Biomedical subjects

Slobodan Savović

Publications and source records attributed to Slobodan Savović.

7 recordsLinked to original sources

PubMedDate not supplied

[The effect of age on the sense of smell in health individuals].

INTRODUCTION: A need for research of the olfactory function exists in everyday clinical work. The aim of this study was to determine standards for perception and identification thresholds regarding olfactory substances in healthy subjects in regard to their age. MATERIAL AND METHODS: The research included 120 healthy examinees (60 women and 60 men) classified according to age into three age groups (20-30, 31-40, 41-50 years of age). This examination was done using Fortunato-Niccolini's method. RESULTS AND DISCUSSION: The results of this work show that olfactory function becomes significantly weaker after the age of forty. Thresholds of perception in correlation with thresholds of identification for examined olfactory substances are significantly lower in older age groups. CONCLUSION: A gradual loss of olfactory capability with age can be explained by gradual destruction of olfactory cells and fibres of olfactory nerves during life.

Adult↗

PubMedDate not supplied

[Olfactory perception in women with physiologically altered hormonal status (during pregnancy and menopause].

INTRODUCTION: Olfaction is considered to be the ability to: perceive, conduct and recognize scents and odors. With its numerous connections to the limbic system and reticular formation, the olfactory system affects regulation of numerous vegetative functions, visceral functions and sexual behavior. Since estrogen and progesterone protect the olfactory function, changes in their levels in particular physiological states in women (in pregnancy and posmenopause) exert an influence on the ability to feel and recognize smells. It has its role in creating emotions and adjustment of visceral and vegetative response to particular emotional states. Also, it represents the connection between higher cortical functions and the endocrine system. MATERIAL AND METHODS: Our investigation was performed at the Ear, Nose and Throat Clinic in Novi Sad. The research included 80 healthy women classified into 4 groups; 20 women aged between 20 and 30; 20 women in the first trimester of pregnancy aged between 20 and 30; 20 premenopausal women aged between 41 and 50; and 20 women at least 3 years in postmenopause, aged between 41 and 50. For our research we used an olfactometer and the Fortunato-Niccolini method. RESULTS AND DISCUSSION: In pregnancy the thresholds of perception (TP) and identification (TI) of examined substances were slightly lower in comparison to nonpregnant women of the same ages, but without any statistical significance (p > 0.05). In climacteric-postmenopausal women there was a significant decrease of olfactory ability in comparison to nonmenopausal women of the same ages (p < 0.01). CONCLUSION: All changes of the olfactory function in pregnancy are explained by mental changes of pregnant women as well as their hormonal status. Significant decrease of olfactory ability in postemnopause is explained by decline in sexual hormone levels.

Adult↗

PubMedDate not supplied

[Sense of smell in patients with bilateral nasal polyposis].

INTRODUCTION: Sense of smell is susceptible to various changes, both in physiological and in numerous pathological conditions. Of quantitative disorders of smell, hyposmia and anosmia are quite common, whereas of qualitative disorders parosmia is most frequent. The aim of this paper was to examine impact of bilateral nasal polyposis on olfactory function. MATERIAL AND METHODS: The research was carried out at the Nose, Ear and Throat Clinic in Novi Sad. It included 80 examinees, 40 (20 male, 20 female) with bilateral nasal polyposis, while 40 examinees belonged to the control group (20 male, 20 female) without symptoms of nasal polyposes. Fortunato-Niccolini olfactometer was used for this examination. RESULTS AND DISCUSSION: In patients with bilateral nasal polyposis the average perception threshold values for examined odors were 15.50 ccm of odorous air, while in the control group they were 10.20 ccm of odorous air. The average identification threshold values for examined odors in patients with bilateral nasal polyposis were 18.80 ccm of odorous air, while in the control group they were 13.55 ccm of scented air. T-test showed that values of both thresholds were statistically significantly higher (p<0.01) in patients with bilateral nasal polyposis in relation to the control group. CONCLUSION: Olfactory deficit in patients with bilateral nasal polyposis is explained by difficult or impossible passage of odors into the olfactory region.

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PubMedDate not supplied

[Rhinolithiasis].

