Biomedical subjects

Suzanne P McKee

Publications and source records attributed to Suzanne P McKee.

18 recordsLinked to original sources

PubMed2006

Visual information throughout a reach determines endpoint precision.

People make rapid, goal-directed movements to interact with their environment. Because these movements have consequences, it is important to be able to control them with a high level of precision and accuracy. Our hypothesis is that vision guides rapid hand movements, thereby enhancing their accuracy and precision. To test this idea, we asked observers to point to a briefly presented target (110 ms). We measured the impact of visual information on endpoint precision by using a shutter to close off view of the hand 50, 110 and 250 ms into the reach. We found that precision was degraded if the view of the hand was restricted at any time during the reach, despite the fact that the target disappeared long before the reach was completed. We therefore conclude that vision keeps the hand on the planned trajectory. We then investigated the effects of a perturbation of target position during the reach. For these experiments, the target remained visible until the reach was completed. The target position was shifted at 110, 180 or 250 ms into the reach. Early shifts in target position were easily compensated for, but late shifts led to a shift in the mean position of the endpoints; observers pointed to the center of the two locations, as a kind of best bet on the position of the target. Visual information is used to guide the hand throughout a reach and has a significant impact on endpoint precision.

Arm↗

PubMed2006

Initial visual information determines endpoint precision for rapid pointing.

We investigated how visual noise in the initial estimate of target location affects precision for rapid pointing. Visual localization thresholds (an error measure) rise systematically with eccentricity, doubling at eccentricities of a degree or less. Previous work, which we confirmed, has shown that the precision of pointing, measured by the standard deviation, to a single isolated target is relatively constant over small lateral extents near the midline, and that pointing error is substantially larger than visual error. We used target uncertainty (randomly chosen locations) to greatly increase visual noise so that we could explore the influence of visual noise on pointing error. We compared precision for comparable visual and pointing tasks as a function of target eccentricity. The target was presented for 110 ms at one of eight isoeccentric locations, chosen at random. Under these conditions, pointing error increased significantly with increasing target eccentricity. Beyond 4 degrees eccentricity, visual thresholds and pointing error were identical. Even when the target remained visible until the movement was completed, initial target eccentricity affected pointing error. The quality of visual information varies with task demands, and therefore so does its influence on endpoint precision. Our results demonstrate that the initial visual information about target location can limit endpoint precision, even over as small a range as 12 degrees in the central visual field (a lateral extent of +/-8.5 cm at the midline).

Fingers↗

PubMed2006

The effect of spatial configuration on surround suppression of contrast sensitivity.

Contrast sensitivity is known to be strongly influenced by the target surround, yet the role of the surround interaction in visual processing remains unclear. Previously, we have shown that the surround strongly suppresses contrast sensitivity in the periphery when the surround spatial frequency and orientation match those of the target (Petrov, Carandini, & McKee, 2005). Here, we explore how various spatial characteristics of the iso-oriented and frequency-matched surround, such as surround phase and spatial layout, affect suppression. We manipulated surround geometry (annulus ring, half annulus, and bow tie) and its separation from the target (both laterally and in depth) and varied the position of the half-annulus and bow-tie surrounds with respect to Gabor target's orientation and with respect to its location in the visual field (i.e., radial vs. tangential surrounds). We also compared monoptic, dichoptic, and binocular surround suppression. Except for a significant radial-tangential anisotropy, only the area of the surround and the lateral separation between the surround and target had a significant effect on the magnitude of suppression. We showed that, although suppression amplitude remains constant with stimulus eccentricity, the lateral extent of suppression scales in proportion to the eccentricity. The most surprising finding was that the extent of surround suppression does not scale with stimulus size or spatial frequency. We suggest that the properties of surround suppression are best explained by a mechanism that selects salient targets for subsequent saccades.

Contrast Sensitivity↗

PubMed2006

Collinear facilitation is largely uncertainty reduction.

