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Biomedical subjects

Stephen Wright

Publications and source records attributed to Stephen Wright.

At least 19 recordsLinked to original sources
PubMed2004

Development of a questionnaire to evaluate the information needs of cancer patients: the EORTC questionnaire.

Information disclosure is one of the key areas of support that patients may receive. The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group has a group working on the development of a questionnaire that evaluates information received by cancer patients at different stages of their disease--EORTC QLQ-INFO30. This instrument is being developed by professionals from most European regions. The questionnaire aims to evaluate the information received by cancer patients on different areas of the disease, diagnosis, treatment and care. Besides, the instrument also assesses qualitative aspects of the information they have received. The present paper presents the first two phases of the module development process that include literature review, interviews with patients and professionals, and formulation of the items. All these steps have been carried out in different countries and have been approved by the EORTC QLG.

Adaptation, Psychological↗
PubMed2002

Immunisation of mice against neosporosis.

In the present study a murine encephalitis model was used to investigate if protection against neosporosis could be achieved by immunisation. Groups of 10 mice were immunised with a sublethal dose of live Neospora caninum tachyzoites, N. caninum antigens incorporated into iscoms, N. caninum lysate mixed with Quil A, or N. caninum lysate in PBS. Control mice were given Quil A only. Challenge infection with 2.5x10(6) N. caninum tachyzoites resulted in clinical symptoms that remained until the end of the experiment in the controls. In contrast, mice immunised with live parasites or parasite lysate in Quil A only showed mild and transient symptoms. Of nine mice immunised with N. caninum iscoms, seven recovered while two died. Most severely affected were the mice immunised with parasite lysate only; all of them died within 28 days post-infection. Histological examination and scoring of brain lesions gave a significantly lower (P<0.0001) lesion score in mice immunised with live parasites than in controls. The groups immunised with iscoms or lysate and Quil A also had reduced lesion scores (P<0.04 and 0.07, respectively) but not the group given parasite lysate alone. The lesions seen in the latter group differed from those in the other groups. There was less cellular reaction and more tachyzoites indicating an active infection. The N. caninum specific antibody responses and cytokine production (IFN-gamma, IL-4 and IL-5) of splenocytes were analysed at the time of challenge infection. The results suggest a correlation between protection and high levels of IFN-gamma. Also, the immune responses recorded in mice immunised with parasite lysate without adjuvant were relatively weak and more towards the Th2 type, when compared with the other immunisation schedules. This is consistent with the weaker inflammatory response observed in the brains of these mice.

Adjuvants, Immunologic↗
PubMedDate not supplied

Prayer power.

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Health Status↗
PubMedDate not supplied

Feel the burn.

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Adaptation, Psychological↗
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Beware self-worship.

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Conflict, Psychological↗
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Need to be heard.

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Empathy↗
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Speak up for life.

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Humans↗
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Eastern light.

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Attitude of Health Personnel↗
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Blind believers.

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Culture↗
PubMedDate not supplied

Deconstructing nursing from practice to theory.

People often talk about 'basic' nursing care as if it is the simplest thing in the world: it looks so easy that anyone could do it. But there is more to it than meets the eye. We asked three prominent nurses to spend time watching individual nurses going about their business in an attempt to get to the bottom of this thing called nursing care. And when you look beyond the surface it is obvious delivering nursing care is neither simple nor basic.

Attitude of Health Personnel↗
PubMedDate not supplied

Handle with care.

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Humans↗
PubMedDate not supplied

Open your mind.

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Attitude to Health↗