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Shuichi Matsuda

Publications and source records attributed to Shuichi Matsuda.

At least 19 recordsLinked to original sources
PubMed2026

Machine learning-based clinical tool for identifying factors associated with symptomatic knee osteoarthritis: the Nagahama study.

BACKGROUND: A clinical tool that evaluates factors associated with symptomatic knee osteoarthritis (OA) based on modifiable factors is lacking. This study aimed to develop a machine learning-based clinical assessment tool using modifiable factors to identify factors associated with symptomatic knee OA and to determine its accuracy. METHODS: This study included 429 participants (81.8% women; age, 69.0&#xa0;&#xb1;&#xa0;5.3 years) from the Nagahama Study who were &#x2265;60&#xa0;years old and had radiographically confirmed knee OA. A Knee Society Knee Scoring System 2011 symptom score of <23 points defined symptomatic knee OA. Participants were randomly assigned to training (70%) and test (30%) datasets. A machine learning model was developed using Extreme Gradient Boosting with 27 variables, and the SHapley Additive exPlanation (SHAP) values were used to assess feature importance. The top 8 features were translated into a 100-point clinical scoring tool weighted by their SHAP contributions. The cutoff value indicating symptomatic knee OA in the clinical assessment tool was determined using receiver operating characteristic analysis, and model performance was evaluated in both datasets. RESULTS: The clinical assessment tool consisted of low back pain, OA severity, depressive tendencies, knee flexion/extension range of motion, knee extension and hip abduction strength, and lower limb muscle quality. The model showed moderate discriminative performance (AUC 0.771 and 0.773 in the training and test datasets, respectively), with a cutoff point of 47. CONCLUSION: The proposed clinical assessment tool may provide a structured framework for assessing modifiable factors associated with symptomatic knee OA, reflecting their contribution to current symptom status.

Humans↗
PubMed2006

Adventitial cystic disease of the popliteal vein: report of a case.

Adventitial cystic disease (ACD), also known as cystic mucoid or myxomatous degeneration, is a rare vascular disease seen mainly in arteries. It is very unusual for these cystic masses to develop in a vein. We report the case of a 56-year-old woman with leg swelling caused by ACD arising in the popliteal vein. The swelling appeared after a long period of standing. Magnetic resonance imaging (MRI) showed a popliteal cystic mass and venography showed disrupted venous flow. We resected the cyst wall without venous reconstruction, after which venous blood flow normalized and her symptoms subsided. To our knowledge, this is only the third documented case of ACD arising in the popliteal vein. A misdiagnosis could easily have been made, since the mass was not obvious on physical examination and the only symptom was intermittent swelling. Thus, it is important to be aware of ACD as a possible diagnosis when examining patients with a swelling in the leg.

Adult↗
PubMed2006

Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report.

BACKGROUND: G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. CASE PRESENTATION: We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma- or osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic bone. After hemipelvectomy, when local recurrence and metastasis were identified, leukocytosis appeared and an elevated level of serum granulocyte-colony-stimulating factor (G-CSF) was also recognized. The patient died of multiple organ failure 2 months after surgery. Autopsy specimens showed that the histological specimens of the recurrence and metastasis were dedifferentiated components, without any conventional chondrosarcoma components. G-CSF was expressed only in the dedifferentiated components, not in the chondrosarcoma components, immunohistochemically. CONCLUSION: This is the first report of chondrosarcoma, or any other primary bone tumor, with leukocytosis, probably stimulated by tumor-produced G-CSF from the dedifferentiated components.

Journal Article↗
PubMed2006

Asymmetry of mediolateral laxity of the normal knee.

