Biomedical subjects

Suzana Martinovic

Publications and source records attributed to Suzana Martinovic.

3 recordsLinked to original sources

PubMed2003

Duplex foldamers from assembly induced folding.

Oligoamide strands 1, 2, and 3, consisting of 4-H-bond units, were originally designed to form noncovalent polymers based on the expectation that they would adopt an extended conformation. Instead of assembling into the expected supramolecular polymer through their 4-H-bond units, the 1:1 mixture of 1 and 2 was found to form a highly stable dimeric species. To dimerize, the H-bonding sequences of 1 and 2 can only adopt a folded (stacked) conformation. The self-assembly of 3 was also found to adopt a similar folded duplex conformation. These novel duplex foldamers are very stable. They were characterized by 1D and 2D 1H NMR, VPO, and mass spectral (ESI) studies.

Biomimetic Materials↗

PubMed2003

An extremely stable, self-complementary hydrogen-bonded duplex.

This paper describes the design, synthesis and characterization of a self-complementary six-H-bonded duplex with an association constant greater than 10(9) M(-1) in CHCl3.

Drug Stability↗

PubMed2002

Creating nanocavities of tunable sizes: hollow helices.

A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 A to >30 A across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.

Hydrogen Bonding↗