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Biomedical subjects

Suck Won Kim

Publications and source records attributed to Suck Won Kim.

24 records · Page 2Linked to original sources

Gender differences in pathological gamblers seeking medication treatment.

Gender differences in pathological gambling disorder (PGD) have received little investigation. This study was constructed to detail the demographic and phenomenological differences in men and women with PGD. We assessed gender differences in 131 subjects with PGD who were evaluated in terms of demographic characteristics, clinical features of PGD, and treatment history. Seventy-eight (60%) subjects were women, and 53 (40%) were men. Men had an earlier age of onset of gambling behavior, while women progressed to pathological gambling sooner after beginning to gamble. In terms of gambling behavior, men were more likely to engage in blackjack, cards, sporting events, and the track, whereas women played slot machines and bingo. Women reported that loneliness was the major trigger to gambling, while men were more likely to gamble secondary to sensory stimuli. Although men were as likely as women to have filed bankruptcy because of gambling, women were more likely to have written bad checks and men were more likely to have lost significant savings. Both groups were equally likely to seek treatment, but Gamblers Anonymous (GA) and outpatient therapy were reported equally ineffective in reducing gambling symptoms. There appear to be some gender differences in the clinical features of PGD, and these differences may have treatment implications.

Adult↗

Temperament and early environmental influences in kleptomania.

The purpose of this investigation was to shed light on the temperament and early life experiences of people suffering from kleptomania. Twelve outpatients (five men [41.6%]; seven women [58.3%]; mean age, 39.6 +/- 11.0 years) who met DSM-IV criteria for kleptomania and had no other axis I disorders by Structured Clinical Interview for DSM-IV (SCID) completed the Tridimensional Personality Questionnaire (TPQ) and the Parental Bonding Instrument (PBI). Patients with kleptomania had significantly higher novelty-seeking scores (P =.001), higher harm-avoidance scores (P =.005), and lower reward-dependence scores (P =.023) than normal controls. The kleptomania subjects had significantly lower maternal and paternal care scores, and lower maternal protection scores, than the normative values (P <.05). Neither TPQ nor PBI scores correlated with illness severity. These findings suggest that an understanding of early parenting behavior and a dimensional approach to the personality of kleptomaniacs may offer insight into this disorder and provide clues to treatment strategies.

Adult↗

Clinical characteristics and associated psychopathology of 22 patients with kleptomania.

The current study was constructed to detail the demographic, phenomenological, family history, and treatment response data in a group of patients with kleptomania. Twenty-two subjects, drawn from an outpatient population, with uncontrollable urges to steal completed both a semistructured interview that focused on stealing behavior and the Structured Clinical Interview for DSM-IV (SCID). Fourteen women and eight men reported an average age of onset of 16 years and an average symptom duration of 21 years. Sixteen patients (73%) reported particular triggers for their urges to steal. Seventeen subjects (77.3%) qualified for a lifetime axis I diagnosis and 9 (40.9%) qualified for a current axis I disorder other than kleptomania. These patients reported severe symptoms, with 15 subjects (68%) reporting intense shame or guilt following the thefts. We conclude that kleptomania is a distressing and disabling disorder associated with high rates of psychiatric comorbidity.

Adolescent↗

Safety of high-dose naltrexone treatment: hepatic transaminase profiles among outpatients.

OBJECTIVES: This study was carried out to test the hypothesis that the hepatic safety profile of prolonged high-dose oral naltrexone (150 mg/d) is acceptable if over-the-counter analgesic use is restricted. METHODS: Data from 41 consecutive outpatients with impulse-control disorder receiving naltrexone therapy were analyzed. RESULTS: The mean treatment duration was 328 days and the mean naltrexone dose was 142 mg/d. Pretherapy/posttherapy mean aspartate transaminase and alanine transaminase levels in the naltrexone-alone group were 21.79/22.54 and 21.74/21.49 U, respectively (all within reference range). CONCLUSIONS: Although limited in scope, these findings support the hypothesis that long-term use of high-dose oral naltrexone is safe in otherwise healthy patients with impulse-control disorders who restrict their intake of acetaminophen, aspirin, or nonaspirin nonsteroidal anti-inflammatory drugs (NSAID). However, confirming studies are needed.

Adolescent↗

Sex differences in pain and hypothalamic-pituitary-adrenocortical responses to opioid blockade.

OBJECTIVE: Sex differences in pain sensitivity and stress reactivity have been well documented. Little is known about the role of the endogenous opioid system in these differences. This study was conducted to compare adrenocortical, pain sensitivity, and blood pressure responses to opioid blockade using naltrexone in men and women. METHODS: Twenty-six participants completed 2 sessions during which placebo or 50 mg of naltrexone was administered, using a double-blind, counterbalanced design. Thermal pain threshold and heat tolerance were assessed. Participants also rated pain during a 90-second cold pressor test (CPT) and completed the McGill Pain Questionnaire (MPQ) after each pain challenge. Blood and saliva samples and cardiovascular and mood measures were obtained throughout the sessions. RESULTS: Plasma cortisol, adrenocorticotropin, beta endorphin, prolactin, and salivary cortisol levels increased similarly in men and women after naltrexone administration compared with placebo. Women reported more pain during both pain procedures and had lower thermal pain tolerance. In response to naltrexone, women exhibited reduced blood pressure responses and reduced MPQ pain ratings after CPT. No effects of naltrexone on these measures were found in men. CONCLUSIONS: Although men and women exhibited similar hormonal responses to opioid receptor blockade, women reported less pain and showed smaller blood pressure responses during CPT. Results suggest differential effects of the endogenous opioid system on pain perception and blood pressure in men and women.

Adrenocorticotropic Hormone↗

Dissociative symptoms in pathological gambling.

BACKGROUND: Dissociation is increasingly being recognized as both a normal process and as a psychophysiological aspect of a number of mental disorders. The purpose of this investigation was to shed light on a possible link between dissociation and pathological gambling, a relatively common disorder whose phenomenology remains understudied. SAMPLING AND METHODS: Thirty adult outpatients who met DSM-IV criteria for pathological gambling and had no comorbidity were administered the Dissociative Experiences Scale (DES). RESULTS: The pathological gamblers had DES scores that did not significantly differ from those reported by normal controls (t = -0.620; d.f. = 29; p = 0.540). CONCLUSIONS: Pathological gamblers do not appear to experience dissociative symptoms (as reflected on the DES) at a rate significantly different from those found in normal controls. Because pathological gamblers seeking medication treatment, as in this study, may differ from others with pathological gambling, further studies are needed.

Adult↗