When flanked by collinear Gabor patches, detection thresholds for a target Gabor patch improve by up to a factor of 2. This result has been interpreted as evidence for collinear facilitation. However, facilitation has been observed only for targets near detection threshold, where observers seem uncertain about the location and other properties of the stimulus. So the effect of the flankers may be to reduce this uncertainty. If this is true, then other cues to target location should produce a similar improvement in thresholds. To test this hypothesis, we measured contrast detection thresholds for a Gabor target alone, and in the presence of either a faint circle surrounding the target location, or two high-energy flanking Gabor patches. We also used an adaptive procedure to measure the slope of the psychometric function to determine whether the slopes were considerably lower in the presence of location cues or flanking Gabors, as predicted by signal detection theory when uncertainty is reduced. As observed previously, the presence of collinear flankers improved detection thresholds by a factor of two. Yet, on average, the circle alone accounted for the most of the facilitation; for three of our five observers, it improved thresholds as much as the collinear flankers. Other cues that specified target location produced similar improvements in detection thresholds. The slopes of the psychometric functions were much shallower in the presence of these location cues or the collinear flankers compared to the target-alone condition. This change in the slopes indicates that the threshold improvement is largely due to a significant reduction in uncertainty.

Contrast Sensitivity↗

PubMed2005

Stereo sensitivity depends on stereo matching.

Stereoacuity thresholds, measured with bar targets, rise as the absolute disparity of the bars is increased. One explanation for this rise is that, as the bars are moved away from the fixation plane, the stereo system uses coarser mechanisms to encode the bars' disparity; coarse mechanisms are insensitive to small changes in target disparity, resulting in higher thresholds. To test this explanation, we measured stereoacuity with a 6 degrees wide 3 cpd grating presented in a rectangular envelope. We varied the disparity of the grating and its edges (envelope) parametrically from 0 to 20 arcmin (i.e., through one full period). To force observers to make judgments based on carrier disparity, we then varied the interocular phase incrementally from trial-to-trial while keeping edge disparity fixed for a given block of trials. The pedestal phase disparity of the grating necessarily cycles through 360 degrees, back to zero disparity, as the edge disparity increases monotonically from 0 to 20 arcmin. Unlike mechanisms that respond to bars, the mechanism that responds to the interocular phase disparity of the grating should have the same sensitivity at 20 arcmin disparity (360 degrees of phase) as it has at zero disparity. So, if stereoacuity were determined by the most sensitive mechanism, thresholds should oscillate with the pedestal phase disparity. However, these gratings are perceived in depth at the disparity of their edges. If stereoacuity were instead determined by the stereo matching operations that generate perceived depth, thresholds should rise monotonically with increasing edge disparity. We found that the rise in grating thresholds with increasing edge disparity was monotonic and virtually identical to the rise in thresholds observed for bars. Stereoacuity is contingent on stereo matching.

Adult↗

PubMed2005

Motion grouping impairs speed discrimination.

Discriminating between two speed signals is harder when they are seen as part of a single trajectory, compared to the case when they appear as distinct entities. Observers were asked to judge which half of a display had dots that were moving faster. This was done under two main conditions: when dot motion appeared to continue across the boundary between the two halves, and when it moved parallel to the boundary. Speed discrimination thresholds were elevated when motion in the two halves appeared to cross the boundary compared to the case when motion was parallel to the boundary. Extensive practice improved performance until speed discrimination in the two cases was virtually indistinguishable. The addition of noise caused the original effect to reappear, i.e., thresholds were elevated when motion continued across the border. Our results suggest that the local differences in velocity on either side of border are ignored when motion appears to cross the border. Instead the visual system seems to enforce an a priori assumption that when motion continues across a boundary it belongs to a common motion path.

Cues↗

PubMed2005

Suppression of monocular visual direction under fused binocular stimulation: evoked potential measurements.

Visual evoked potentials (VEPs) were recorded in response to a vernier onset/offset target presented to one eye that was combined with matching static targets in the other eye. The monocular response was dominated by a negative peak at 160 ms that occurred after a set of offsets was introduced into a one-dimensional random bar pattern. The static targets produced no discernible VEP response by themselves, but when fused binocularly with the oscillating vernier target, they produced shifts in perceived visual direction that influenced the VEP response. A vernier target fused with static vertical bars was perceived to alternate in depth between a flat surface and one broken into two interleaved surfaces. The response to this "surface-breaking" was as large or larger than the response to the monocular vernier offset. This response was much reduced when the oscillating vernier was fused with a static offset vernier (5' offset) that produced a percept of segregated regions moving in depth. Apparently, the VEP is strongly driven by shifts in visual direction that alter surface, texture, or contour contiguity.