INTRODUCTION: A rhinolith is a rock which forms in the nose. It occurs from the solidification of mucus and nasal debris: by mineral salts, calcium, magnesium phosphate and carbonate, and it leads to unilateral obstruction of the nasal airway followed by inflammatory changes of the nasal mucus membrane and paranasal cavities. This inflammatory process may lead to a purulent form with complications, intracranial propagation and dacryocystitis. CASE REPORT: This is a case report of a patient with rhinolithiasis, 30 years of age, complaining of breathing difficulties for 10 years, with nasal secretion, reduced olfactory function and headaches. She underwent the following procedures: frontal rhinoscopy, epipharyngoscopy, nasal mucus analysis (fungi and bacteria), x-ray check-up as well as pathohistological analysis of the removed rhinolith. DISCUSSION AND CONCLUSION: The significance of computer tomography of paranasal cavities was confirmed in coronal lines, as the most valid radiological analysis which provides adequate diagnosis, differential diagnosis and helps in making the decision on surgical treatment. Surgery is obligatory and in most cases it is endonasal endoscopy. Bigger nasal stones (rhinoliths), progressing into the surrounding anatomic structures, are treated using rhinotomy and trepanation (Caldweell-Luc). In cases of greater rhynoliths with propagation into neighboring anatomic areas, cases of surgical treatment by lateral rhynotomy and trepancy of the sinuses (Caldwel-Luc) were shown.

Adult↗

PubMedDate not supplied

[Value of panendoscopy in metastases of unknown origin].

INTRODUCTION: Neck metastases of unknown origin are metastatic solid tumors wth primary undetactable by physical examination, chest x-ray, rutine blood and urine studies and histologic evaluation. MATERIAL AND METHODS: This study included 77 patients of both sexes, average age 57 years, undergoing a diagnostic procedure at ENT clinic, Clinical Center Novi Sad, in the period from 1992 to 2001. RESULTS: The prymary tumor was detected in 51% of all cases by panendoscopy and bilateral tonsillectomy. In 14 of 26 patients (54%), in whom the site of the primary tumor was not detected, after telecobalt therapy and radical neck dissection, no relapses occurred. Pathohistological examination revealed planocellular carcinoma in 50 (65%) cases, transitional cell carcinoma in 9 (11.7%) cases and lymphoma in 7 (9.1%) cases. CONCLUSION: Cervical metastases with unknown primary tumor are the first sign of head and neck malignant disease. Panendoscopy with bilateral tonsillectomy and multiple mucosal biopsies are necessary procedures in detecting the primary tumor site.

Adult↗

PubMedDate not supplied

[The smooth tracking test and rotation stimulation test in disorders of the vestibular system caused by carbamazepine].

The examination was carried out in 10 healthy volunteers of both sexes, of the average age of 32.5 years, of the average weight of 77.4 kg. Seven volunteers were males. After dosage of 800 mg of carbamazepine in 2/7 volunteers the finding was unchanged, in 3/7 second stage disturbance was found and in 2/7 third stage of disturbance in the smooth tracking test was found. After the administration of 1200 mg the findings were worse, 1/10 volunteers had unchanged findings compared with control dose, 6/10 had second stage disturbance of the smooth tracking test, 1/10 third stage and 2/10 forth stage disturbance. After dosages of 800 mg and 1200 mg there was a statistically significant difference disturbance of the smooth tracking test finding compared to control. After dosage of 800 mg of carbamazepine in 1/7 of volunteers the finding was without significant changes in the torsion chair test, in 3/7 changes were minimal, in 2/7 changes were moderate and in 1/7 of volunteers changes were high. In 5/10 of volunteers there was third stage of disturbance after dosage of 1200 mg of carbamazepine and in the same group 4/10 of volunteers had fourth stage of disturbance. In all cases after 800 mg and 1200 mg of carbamazepine pathologic vestibular habituation appeared. With increased dosage of carbamazepine the finding of the torsion chair test and smooth tracking test showed increased disturbance level. Disturbance of balance primary was on the central level and after higher therapeutic carbamazepine dose peripheral part of vestibular system disappeared.

Adult↗

PubMedDate not supplied

[Forensic significance of anomalies in skull development].

INTRODUCTION: In the course of bone tissue development some genetic disorders such as exostoses and enostoses, may occur. Exostoses and enostoses represent bone tissue hyperplasia that can develop at any part of skeleton. Neurotrauma can cause fatal biological consequences, which is directly associated with skill development abnormalities. CASE REPORT: This is a case report of a male cadaver 36 years of age. The autopsy revealed massive hemorrhage on the left side of the neck and the right side of the lower jaw. A major fissure of the arterial wall was found on the basilar artery. A bony, wart-like excrescence was found on the clivus of the occipital bone. DISCUSSION: Coinciding ruptures and consequential bleeding from basilar artery with presence of development abnormalities in the clivus region, suggest that one has to clearly distinguish the result of the injury from anomalies already existing in the skull. The position of the attacker can be determined by concise and objective investigation. CONCLUSION: This is a case report of an anomaly in bone development: a bony, wart-like excrescence on the right side of the clivus. Due to neurotrauma and consequential sliding of brain structures, the damage of basilar artery and of the bony excrescence occurred, which led to bleeding and fatal outcome.

Adult↗