[Etiology of rheumatoid arthritis in an animal model].
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Animals↗
Biomedical subjects
Shimon Sakaguchi
Publications and source records attributed to Shimon Sakaguchi.
[T cell mediated immunoregulation and autoimmune disease].
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Abatacept↗
Regulatory T cells in immunologic self-tolerance and autoimmune disease.
Naturally arising CD25+ CD4+ regulatory T cells play key roles in the maintenance of immunologic self-tolerance and negative control of various immune responses. The majority, if not all, of them are produced by the normal thymus as a functionally distinct T-cell subpopulation, and their generation is in part developmentally controlled. Genetic abnormality in the development and function of this population can indeed be a cause of autoimmune disease, immunopathology, and allergy in humans. This regulatory population can be exploited to prevent and treat autoimmune disease by strengthening and reestablishing immunologic self-tolerance.
Antigens, CD↗