Biomedical subjects

Shuichi Matsuda

Publications and source records attributed to Shuichi Matsuda.

42 records · Page 3Linked to original sources

PubMed2002

Solitary lymphangioma of the femur. A case report.

Lymphangioma of the bone is a benign lesion, characterized by newly formed lymph vessels. It usually occurs in a diffuse manner or as multiple lesions. Solitary lymphangioma of the bone is an extremely rare condition. We herein describe a case of solitary lymphangioma of the femur in a 55-year-old woman who presented with knee pain. Radiographs showed an eccentric osteolytic lesion in the distal femur. This is the first reported case of solitary lymphangioma of the bone occurring in the femur.

Biopsy, Needle↗

PubMed2002

Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: real-time semiquantitative assay by TaqMan polymerase chain reaction.

We screened for genetic alterations of adenomatous polyposis coli (APC) and beta-catenin genes in 17 frozen specimens from 12 cases of sporadic desmoid tumors and then subdivided these cases into two groups according to the results of mutational analysis. We further examined mRNA expression of beta-catenin and cyclin D1 by TaqMan PCR and compared the mRNA expression within both groups. Single-strand conformation polymorphism analysis followed by DNA direct sequencing revealed beta-catenin mutation in 3 of 12 cases (6 of 17 specimens), whereas no APC missense mutations in the mutation cluster region were found. TaqMan PCR revealed extremely higher mRNA expression of beta-catenin and cyclin D1 in desmoid tumors, compared with those of normal skeletal muscles. In the beta-catenin mutated group, cyclin D1 mRNA expression was significantly higher than that of the beta-catenin wild-type group (p = 0.0120, Mann-Whitney U test). In addition, in the beta-catenin mutated group, beta-catenin mRNA expression was also significantly higher than that of the beta-catenin wild-type group (p = 0.0036, Mann-Whitney U test). All cases of desmoid tumors showed detectable beta-catenin nuclear expression immunohistochemically. These results suggest that a continuously elevated beta-catenin protein level caused by the beta-catenin mutation itself may have a stronger power that can transactivate transcription in vivo. Furthermore, the results provide a possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors. This may suggest that the beta-catenin gene may be up-regulated by mutated or continuously elevated beta-catenin protein, that is, the beta-catenin gene may also be one of the targeted genes in the APC-beta-catenin-Tcf pathway.

Adolescent↗

PubMed2002

Factors affecting patellar tracking after total knee arthroplasty.

This study examined factors that influence patellar tracking after total knee arthroplasty. A total of 62 knees were evaluated radiographically for postoperative patellar tracking. Six factors were examined regarding their influence on postoperative patellar tracking. This study showed the effects of patellar component position, patellar resection angle, and lateral retinacular release on postoperative patellar tracking. There was no significant effect of the remaining 3 factors: the thickness of the patellar resection, preoperative patellar tilt, and rotational alignment of the femoral component. A medialized patellar component and obliquity of resection of the patella are effective for obtaining proper patellar tracking, whereas the evaluation of the influence of the external rotation of the femoral component requires more clinical studies.

Adult↗

PubMed2002

Patellar tracking and patellofemoral geometry in deep knee flexion.

Patellar tracking and femoral condylar geometry in deep knee flexion were evaluated using magnetic resonance imaging. The patellar tilting angle, patellar shift, and patellar anteroposterior translation from 0 degrees to 135 degrees flexion were measured. The depth of the femoral condylar articular surface and the curvature of the femoral condylar articular surface also were measured at 135 degrees flexion. The patella shifted laterally, tilted medially, and sank deeply into the intercondylar notch during deep knee flexion. The articular surface of the lateral condyle, existing deep within the intercondylar notch, began to curve steeply at a point farther from the center of the intercondylar notch than did the medial condyle. The geometry of the femoral condyle is adequate to fit the patellar geometry. Results of the current study suggest that the geometry of the lateral femoral condyle allows the patella to track smoothly with a larger patellofemoral contact area and less patellofemoral pressure during deep flexion.

Adult↗

PubMed2002

Primary lymphocutaneous nocardiosis caused by Nocardia otitidiscaviarum.

A case of primary lymphocutaneous nocardiosis caused by Nocardia otitidiscaviarum in a 69-year-old previously healthy woman is described. The organism was identified in cultures of pus specimens. The patient was treated with a six-month course of oral trimethoprim-sulfamethoxazole chemotherapy following incision and drainage, and the infection completely resolved.

Aged↗

PubMed2002

Changes in patellar tracking after total knee arthroplasty: 10-year follow-up of Miller-Galante I knees.

Changes in patellar tilt angle and patellar displacement were evaluated in 18 knees with the Miller-Galante I knee arthroplasty system (Zimmer, Warsaw, Ind). Mean follow-up was 10 years. Patellar tilt angle at final follow-up (5.7 degrees) was significantly larger than at 1 year postoperatively (2.8 degrees). Patellar displacement at final follow-up (5.1 mm) was significantly larger than at 1 year postoperatively (3.4 mm). Preoperatively, patellar tilt angle showed a statistically significant correlation with the change in tilting angle during follow-up. These results suggest patellar tracking can worsen during the long-term postoperative period.

Aged↗