological parameters in cases of infiltrative breast cancer. MATERIAL AND METHODS: Sixty-nine cases of lobular infiltrative breast cancer were investigated. Mastectomy with a dissection of axillary's lymph nodes was performed in all cases. Upon standard procedure of formalin fixation, embedding in paraffin and examination of slides stained with hematoxillin-eosin, a semiquantitaive method of evaluation of immunohistochemical expression of the HER-2 protein has been performed in all tissue samples of the tumor. RESULTS: Majority of patients (91,3 %) were above 41 year-of-age. In the majority of cases (44,9 %) cancer's diameter ranged from 20-50 mm (pT2), with a moderate degree of differentiation (46,4 %), no signs of vascular invasion (50,7 %) and no metastases in axillary's lymph nodes (65,2 %). Evaluation of immunohistochemical expression of the HER-2 protein revealed that only the degree of tumor differentiation has been in statistically significant (p=0, 037) correlation with the intensity of the HER-2 protein expression. CONCLUSION: In cases of lobular infiltrative breast cancer, oncogenic effect of the HER-2 protein was associated with the degree of cellular differentiation, while it was not in correlation with other pathological parameters of poorer prognosis, such as the size of tumor, presence of vascular invasion and occurrence of metastases in regional lymph nodes.

Adult↗

PubMed2005

Vineyard pesticide induced changes in the lungs: experimental studying on rabbits.

Our intention was to analyze changes in the lungs in rabbits induced by the inhalation of the Bordeaux Mixture aerosol and determination of the time necessary for development of changes that cause respiratory failure and eventually precancerous changes. To experimental rabbits aerosol was administred for 4 months. Lungs were examined pathohistologically and histochemically with rubeanic acid for copper detection. After 4 months of everyday inhalation lung tissue showed diffuse inflammation in all experimental animals, but without granulome formation and fibrosis. The bronchial epithelia showed basal hyperplasia and ciliocytophtoria without precancerous atypical squamous metaplasia. The development of centrilobular emphysema was also observed. Numerous macrophages within the lumen of bronchi, in the interstitium as well as those within the lung alveoli, contain granules with a positive reaction on copper. A four-month-period is not enough for inducing interstitial fibrosis or granuloma foration within the lung tissue, what some authors have found in experimental animals during their longer exposure in relation to humans, as well as in vineyard sprayers during their longer exposure at work, where cytologically can be found unusual mataplastic bronchi cells. At least a six-month period of exposure influenced by Bordeaux Mixture is thought to be the minimal period needed for development of changes in the lung tissue which can cause "Respiratory Failure" as well as unplastic expansion.

Administration, Inhalation↗

PubMed2002

[Colorectal polyps].

The polyp is a focal mass that projects from the wall into the lumen. The term polyp is appropriate for gross, radiologic, and endoscopic usage and should be further modified to indicate topographic site, size, number and shape. Strictly spoken, a polyp consists of a head and a stalk, but also the lesions without a clear stalk, but still protruding into the lumen, are called (sessile) polyps. In this view, "polyp" means any lesion, which is circumscribed and raised above normal surrounding mucous membrane so that it is visible to the naked eye. Clinicians sometimes even use "polyp" to refer to any tumor detected in the large intestine. The term polyp does not hold any information about the pathological nature of the lesions. Some polyps (benign, non-neoplastic polyps) do not have an increased potential for becoming malignant, while other polyps (adenomas, neoplastic polyps) are precancerous, which may progress to malignant lesions (carcinomas). Thus polyps must be biopsied or resected to determine their histological type and establish a complete diagnosis.

Colonic Neoplasms↗