Depth Perception↗

PubMed2005

A VEP measure of the binocular fusion of horizontal and vertical disparities.

PURPOSE: Because of the lateral separation of the orbits, the retinal images differ in the two eyes. These differences are reconciled into a single image through sensory and motor fusional mechanisms. This study demonstrates electrophysiologically the effects that normal horizontal and vertical fusional processes have on the processing of monocular position signals. METHODS: VEPs were recorded in 16 healthy adults in response to a vernier onset-offset target presented to one eye. The vernier offsets appeared and disappeared at 2 Hz and were introduced into bar targets that were oriented either vertically (horizontal offsets) or horizontally (vertical offsets). The magnitude of the offsets was varied over the range of 0.5 to 10 arc min. VEP amplitude was measured as a function of the size of the dynamic offset under monocular viewing conditions and in the presence of two different static targets presented to the other eye. One of the static targets matched the dynamic test, except that it had no vernier offsets. The other static target, the static pedestal, matched the dynamic test, but contained a set of static vernier offsets in locations corresponding to the locations of the dynamic offsets presented to the other eye. RESULTS: VEP amplitude was a monotonically increasing function of vernier offset size under monocular viewing conditions. The addition of the static target without offsets in the other eye resulted in an increased amplitude VEP response. The addition of the static target with vernier offsets resulted in a decrease in VEP amplitude for both horizontal and vertical disparities. CONCLUSIONS: The normal process of fusion results in a single visual direction. To obtain a single visual direction, the visual system must synthesize a binocular visual direction that differs from the monocular components. One of the conditions (the static pedestal with offsets) produces binocular visual direction shifts that degrade the appearance of vernier onset-offset, and reduce VEP amplitude for both horizontal and vertical disparities. This characteristic evoked response marker is a promising tool for measuring binocular fusion objectively in patients with strabismus.

Adult↗

PubMed2004

What is the depth of a sinusoidal grating?

Stereo matching of a textured surface is, in principle, ambiguous because of the quasi-repetitive nature of texture. Here, we used a perfectly repetitive texture, namely a sinusoidal grating, to examine human stereo matching for repetitive patterns. Observers matched the depth of a vertical grating segment, 6-deg wide and presented in a rectangular envelope at or near the disparity of the segment edges. The interocular phase of the carrier also influenced stereo matching, producing shifts in depth arrayed around the plane specified by the edges. The limiting disparity for the edge matches was 40-60 arcmin, independent of the spatial frequency of the carrier. One explanation for these results is that first-order disparity energy mechanisms, tuned to lower spatial frequencies, respond to the edge disparities, while showing little response to the interocular phase of the carrier. In principle, these first-order low frequency mechanisms could account for edge-based stereo matching at high contrasts. But, edge matching is also observed at carrier contrasts as low as 5%, where these low frequency mechanisms are unlikely to detect the grating stimulus. This result suggests that edge matching for gratings depends on coarse-scale second-order stereo mechanisms, similar to the second-order mechanisms that have been proposed for encoding two-dimensional texture. We conclude that stereo matching of gratings (or any other texture) depends on a combination of responses in both coarse-scale second-order and fine-scale first-order disparity mechanisms.

Contrast Sensitivity↗

PubMed2004

Coarse scales, fine scales, and their interactions in stereo vision.

Human stereo vision can resolve remarkably small depth differences between two stimuli, but the smallest resolvable difference is usually that between stimuli located near the plane of fixation. As distance from this plane increases, so does the smallest detectable increment in disparity. We examined this loss of resolution by comparing disparity discrimination thresholds for single-scale and multi-scale stimuli as a function of the pedestal disparity. For single-scale gratings, disparity thresholds display phase constancy; thus, their spatial thresholds vary reciprocally with grating spatial frequency. For multi-scale gratings, with components separated in frequency by two or three octaves, disparity thresholds display two types of interaction between coarse-scale and fine-scale components: facilitation when pedestal disparities are moderate and interference when they are large. The facilitation extends the disparity range that yields the low thresholds associated with fine-scale components, limiting the loss of disparity resolution for multi-scale stimuli.

