Biomedical subjects

Sherry L Murphy

Publications and source records attributed to Sherry L Murphy.

5 recordsLinked to original sources

PubMed2006

Deaths: final data for 2003.

OBJECTIVES: This report presents final 2003 data on U.S. deaths; death rates; life expectancy; infant and maternal mortality; and trends by selected characteristics such as age, sex, Hispanic origin, race, marital status, educational attainment, injury at work, State of residence, and cause of death. A previous report presented preliminary mortality data for 2003 and summarized key findings in the final data for 2003. METHODS: This report presents descriptive tabulations of information reported on death certificates, which are completed by funeral directors, attending physicians, medical examiners, and coroners. The original records are filed in the State registration offices. Statistical information is compiled into a national database through the Vital Statistics Cooperative Program of the Centers for Disease Control and Prevention's, National Center for Health Statistics (NCHS). Causes of death are processed in accordance with the International Classification of Diseases, Tenth Revision (ICD-10). RESULTS: In 2003, a total of 2,448,288 deaths were reported in the United States. The age-adjusted death rate was 832.7 deaths per 100,000 standard population, representing a decrease of 1.5 percent from the 2002 rate and a record low historical figure. Life expectancy at birth rose by 0.2 years to a record high of 77.5 years. Considering all deaths, age-specific death rates rose only for those 45-54 years and declined for the age groups 55-64 years, 65-74 years, 75-84 years, and 85 years and over. For the most part, the 15 leading causes of death in 2003 remained the same as in 2002. Heart disease and cancer continued to be the leading and second leading causes of death, together accounting for over half of all deaths. Homicide became the 15th leading cause in 2003, dropping from the 14th leading cause in 2002. Pneumonitis dropped out of the top 15 altogether, and Parkinson's disease entered the list as the 14th leading cause of death. The infant mortality rate in 2003 was 6.85 per 1,000 births. CONCLUSIONS: Generally, mortality patterns in 2003 were consistent with long-term trends. Life expectancy in 2003 increased again to a new record level. The age-adjusted death rate declined to a record low historical figure. The infant mortality rate decreased significantly in 2003; except for 2002, it either decreased or remained level each successive year from 1958 to 2003.

Adolescent↗

PubMed2004

Deaths: final data for 2002.

OBJECTIVES: This report presents final 2002 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, Hispanic origin, race, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life expectancy, and infant and maternal mortality are also described. A previous report presented preliminary mortality data for 2002. METHODS: In 2002 a total of 2,443,387 deaths were reported in the United States. This report presents descriptive tabulations of information reported on the death certificates. Funeral directors, attending physicians, medical examiners, and coroners complete death certificates. Original records are filed in the State registration offices. Statistical information is compiled into a national database through the Vital Statistics Cooperative Program of the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention. Causes of death are processed in accordance with the International Classification of Diseases Tenth Revision (ICD-10). RESULTS: The age-adjusted death rate for the United States in 2002 was 845.3 deaths per 100,000 standard population, representing a decrease of 1.1 percent from the 2001 rate and a record-low historical figure. Life expectancy at birth rose by 0.1-year to a record high of 77.3 years. Considering all deaths, age-specific death rates rose only for those under 1 year, and declined for a number of age groups including those 1-4 years, 25-34 years, 55-64 years, 65-74 years, 75-84 years, and 85 years and over. The 15 leading causes of death in 2002 remained the same as in 2001. Heart disease and cancer continued to be the leading and second leading causes of death, together accounting for over half of all deaths. The infant mortality rate in 2002 increased to 7.0 compared with a rate of 6.8 in 2001. CONCLUSIONS: Generally, mortality patterns in 2002 were consistent with long-term trends. Life expectancy in 2002 increased again to a new record level. The age-adjusted death rate declined to a record low historical figure. However, the infant mortality rate increased in 2002. The infant mortality rate has either decreased or remained level each successive year through 2001 since 1958. Trends for homicide and injury at work were interrupted due to the terrorist deaths that occurred September 11, 2001. The homicide rate decreased significantly from 2001 to 2002 and dropped to the 14th leading cause of death. Deaths due to injury at work also declined significantly during this period.

Cause of Death↗

PubMed2003

Deaths: final data for 2001.

