Biomedical subjects

Susanna Anglé

Publications and source records attributed to Susanna Anglé.

4 recordsLinked to original sources

PubMed2006

Increased aortic intima-media thickness in 11-year-old healthy children with persistent Chlamydia pneumoniae seropositivity.

OBJECTIVE: The relationship between Chlamydia pneumoniae (Cpn) infection and arterial measures of preclinical atherosclerosis has remained controversial. Because atherogenesis begins in early life, we examined whether carotid and aortic intima-media thickness (IMT) and brachial artery endothelial function are associated with Cpn seropositivity in children. METHODS AND RESULTS: Cpn-specific IgG and IgA antibodies were assessed by enzyme immunoassay in 199 healthy children followed-up annually from 7 to 11 years of age. Carotid (cIMT) and aortic IMT (aIMT), and brachial artery flow-mediated dilatation (FMD) were measured in 137 of the 199 children at the age of 11 years using high-resolution ultrasound. Children with persistent IgG and/or IgA seropositivity to Cpn had significantly increased aIMT compared with seronegative children (IgG< or =45 and IgA< or =12 enzyme immunounits) or children with transient Cpn seropositivity (seronegative, 0.496 [0.054]; transient, 0.494 [0.061]; and persistent, 0.532 [0.086] mm; P<0.05 for trend). This trend was not explained by traditional atherosclerotic risk factors or pubertal stage. cIMT and FMD were not associated with Cpn seropositivity. CONCLUSIONS: Eleven-year-old children with persistent Cpn seropositivity show increased aIMT but not cIMT, suggesting that Cpn may affect the aortic wall, the site where the earliest atherosclerotic lesions are known to occur, in otherwise healthy children.

Antibodies, Bacterial↗

PubMed2006

[Not Available].

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Journal Article↗

PubMed2005

Serum lipid profiles poorly correlate with Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus seropositivity in prospectively followed-up healthy children.

OBJECTIVE: Chronic Chlamydia pneumoniae (Cpn), Helicobacter pylori (Hp), and herpes virus infections have been associated with atherogenic serum lipid profile and an excess of cardiovascular events in adults. Because mechanisms leading to atherosclerosis are active since early childhood, we examined whether Cpn, Hp, or cytomegalovirus (CMV) seropositivity relates to serum lipid, lipoprotein, or apolipoprotein concentrations in children. We also looked for factors increasing probability of Cpn seropositivity in children. METHODS AND RESULTS: Cpn-specific IgG and IgA, as well as Hp-specific and CMV-specific IgG antibodies were assessed by enzyme immunoassay in 199 apparently healthy children, followed-up from 7 to 11 years of age. Serum lipid profiles were studied at the ages of 7, 9, and 11 years using standard methods. Neither seroconversion to Cpn IgG or IgA antibody positivity nor persistent seropositivity for Cpn, Hp, or CMV was associated with proatherogenic serum lipid values. Children with siblings were more likely to possess Cpn antibodies than children without siblings (IgG: OR, 5.24; 95% CI, 1.63 to 16.82; IgA: OR, 3.32; 95% CI, 1.15 to 9.57). CONCLUSIONS: These data suggest that contrary to the observations in adults, Cpn, Hp, and CMV seropositivity in otherwise healthy children is not associated with disturbances in serum lipid profile.

Antibodies, Bacterial↗

PubMed2005

Weight gain since infancy and prepubertal body dissatisfaction.

OBJECTIVE: To investigate whether body dissatisfaction at prepuberty is associated with preceding changes in relative weight since infancy. DESIGN: A longitudinal cohort study. Follow-up of weight and height from age 7 months to 8 years; evaluation of body dissatisfaction at age 8 years. SETTING AND PARTICIPANTS: The subjects were 205 girls and 230 boys participating in a prospective randomized atherosclerosis prevention trial in Finland. MAIN OUTCOME MEASURES: A pictorial instrument was used in measuring estimated current and desired body sizes. A difference between the 2 indicated body dissatisfaction. RESULTS: Children, particularly girls, who wished to be thinner at age 8 years had, on average, a more rapid increase in relative weight between ages 3 and 8 years compared with other children. Slopes of the average trends of change in weight differed significantly between the children wishing to be thinner, those who were satisfied with their size, and those who wished to look heavier (P = .002 in girls; P = .02 in boys). CONCLUSION: Body dissatisfaction at prepuberty may reflect changes in weight during the preceding several years.

Body Height↗