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Biomedical subjects

Shangkai Gao

Publications and source records attributed to Shangkai Gao.

At least 19 recordsLinked to original sources

A practical VEP-based brain-computer interface.

This paper introduces the development of a practical brain-computer interface at Tsinghua University. The system uses frequency-coded steady-state visual evoked potentials to determine the gaze direction of the user. To ensure more universal applicability of the system, approaches for reducing user variation on system performance have been proposed. The information transfer rate (ITR) has been evaluated both in the laboratory and at the Rehabilitation Center of China, respectively. The system has been proved to be applicable to > 90% of people with a high ITR in living environments.

Adult↗

[The sleep staging based on HRV analysis].

In order to deduce the sleep stages from heart rate, we analyze the heart rate variability (HRV) with hidden Markov model (HMM) for the identification of different characters of HRV within different sleep stages. Special technique is used to compensate the individual diversity. The relationship between the sleep stage and the ultra-low frequency components of HRV is also considered. Since the detection of heart rate hardly disturbs the sleep, the proposed method provides a simple approach to evaluating the sleep stage without disturbing the sleep. Our experiments have proved that this method meets the requirements of wide applications, especially the requirement of routine use in monitoring the normal subjects' sleep.

Adult↗

[Real-time and non-invasive temperature monitoring of thermotherapy using MRI].

High-intensity focused ultrasound (HIFU) thermotherapy is a promising technique for local tumor destruction of solid organs. Temperature is the important parameter which impacts the curative effects of thermotherapy. For safety and efficiency reasons, it is necessary to monitor the temperature changes inside body in real-time, non-invasively and precisely. Recently MRI methods employed for temperature monitoring during HIFU therapy have been paid more and more attentions to. This paper introduces the general principles of non-invasive temperature monitoring using MRI. The authors also review the development of this technique and point out some problems that need to be solved.

Animals↗

An epileptic seizure prediction algorithm based on second-order complexity measure.

The quality of life of many epilepsy patients may be improved significantly if the occurrence of epileptic seizures can be successfully forecasted and clinical intervention, such as electrical stimulation or drug delivery, can then be used to suppress their emergence, or warn the patient of the forthcoming events. In this paper, a prediction algorithm based on the second-order complexity measure was proposed to predict the impending seizures. Through the analysis of long-term intracranial EEG recordings from two frontal lobe epilepsy patients, the results indicated that the sensitivity of prediction was 77.8% (14/18) and 66.7% (4/6) and the number of false warnings was 3 and 2 for the two patients, respectively. Because only the information of past seizures was utilized to predict the current seizure and the computation load was low, the prediction algorithm could possibly be applied to clinical practice.

Adolescent↗

The relationship of HRV to sleep EEG and sleep rhythm.

Previous studies have shown that there exists a cycle of NREM (non-rapid eye movement)-REM (rapid eye movement) during normal human sleep, and heart rate variability (HRV) has a close relationship to sleep stages and sleep cycle. This article reports the relationship between the electroencephalographic activity and the HRV spectral power in several specific frequency bands. The authors discovered that relationships do exist between HRV and electroencephalogram (EEG) during sleep. In particular, it was found that, prior to the changes of EEG, the changes of HRV usually indicate the shift of sleep stages. HRV frequency analysis indicates that the very-low-frequency components of HRV are closely related to sleep EEG. Results show that the rhythm of the spectral power oscillations in some specific frequency bands of HRV is almost the same as the sleep cycle, which reflects the rhythm of sleep to a certain extent.

Adolescent↗

Standardized shrinking LORETA-FOCUSS (SSLOFO): a new algorithm for spatio-temporal EEG source reconstruction.

This paper presents a new algorithm called Standardized Shrinking LORETA-FOCUSS (SSLOFO) for solving the electroencephalogram (EEG) inverse problem. Multiple techniques are combined in a single procedure to robustly reconstruct the underlying source distribution with high spatial resolution. This algorithm uses a recursive process which takes the smooth estimate of sLORETA as initialization and then employs the re-weighted minimum norm introduced by FOCUSS. An important technique called standardization is involved in the recursive process to enhance the localization ability. The algorithm is further improved by automatically adjusting the source space according to the estimate of the previous step, and by the inclusion of temporal information. Simulation studies are carried out on both spherical and realistic head models. The algorithm achieves very good localization ability on noise-free data. It is capable of recovering complex source configurations with arbitrary shapes and can produce high quality images of extended source distributions. We also characterized the performance with noisy data in a realistic head model. An important feature of this algorithm is that the temporal waveforms are clearly reconstructed, even for closely spaced sources. This provides a convenient way to estimate neural dynamics directly from the cortical sources.