OBJECTIVES: This report presents final 2001 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, Hispanic origin, race, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life expectancy, and infant and maternal mortality are also described. A previous report presented preliminary mortality data for 2001. METHODS: In 2001 a total of 2,416,425 deaths were reported in the United States. This report presents descriptive tabulations of information reported on the death certificates. Funeral directors, attending physicians, medical examiners, and coroners complete death certificates. Original records are filed in the State registration offices. Statistical information is compiled into a national database through the Vital Statistics Cooperative Program of the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention. Causes of death are processed in accordance with the International Classification of Diseases Tenth Revision (ICD-10). RESULTS: The age-adjusted death rate for the United States in 2001 was 854.5 deaths per 100,000 standard population, representing a decrease of 1.7 percent from the 2000 rate and a record low historical figure. Life expectancy at birth rose by 0.2 years to a record high of 77.2 years. Considering all deaths, age-specific death rates rose only for those 25-44 years, and declined for a number of age groups including those under 1 year, 5-14 years, 55-64 years, 65-74 years, 75-84 years, and 85 years and over. The 15 leading causes of death in 2001 remained the same as in 2000. Heart disease and cancer continued to be the leading and second leading causes of death, together accounting for over half of all deaths. Homicide became the 13th leading cause in 2001, rising from the 14th leading cause in 2000 as a result of the September 11, 2001, terrorist attacks. The infant mortality rate remained at a record low level, declining slightly but insignificantly from 6.9 in 2000 to 6.8 in 2001. CONCLUSIONS: Generally, mortality patterns in 2001 were consistent with long-term trends. Life expectancy in 2001 increased again to a new record level. The age-adjusted death rate declined to a record low historical figure. Although statistically unchanged from 2000, the trend in infant mortality has shown a steady, although slowing, decline. The declining trend in the homicide death rate was reversed primarily as a result of the September 11, 2001, terrorist attacks.

Adolescent↗

PubMed2003

Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif.

Regulation of pH in the central nervous system is critical to normal brain function and response to pathophysiological conditions. Here we identify two novel variants of the sodium-driven chloride bicarbonate exchanger (NCBE) from brain. The developmental expression pattern seen by in situ hybridization for the 90-bp containing insert (insert A) reveals strong expression in spinal cord and brain beginning in embryonic development. High-level expression is seen in cerebellar Purkinje cells and principal cells in hippocampus. The variant missing a 39-bp insert at the 3' end (insert B) encodes a protein in which the deduced carboxyterminal three amino acids are replaced with a unique 21 amino acid stretch terminating in a PDZ motif. rb2NCBE, the PDZ motif-encoding variant, is more highly expressed in astrocytes than is rb1NCBE. Both variants are expressed at similar levels in neurons. Expression varies with age and cell type. The FLAG epitope was fused in-frame at the amino terminus and each variant was expressed using a retroviral vector to study subcellular localization. Both variants were associated with the plasma membrane, but rb2NCBE colocalized with actin filaments to a greater extent, suggesting the PDZ form may interact with the cytoskeleton, whereas rb1NCBE was more often seen in intracellular vesicles. The PDZ motif-containing variant was much more active in pH regulation, with the expected ionic dependence on Na+, HCO3- and Cl- when expressed in 3T3 cells. These results are a first step towards understanding the regulation of expression and activity of this transporter in the brain.

3T3 Cells↗

PubMed2002

Deaths: final data for 2000.

OBJECTIVES: This report presents final 2000 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, Hispanic origin, race, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life expectancy, and infant and maternal mortality are also described. A previous report presented preliminary mortality data for 2000. METHODS: In 2000 a total of 2,403,351 deaths were reported in the United States. This report presents descriptive tabulations of information reported on the death certificates. Funeral directors, attending physicians, medical examiners, and coroners complete death certificates. Original records are filed in the State registration offices. Statistical information is compiled into a national database through the Vital Statistics Cooperative Program of the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention. Causes of death are processed in accordance with the Tenth Revision of the International Classification of Diseases (ICD-10). RESULTS: The age-adjusted death rate for the United States in 2000 was 872.0 deaths per 100,000 standard population, a decrease of 1.1 percent from the 1999 rate and a record-low historical figure. Life expectancy at birth rose by 0.2 year to a record high of 76.9 years. Considering all deaths, age-specific death rates rose only for those 45-54 years and declined for a number of age groups including those 1-4 years, 55-64 years, 65-74 years, 75-84 years, and 85 years and over. Fourteen of the 15 leading causes of death are the same for 1999 and 2000. Heart disease and cancer continued to be the leading and second leading causes of death, accounting for over one-half of all deaths when combined. Aortic aneurysm, which was the 15th leading cause of death in 1999, dropped from the list in 2000 and, in its place, Pneumonitis due to solids and liquids is the 15th leading cause of death. The infant mortality rate reached a record low value of 6.9 infant deaths per 1,000 live births, declining 2.8 percent from the infant mortality rate in 1999 (7.1 deaths per 1,000 live births). CONCLUSIONS: Generally, mortality continued long-term trends. The slight increase in the age-adjusted death rate that was experienced in 1999 reversed itself in accordance to a longer standing decreasing pattern. Life expectancy increased 0.2 years, and the infant mortality rate decreased statistically to a record low 6.9 deaths per 1,000 live births, thus maintaining the steady decline that has characterized it for the past four decades.

Adolescent↗