Contrast Sensitivity↗

PubMed2004

Sensitivity to depth relief on slanted surfaces.

The finest stereoacuity is known to depend on the disparity of a target relative to other visible points. Here we show that a more important factor in determining sensitivity to displacement can be the disparity of a target relative to an invisible interpolation plane through other neighboring points. We tested the sensitivity of observers to displacements of the central column of a regular grid of dots that was either fronto-parallel or slanted about a vertical axis. We found that subjects' sensitivity to displacement was better predicted by a model based on the disparity of a target with respect to the grid plane than it was by a model based on disparity with respect to other reference points. In control conditions carried out on one subject, we found that this result did not depend on adaptation to the grid slant because it also occurred when the direction of grid slant varied from trial to trial. Nor did it depend on the perception of slant, because the data were similar for trials on which the grid was perceived as approximately fronto-parallel or markedly slanted. Our results indicate that sensitivity to the depth component of the target displacement is based on disparity relative to a local reference plane.

Cues↗

PubMed2004

Disparity increment thresholds for gratings.

The classic increment disparity threshold function rises steeply, usually exponentially, with disparity pedestal. Thus a smaller difference in stereoscopic depth can be resolved the nearer it is to the fixation plane. This result has been obtained with relatively broad-bandwidth stimuli. We show here that the increment threshold function for narrow-bandwidth stimuli differs subtly from the classic function: Thresholds vary only modestly over a +/- quarter-cycle pedestal range, by a factor of about 2, and frequently show a dip, yielding best stereo acuity not at the fixation plane but at moderate disparities (20 degrees-30 degrees in phase) on either side of it. Though the dip has not been noted previously, it is consistent with models of disparity processing in which filter sensitivity or selectivity is greatest at a disparity of zero. Moreover, the relatively flat increment threshold function observed at any one scale is compatible with a steeply rising function for broad-bandwidth stimuli.

Depth Perception↗

PubMed2004

Visual search in clutter.

Detecting a target in clutter is particularly difficult because the observer must monitor many potential locations to find the target, and because the clutter itself might mask the target. To investigate whether contemporary models of search can account for visual search in clutter, we measured the detection of an oblique string of five aligned dots presented at an unknown location as a function of noise density. Observers judged which of two 200 ms intervals contained the signal string. At a given density, noise composed of oriented pairs of dots greatly degraded detection compared to random dot noise, especially if the paired noise shared the same orientation as the signal. Increasing the orientation difference between the paired noise and the signal improved detection, as did increasing signal length. We successfully modeled these results with an array of multi-scaled oriented detectors optimally tuned for the signal string. These results indicate that search for these simple patterns in noise is based on competing responses in oriented filters.

Attention↗

PubMed2003

The pattern of visual deficits in amblyopia.

Amblyopia is usually defined as a deficit in optotype (Snellen) acuity with no detectable organic cause. We asked whether this visual abnormality is completely characterized by the deficit in optotype acuity, or whether it has distinct forms that are determined by the conditions associated with the acuity loss, such as strabismus or anisometropia. To decide this issue, we measured optotype acuity, Vernier acuity, grating acuity, contrast sensitivity, and binocular function in 427 adults with amblyopia or with risk factors for amblyopia and in a comparison group of 68 normal observers. Optotype acuity accounts for much of the variance in Vernier and grating acuity, and somewhat less of the variance in contrast sensitivity. Nevertheless, there are differences in the patterns of visual loss among the clinically defined categories, particularly between strabismic and anisometropic categories. We used factor analysis to create a succinct representation of our measurement space. This analysis revealed two main dimensions of variation in the visual performance of our abnormal sample, one related to the visual acuity measures (optotype, Vernier, and grating acuity) and the other related to the contrast sensitivity measures (Pelli-Robson and edge contrast sensitivity). Representing our data in this space reveals distinctive distributions of visual loss for different patient categories, and suggests that two consequences of the associated conditions--reduced resolution and loss of binocularity--determine the pattern of visual deficit. Non-binocular observers with mild-to-moderate acuity deficits have, on average, better monocular contrast sensitivity than do binocular observers with the same acuity loss. Despite their superior contrast sensitivity, non-binocular observers typically have poorer optotype acuity and Vernier acuity, at a given level of grating acuity, than those with residual binocular function.