Action Potentials↗

Vitreous image enhancement in an ophthalmic sonographic imaging system using Golay coded excitation.

OBJECTIVE: The purpose of this study was to enhance the weak echoes of low reflective vitreous opacities on ophthalmic sonography. METHODS: A simulation study on a vitreous enhancement algorithm based on coded excitation was performed, with the analysis of the transmit efficiency and motion effects. On the basis of the simulation results, we have implemented a 10-MHz B-mode experimental sonographic platform with coded excitation. In the experimental platform, a field programmable gated array is used to apply a real-time signal-processing and imaging algorithm. RESULTS: A high-frequency ophthalmic sonographic imaging system based on Golay complementary sequence coded excitation is presented. The images of human eyes show appreciable improvement of the contrast resolution of low reflective vitreous opacities while suppressing the noise level. CONCLUSIONS: The images show the effectiveness of the vitreous enhancement algorithm and its potential clinical application.

Algorithms↗

[Coded excitation and its applications in medical ultrasound imaging].

Compared with medical ultrasonic pulse-echo imaging system, coded excitation system has the potential of higher SNR and deeper penetration depth. In this paper, the basic principle of coded excitation is introduced. Through acoustic intensity analysis, the maximum improvement of SNR of ultrasonic image with coded excitation is deduced. Then, guide lines to choose codes in ultrasonic imaging are introduced. Some codes, such as white noise, pseudo-random code, Golay code, Chirp and pseudo-chirp are described in details. At last, the applications of ultrasonic coded excitation in B-mode imaging, Doppler flow measurement, B-flow imaging and harmonics imaging are described.

Computer Simulation↗

Mu rhythm-based cursor control: an offline analysis.

OBJECTIVE: To classify the EEG data recorded in mu rhythm-based cursor control experiments with 4 possible choices. METHODS: The algorithm included preprocessing, feature extraction, and classification. Two spatial filters, common average reference and common spatial subspace decomposition, were used in preprocessing to improve the signal-to-noise ratio, and then two features were extracted based on the power spectrum and the time course of the mu rhythm respectively. A Fisher ratio was defined to select channels in feature extraction. A 2-dimensional linear classifier was trained for final classification. RESULTS: Two types of classifiers were trained for the training dataset. The uniform classifier gave a classification accuracy of 76.4%, and the classifier trained by leave-one-out method gave a classification accuracy of 74.4%, both higher than the online accuracy 69.5%. The uniform classifier was applied to the test dataset and the classification accuracy was 65.9%, lower than the online accuracy 73.2%. CONCLUSIONS: Spatial filtering can give a notable improvement in classification accuracy. The time course of the mu rhythm, as well as the power of the mu rhythm, shows difference between the 4 targets, and can contribute to the classification. SIGNIFICANCE: The spatial filtering, feature extraction and channel selection methods in the algorithm will provide some practical suggestions for further study on the mu rhythm-based brain-computer interface.

Algorithms↗

The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm.

The focal underdetermined system solver (FOCUSS) algorithm is a recursive algorithm to find the localized energy solution. It is an initialization-dependent algorithm. The generalized vector sample pattern matching (GVSPM) method has been applied to solve the inverse problem of electrical impedance tomography (EIT) and obtain smooth reconstructed images. By combining the GVSPM solution as the initial estimation of the FOCUSS algorithm, an idea termed the GVSPM-FOCUSS method is presented in this paper to improve the spatial resolution and precision of localization for EIT images. The comparisons are carried out between the EIT images reconstructed with the GVSPM-FOCUSS method and the GVSPM method alone. The effectiveness is verified by simulated and tank data for a model of a two-dimensional homogeneous circular disk.

Algorithms↗

Classification of single-trial electroencephalogram during finger movement.

We present an algorithm to discriminate between the single-trial electroencephalograms (EEG) of two different finger movement tasks. The method uses a spatio-temporal analysis to classify the EEG recorded during voluntary left versus right finger movement tasks. This algorithm produced a classification accuracy of 92.1% on the data from five subjects, without requiring subject training or data selection. This technique can be employed in an EEG-based brain-computer interface due to its high recognition rate, insensitivity to noise, and simplicity in computation.

Adult↗

BCI Competition 2003--Data set IV: an algorithm based on CSSD and FDA for classifying single-trial EEG.