BACKGROUND: Understanding the normal kinematics of the joints is important for reconstructive surgery. However, only a few extensive studies have been done on medial and lateral laxity of the normal knee. METHODS: Radiographs of 50 normal knees were obtained under varus and valgus stress in both extension and flexion and the relative angle of the articular surface was measured. RESULTS: In extension, the mean angle was 4.9 degrees in varus stress and 2.4 degrees in valgus stress. In flexion, the mean angle was 4.8 degrees in varus stress and 1.7 degrees in valgus stress. Lateral laxity was significantly greater than medial laxity in both extension and flexion. CONCLUSIONS: Lateral laxity may be necessary for the medial pivot movement of the normal knee. There is some disagreement regarding the importance of pursuing the perfect rectangular gaps during total knee arthroplasty (TKA). The methods for measuring the tension of soft tissues during the operation are not accurate and do not always reflect the postoperative tensions of dynamic phases, such as walking and standing. Slight lateral laxity can be accepted with TKA, and further studies are necessary to determine whether prosthesis lift-off occurs in the replaced knee with slight lateral laxity similar to that in the normal knee.

Adult↗
PubMed2006

Anteroposterior stability in posterior cruciate ligament-retaining total knee arthroplasty.

Anteroposterior stability was evaluated using a KT-2000 arthrometer in 18 patients (21 knees) continuously for up to 5 years after posterior cruciate ligament-retaining total knee arthroplasty. The Knee Society score, functional score, and the maximum flexion angle did not change significantly during the postoperative period. The mean anteroposterior displacement of all joints studied at both 30 degrees and 75 degrees of flexion did not change significantly during the 5-year period of observation, but 4 individual knees did exhibit increases in anteroposterior displacement of 3 mm or more. One of the 4 knees exhibited osteolysis beneath the tibial component. Three of these knees had undergone high tibial osteotomy at some time before the total knee arthroplasty.

Aged↗
PubMed2006

Arthroscopic resection of the discoid lateral meniscus: long-term follow-up for 16 years.

PURPOSE: Although the clinical outcome of arthroscopic resection for a torn discoid lateral meniscus is known to be successful in the short term, long-term successful results are necessary. We reviewed the clinical results of arthroscopic meniscectomy for a torn discoid lateral meniscus in 29 knees, with an average follow-up of 16 years. METHODS: Subjective symptoms were evaluated with the use of a questionnaire developed by the International Knee Documentation Committee (IKDC). The trends of IKDC scores and patient age at the time of surgery were statistically evaluated through a stepwise piecewise linear regression analysis. Radiographic examination was performed in 15 knees. RESULTS: The average IKDC score was 87 points. Statistical analysis conducted with the use of a regression model of scores revealed that the regression line declined from 90 to 72 points at ages between 25 and 30 years at the time of surgery. Radiographic examination revealed that patients with degenerative changes at the lateral joint compartment, such as joint space narrowing and subchondral sclerosis, were of greater average age at the time of surgery than did patients who did not develop these changes. CONCLUSIONS: Results suggest that clinical outcomes associated with this method are successful for longer than 10 years for patients younger than 25 years of age; however, older patients may develop problems caused by degenerative changes that may result from increased stress on the affected joint compartment. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

Adolescent↗
PubMed2006

Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patients.

Malignant peripheral nerve sheath tumor (MPNST) is an uncommon soft tissue neoplasm with a poor prognosis, occurring sporadically or associated with neurofibromatosis type 1 (NF1); however, the histogenesis of MPNST remains unclear, especially in sporadic tumors. There are two major forms of genomic instability in human cancer: chromosomal instability (CIN) and microsatellite instability (MSI). An inverse relationship has recently been demonstrated between CIN and MSI in colorectal cancers. CIN and MSI are suggested to be individual pathways, which are involved in the pathogenesis and which may lead to specific clinical and pathological characteristics. To elucidate the chromosomal aberration as a consequence of CIN and MSI status of MPNST, we karyotyped 10 MPNSTs from nine patients, and examined the MSI of seven microsatellite markers using high-resolution fluorescence microsatellite analysis; 2 out of 10 cases (20%) had normal karyotypes, and 8 out of 10 cases (80%) revealed structural and numerical chromosomal aberrations. Three of the 10 cases (30%) showed near triploidy. The most frequent aberration was -22 (40%), followed by +2, +14, -13, -17, and -18 (30% each). An MSI-low status was observed in 30% of cases; the remaining cases showed microsatellite stability. These findings suggest that chromosomal aberration as a consequence of CIN has a greater role in the pathogenesis of MPNST than does that due to MSI.