Adolescent↗

PubMed2002

Evidence for surface-based processing of binocular disparity.

It is convenient to think of an object's location as a point within a Cartesian framework; the x axis corresponds to right and left, the y axis to up and down, and the z axis to forward or backward. When an observer is looking straight ahead, binocular disparities provide information about distance along the z axis from the fixation plane. In this coordinate system, changes in disparity are treated as independent of changes in location along the orthogonal x and y axes. Does the human visual system use this three-dimensional coordinate system, or does it specify feature location in a coordinate frame determined by other nearby visible features? Here we show that the sensitivity of the human stereo system is determined by the distance of points with respect to a local reference plane, rather than by the distance along the z axis with respect to the fixation plane. There is a distinct advantage to using a local frame of reference for specifying location. It obviates the need to construct a complex three-dimensional space in either eye-centered or head-centered coordinates that must be updated with every shift of the eyes and head.

Biophysical Phenomena↗

PubMed2002

Stereo transparency and the disparity gradient limit.

Several studies (Vision Research 15 (1975) 583; Perception 9 (1980) 671) have shown that binocular fusion is limited by the disparity gradient (disparity/distance) separating image points, rather than by their absolute disparity values. Points separated by a gradient >1 appear diplopic. These results are sometimes interpreted as a constraint on human stereo matching, rather than a constraint on fusion. Here we have used psychophysical measurements on stereo transparency to show that human stereo matching is not constrained by a gradient of 1. We created transparent surfaces composed of many pairs of dots, in which each member of a pair was assigned a disparity equal and opposite to the disparity of the other member. For example, each pair could be composed of one dot with a crossed disparity of 6' and the other with uncrossed disparity of 6', vertically separated by a parametrically varied distance. When the vertical separation between the paired dots was small, the disparity gradient for each pair was very steep. Nevertheless, these opponent-disparity dot pairs produced a striking appearance of two transparent surfaces for disparity gradients ranging between 0.5 and 3. The apparent depth separating the two transparent planes was correctly matched to an equivalent disparity defined by two opaque surfaces. A test target presented between the two transparent planes was easily detected, indicating robust segregation of the disparities associated with the paired dots into two transparent surfaces with few mismatches in the target plane. Our simulations using the Tsai-Victor model show that the response profiles produced by scaled disparity-energy mechanisms can account for many of our results on the transparency generated by steep gradients.

Female↗

PubMed2002

Contour completion through depth interferes with stereoacuity.

Local disparity signals must interact in visual cortex to represent boundaries and surfaces of three-dimensional (3D) objects. We investigated how disparity signals interact in 3D contours and in 3D surfaces generated from the contours. We compared flat (single disparity) stimuli with curved (multi-disparity) stimuli. We found no consistent differences in sensitivity to contours vs. surfaces; for equivalent amounts of disparity, however, observers were more sensitive to flat stimuli than curved stimuli. Poor depth sensitivity for curved stimuli cannot be explained by the larger range of disparities present in the curved surface, nor by disparity averaging, nor by poor sensitivity to the largest disparity in the stimulus. Surprisingly, sensitivity to surfaces curved in depth was improved by removing portions of the surface and thus removing disparity information. Stimulus configuration had a profound effect on stereo thresholds that cannot be accounted for by disparity-energy models of V1 processing. We suggest that higher-level 3D contour or 3D shape mechanisms are involved.

Form Perception↗

PubMed2002

Predicting future motion.

Predicting the future course of a moving target is invaluable for planning actions. We used trajectory detection in noise to investigate this predictive capability. Using a contrast probe technique, we showed that in noise, contrast increments are more easily seen at the end of the trajectory than at the beginning. Analyses of the contrast data revealed that the improvement at the end of the trajectory was due to a substantial reduction in the number of detectors monitored, as well as to an increase in the gain of detectors responding to the increment. It appears that the first segment of the trajectory acts as an automatic cue that draws attention to subsequent segments of the trajectory, leading to enhanced detectability for predictable motion trajectories.

Contrast Sensitivity↗