This paper presents an algorithm for classifying single-trial electroencephalogram (EEG) during the preparation of self-paced tapping. It combines common spatial subspace decomposition with Fisher discriminant analysis to extract features from multichannel EEG. Three features are obtained based on Bereitschaftspotential and event-related desynchronization. Finally, a perceptron neural network is trained as the classifier. This algorithm was applied to the data set (self-paced 1s) of "BCI Competition 2003" with a classification accuracy of 84% on the test set.

Algorithms↗

BCI Competition 2003--Data set IIb: enhancing P300 wave detection using ICA-based subspace projections for BCI applications.

An algorithm based on independent component analysis (ICA) is introduced for P300 detection. After ICA decomposition, P300-related independent components are selected according to the a priori knowledge of P300 spatio-temporal pattern, and clear P300 peak is reconstructed by back projection of ICA. Applied to the dataset IIb of BCI Competition 2003, the algorithm achieved an accuracy of 100% in P300 detection within five repetitions.

Algorithms↗

A recursive algorithm for the three-dimensional imaging of brain electric activity: Shrinking LORETA-FOCUSS.

Estimation of intracranial electric activity from the scalp electroencephalogram (EEG) requires a solution to the EEG inverse problem, which is known as an ill-conditioned problem. In order to yield a unique solution, weighted minimum norm least square (MNLS) inverse methods are generally used. This paper proposes a recursive algorithm, termed Shrinking LORETA-FOCUSS, which combines and expands upon the central features of two well-known weighted MNLS methods: LORETA and FOCUSS. This recursive algorithm makes iterative adjustments to the solution space as well as the weighting matrix, thereby dramatically reducing the computation load, and increasing local source resolution. Simulations are conducted on a 3-shell spherical head model registered to the Talairach human brain atlas. A comparative study of four different inverse methods, standard Weighted Minimum Norm, L1-norm, LORETA-FOCUSS and Shrinking LORETA-FOCUSS are presented. The results demonstrate that Shrinking LORETA-FOCUSS is able to reconstruct a three-dimensional source distribution with smaller localization and energy errors compared to the other methods.

Algorithms↗

[Bone segmentation in human CT images].

In 3D visualization of human skeleton, distinguishing bones from soft tissue in 2D CT slides is the first and most critical procedure. This article presents the methods for image pre-processing, segmentation and smoothing. 1733 CT images of human body from Visible Human Project provided by the American National Library of Medicine are treated in this paper. We use the technique of Chebyshev uniform approximation filtering for denoising and present a new simple adaptive threshold method in segmentation, which combines the similarity of consecutive slices with the region-growing method. In post-processing, we use the algorithms of mathematical morphology and multi-resolution filtering. The accuracy of segmentation is examined and certified by comparing the segmented images with the original one. The results also demonstrate a wide applicability of the method.

Algorithms↗

[The progress in epileptic seizure prediction].

It is estimated that epilepsy, a chronic disorder of the nervous system, affects about 0.5%-2% of the population and about 10%-50% do not respond well to current antiepileptic medications and may not be candidates for surgery. For these patients, the unpredictability of seizure onset is a major cause of disability and mortality. Therefore, anticipation of an imminent seizure would be beneficial to patients because it could provide time for the application of preventive measures to keep the risk of seizure to a minimum. This paper reviews the feasibilities, the progress, existing problems and possible applications in the field of epileptic seizure prediction.

Algorithms↗

The application of the generalized vector sample pattern matching method for EIT image reconstruction.

This paper presents a new application of a generalized vector sample pattern matching (GVSPM) method for image reconstruction of conductivity changes in electrical impedance tomography. GVSPM is an iterative method for linear inverse problems. The key concept of the GVSPM is that the objective function is defined in terms of an angular component between the inner product of the known vector and solution of a system of equations. Comparisons are presented between images of simulated and experimental data, reconstructed using truncated singular value decomposition and GVSPM. In both cases, a normalized sensitivity matrix is constructed using the finite volume method to solve the forward problem.

Artifacts↗

A BCI-based environmental controller for the motion-disabled.

With the development of brain-computer interface (BCI) technology, researchers are now attempting to put current BCI techniques into practical application. This paper presents an environmental controller using a BCI technique based on steady-state visual evoked potential. The system is composed of a stimulator, a digital signal processor, and a trainable infrared remote-controller. The attractive features of this system include noninvasive signal recording, little training requirement, and a high information transfer rate. Our test results have shown that this system can distinguish at least 48 targets and provide a transfer rate up to 68 b/min. The system has been applied to the control of an electric apparatus successfully.

Algorithms↗