Adult↗
PubMed2006

Nuclear beta-catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcoma.

Nuclear beta-catenin staining in soft tissue sarcomas (STSs) has been shown to correlate with tumor progression as assessed by proliferative activity or poor prognosis. Frequent activation of Wnt signaling pathway has been also shown in synovial sarcoma (SS), suggesting a specific role of this pathway in SS. We examined roles of nuclear beta-catenin staining within soft tissue sarcomas. Immunohistochemical detection of nuclear beta-catenin accumulation correlated with cyclin D1 overexpression in spindle cell and pleomorphic sarcomas (P = .037), and the expression of these proteins evenly distributed throughout each section. In some cases, strong beta-catenin nuclear staining was observed in highly pleomorphic and mitotic cells. Furthermore, tumors with nuclear beta-catenin accumulation showed statistically significant increasing cyclin D1 mRNA expression level compared with those without (P = .023). Cyclin D1 mRNA expression levels were statistically higher in tumors with cyclin D1 overexpression than in tumors without (P = .037), suggesting that cyclin D1 overexpression is due to transcriptional activation. However, these correlations could not be detected in SS. In biphasic SS, beta-catenin nuclear staining was observed in spindle cells, whereas cyclin D1 nuclear staining was seen in glandular areas where beta-catenin kept membranous expression. Mutations in exon 3 of the beta-catenin gene and in the mutation cluster region of adenomatous polyposis coli gene were absent in this series of cases. Thus, cyclin D1 could be considered as one of the targets of the nuclear beta-catenin in spindle cell and pleomorphic sarcomas. A possible association between beta-catenin accumulation and spindle cell morphogenesis may exist in SS.

Cell Nucleus↗
PubMed2006

CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis.

The chemokine, CXCL12, and its receptor, CXCR4, have recently been shown to play an important role in metastasis of several kinds of carcinoma. It has also been demonstrated that VEGF regulates both the expression of CXCR4 and invasiveness in breast cancer cell lines. We compared the immunohistochemical expression of CXCR4 and VEGF between the primary site and a concordant pulmonary metastatic site in 30 osteosarcoma patients, all of which had undergone thoracotomy. Microvessel density (MVD) as shown by immunostaining of CD34 and proliferative activity with MIB-1 monoclonal antibody was also evaluated. CXCR4 expression (primary, 33.3% positive vs metastatic, 66.6% positive; P = 0.0097) and MVD (primary, 29.86 +/- 6.87/0.26 mm2 vs metastatic, 43.32 +/- 8.65/0.26 mm2; P = 0.0015) in the metastatic site were both significantly increased compared with those in the primary site, whereas no difference between primary and metastatic sites was observed with regard to VEGF expression. There was a significant positive correlation between immunohistochemical CXCR4 and VEGF expression (P = 0.0269). In total population, the MIB-1-labeling index (LI) was significantly higher in tumors, which showed immunoreactivity for VEGF (MIB-1-LI in VEGF-positive tumors, 24.29 +/- 5.4 vs VEGF-negative tumors, 18.33 +/- 4.16; P = 0.034). Furthermore, those patients with VEGF-positive primary tumors had a significantly worse prognosis compared with the patients with VEGF-negative primary tumors (P = 0.0053). Our results suggested that CXCR4 expression was associated with metastatic progression, and immunohistochemical VEGF expression in the primary site had predictive value for the osteosarcoma patients, who developed lung metastasis.

Adolescent↗
PubMed2006

The effect of ankle rotation on cutting of the tibia in total knee arthroplasty.

