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Biomedical subjects

Simon Clarke

Publications and source records attributed to Simon Clarke.

23 records · Page 2Linked to original sources

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Vomiting in paracetamol overdose.

A short cut review was carried out to establish whether vomiting was a significant consequence of paracetamol (acetaminophen) overdose. Altogether 48 papers were found using the reported search, of which two presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.

Acetaminophen↗

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Intravenous or intramuscular/subcutaneous naloxone in opioid overdose.

A short cut review was carried out to establish whether intramuscular/subcutaneous naloxone is better than intravenous naloxone in opioid overdose. Altogether 185 papers were found using the reported search, of which two presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.

Adult↗

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Discharge of patients who have taken an overdose of opioids.

A short cut review was carried out to establish whether patients with no recurrence of symptoms one hour after receiving naloxone for an opioid overdose can safely be discharged. Altogether 195 papers were found using the reported search, of which five presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.

Adult↗

Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Intravenous bolus or infusion of naloxone in opioid overdose.

A short cut review was carried out to establish whether intravenous boluses of naloxone are better than intravenous infusion in opioid overdose. Altogether 188 papers were found using the reported search, of which one presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of this best paper is tabulated. A clinical bottom line is stated.

Adult↗

On the generation of solitons and breathers in the modified Korteweg-de Vries equation.

We consider the evolution of an initial disturbance described by the modified Korteweg-de Vries equation with a positive coefficient of the cubic nonlinear term, so that it can support solitons. Our primary aim is to determine the circumstances which can lead to the formation of solitons and/or breathers. We use the associated scattering problem and determine the discrete spectrum, where real eigenvalues describe solitons and complex eigenvalues describe breathers. For analytical convenience we consider various piecewise-constant initial conditions. We show how complex eigenvalues may be generated by bifurcation from either the real axis, or the imaginary axis; in the former case the bifurcation occurs as the unfolding of a double real eigenvalue. A bifurcation from the real axis describes the transition of a soliton pair with opposite polarities into a breather, while the bifurcation from the imaginary axis describes the generation of a breather from the continuous spectrum. Within the class of initial conditions we consider, a disturbance of one polarity, either positive or negative, will only generate solitons, and the number of solitons depends on the total mass. On the other hand, an initial disturbance with both polarities and very small mass will favor the generation of breathers, and the number of breathers then depends on the total energy. Direct numerical simulations of the modified Korteweg-de Vries equation confirms the analytical results, and show in detail the formation of solitons, breathers, and quasistationary coupled soliton pairs. Being based on spectral theory, our analytical results apply to the entire hierarchy of evolution equations connected with the same eigenvalue problem. (c) 2000 American Institute of Physics.

Journal Article↗