BACKGROUND: Extramedullary alignment guides are commonly used to prepare the tibia during total knee arthroplasty. One disadvantage is that the guide is easily affected by the position of the ankle joint. The tibia may have a rotational mismatch between its proximal and distal ends. We hypothesized that a rotational mismatch might cause incorrect positioning of an extramedullary alignment guide and evaluated such a mismatch on the predicted postoperative coronal alignment of the tibia. METHODS: Fifty-three osteoarthritic knees with varus deformity in fifty-one patients were evaluated with use of computerized tomography scans before total knee arthroplasty. We defined one anteroposterior axis of the ankle joint and five different anteroposterior axes of the proximal aspect of the tibia using three-dimensional bone models from the computerized tomography data. We measured the rotational angle between the anteroposterior axis of the ankle joint and the proximal part of the tibia. The distal end of the extramedullary guide was placed in front of the center of the ankle joint (on the line of the extended anteroposterior axis of the ankle joint), and the proximal end was placed on the line of the extended anteroposterior axis of the proximal part of the tibia. We established spatial coordinates to evaluate the effect of the rotational angle on the predicted postoperative coronal alignment of the tibia and calculated the presumed tibial coronal alignment. RESULTS: The rotational angle was positive (3.6 degrees to 19.7 degrees) for all of the anteroposterior axes of the proximal aspect of the tibia, indicating that the ankle joint was externally rotated relative to the proximal part of the tibia. The predicted tibial coronal alignment was varus (0.5 degrees to 5.1 degrees) for all of the anteroposterior axes of the proximal part of the tibia. CONCLUSIONS: When an extramedullary alignment guide is used to prepare the tibia in total knee arthroplasty, varus alignment of the tibial component can occur because of a rotational mismatch between the proximal part of the tibia and the ankle joint.

Aged↗
PubMed2006

The extramedullary guide of the proximal tibia resection should be seen straight in front during total knee arthroplasty.

If surgeons see the shaft of the extramedullary guide from lateral to the guide during preparation of the proximal tibia resection during total knee arthroplasty, the tibial component may be implanted in varus position in the frontal plane. In order to clarify the effect of the angle of the surgeons' sight relative to the sagittal plane and the posterior slope angle of the resected surface on varus position of the tibial component in the frontal plane, mathematical analysis was performed. Three-dimensional coordinate system was utilized so that the central axis of the tibial shaft on the Z-axis and the shaft of the guide were skew. The relationship between two lines was analyzed solving equations on three dimensional planes. When the posterior slope angle is 10 degrees, and if surgeons see the shaft of the guide 10 degrees, 20 degrees and 30 degrees lateral to the sagittal plane, and the shaft and the central axis of the tibial shaft would seem to be parallel, the true varus tilt angle of the shaft on the frontal plane is 1.8 degrees, 3.7 degrees and 5.8 degrees, respectively. The extramedullary guide should be seen straight in front of the guide.

Arthroplasty, Replacement, Knee↗
PubMed2006

Aneurysmal bone cyst of the capitate: case report and a review emphasizing local recurrence.

We herein report the case of a 15-year-old boy with cystic lesion of the capitate. Magnetic resonance imaging showed that the lesion demonstrated homogenous low-intensity on T1-weighted imaging and homogenous high intensity on T2-weighted imaging. The lesion was treated by curettage and autologous bone-grafting. The histological specimen from the cystic wall showed loose fibrous tissue with capillary vessels and extravasated red blood cells. The cystic lesion was filled with blood, suggesting that the cystic lesion was actually an aneurysmal bone cyst. The present case is the second reported case of aneurysmal bone cyst of the capitate. No recurrence has been observed during the 4 years since operation. We also review the literature related to ABCs of the hand with special emphasis on local recurrence.

Adolescent↗
PubMed2005

Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis.

In myxoid/round cell liposarcoma (MLS/RCLS), the presence of a round cell (RC) component has been reported to correlate with a worse prognosis for the patients. However, little is known about the molecular genetic differences between conventional myxoid (MX) components and RC components in this tumour. The aim of this study was to investigate the possible implications of molecular alterations of G1 to S-phase check-point genes, especially in the RC component. We evaluated the immunohistochemical expression of p53, MDM2, p14 and p16 protein and assessed proliferative activities using MIB-1 in 29 RC components and 81 MX components from 90 cases. Mutation of the p53 gene, amplification of the MDM2 gene, homozygous deletion, methylation status and mutation of the p16(INK4a)/p14(ARF) genes were also investigated, using concordant paraffin-embedded and frozen material. The data were analysed together with clinicopathological factors to assess their prognostic implications in MLS/RCLS. Immunohistochemically, the over-expression of p53 protein (p = 0.01366) and the reduced expression of p14 (p < 0.0001) and p16 (p < 0.0001) proteins were significantly more frequently observed in RC components than in MX components. Reduced expression of p14 protein correlated significantly with hypermethylation of the p14(ARF) gene promoter (p = 0.0176) and over-expression of p53 protein (p = 0.00837). By univariate analysis, reduced expression of p14 and p53 missense mutation were found to reduce the rate of survival significantly (p < 0.05). Multivariate analysis, including clinicopathological factors, revealed that tumour site (p = 0.0251), the presence of an RC component (p = 0.0113), high MIB-1 labelling index (p = 0.0005) and p53 missense mutation (p = 0.0036) were adverse prognostic factors. In MLS/RCLS, reduction of p14 protein expression and p53 mutation were related to poor prognosis. Accordingly, the p14(ARF)/p53 pathway may contribute to the presence of an RC component and malignant progression in this tumour.

Adolescent↗
PubMed2005

Five-year evolution of a telangiectatic osteosarcoma initially managed as an aneurysmal bone cyst.

We present the clinical, radiographic, and pathologic features of a telangiectatic osteosarcoma (TOS) of the right femoral neck in a 20-year-old man which was initially diagnosed and managed as an aneurysmal bone cyst (ABC). The lesion recurred twice. At the second recurrence TOS was diagnosed. The first local recurrence was recognized 4 years 8 months after the first operation. The clinical diagnosis for the recurrent lesion was recurrent ABC, and curettage and bone graft with internal fixation were performed. The second local recurrence was observed 8 months after the second surgery. The right lesser trochanter appeared destroyed on the radiograph, and a large medial soft tissue mass was demonstrated by computed tomography. The patient underwent wide resection of the tumor with prosthetic replacement of the right proximal femur. The histologic section for this lesion showed a blood-filled cystic lesion, and its wall contained sarcomatous cells with atypical mitoses and tumor osteoid. The histologic diagnosis for the second recurrent lesion was high-grade TOS. The retrospective review of the histologic section for the primary lesion showed similar features to ABC except for a few bizarre cells without mitosis in the tissue of cystic wall. The patient demonstrates no evidence of disease 13 months after the last surgery without adjuvant therapy (he declined chemotherapy).

Adult↗
PubMed2005

Importance of the lateral anatomic tibial slope as a guide to the tibial cut in total knee arthroplasty in Japanese patients.

Using three-dimensional computed tomography in 50 osteoarthritic knees, we simulated at various cutting angles the tibial cut for total knee arthroplasty. Cutting angles of 0 degrees, 3 degrees, 5 degrees, 7 degrees, 9 degrees, and 11 degrees were used. We then calculated the anterior and posterior thicknesses, the medial-lateral widths, and the medial and lateral condylar depths of the resected tibial bone at each cutting angle. Each set of measurements was evaluated according to a comparison between the cutting angle and the anatomic posterior slopes. The cutting angles showing the smallest anterior-posterior difference at the medial and lateral plateaus were 9 degrees and 7 degrees, respectively. The mean anatomic posterior slopes at the medial and lateral plateaus were 9.0 degrees and 8.1 degrees, respectively. When the tibia was cut at the cutting angle closest to the medial anatomical posterior slope in each knee, the thickness of the lateral posterior plateaus resected from 12 knees (24%) was more than 10 mm. Among these 12 knees, the cutting angle was more than 9 degrees in 9 knees (75%). In contrast, when the tibia was cut at the cutting angle closest to the lateral anatomical posterior slope, only one resected medial posterior plateau was more than 10 mm. The cutting angle of this case was 7 degrees. Therefore, in consideration of the thickness of bone resection from anatomic posterior slope, we demonstrated the importance of using the lateral anatomic posterior tibial slope as a guide to the tibial cut. There was no significant difference with respect to resected bone morphology at any cutting angle.

Aged↗