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Biomedical subjects

Selcuk Peker

Publications and source records attributed to Selcuk Peker.

5 recordsLinked to original sources
PubMed2006

Superficial siderosis due to papillary glioneuronal tumor.

Superficial siderosis of the central nervous system is a rare, progressive, irreversible and debilitating neurological disease characterized by the deposition of haemosiderin in the leptomeninges and the subpial layers of the brain and spinal cord. The main clinical findings are progressive bilateral sensorineural hearing loss, cerebellar ataxia and pyramidal tract signs. The present report describes a 49-year-old woman who presented with intermittent headache of 5 years duration. The pain had become more severe in the previous 6 months. Neurological examination revealed nothing abnormal. Computed tomography showed a cystic mass with apparent internal haemorrhage in the right frontal lobe and T(2)-weighted magnetic resonance imaging showed material of low signal intensity coating the entire surface of the brain. The mass was completely excised via craniotomy. A histopathological study identified the mass as a papillary glioneuronal tumour. The patient recovered well and is still neurologically normal 1 year later. This is the first documented case of superficial siderosis caused by this type of tumour.

Brain Neoplasms↗
PubMed2004

Irradiation after surgically induced brain injury in the rat: timing in relation to severity of radiation damage.

The aim of this study was to evaluate how timing of irradiation after brain surgery in rats relates to overall extent of brain radiation damage. Extent of injury was determined according to lipid peroxidation (malondialdehyde; MDA) levels in brain tissue. Thirty female rats were randomly assigned to five equal groups (Groups A-E). Four groups underwent trephination and scalpel hemisection of right frontal lobe. Rats in Groups B and D received 25 Gy cranial irradiation in a LINAC system at 10 and 20 days after surgery, respectively. Twenty-four hours later they were killed and their right frontal lobes were removed for lipid peroxidation determination. Groups A and C were not irradiated; these groups were killed and had their frontal lobes removed on day 11 and day 21 post-surgery, respectively. The remaining six animals (Group E, sham surgery) underwent trephination only, and were killed and had their frontal lobes removed 24 h later. There was a significant difference between the mean MDA levels in the control group and Group D, and between the levels in Group B and Group D (P < 0.05 for both). The difference between the mean for Group A and the mean for Group B was even more significant (P < 0.01). The most striking differences were between the control group and Group B, and between Group B and Group C (P < 0.001 for both). The data from this rat model suggest that, in humans, starting radiotherapy early (1-2 weeks) after debulking of a brain tumor may result in significantly higher levels of tissue damage than if the radiation is started 3 weeks or more postoperatively. Further experimental research is needed to project these findings in rats to human subjects.

Animals↗
PubMed2004

Surgical treatment of intramedullary spinal cord ependymomas: can outcome be predicted by tumor parameters?

OBJECTIVE: The aim of this study was to investigate whether the tumor parameters of spinal intramedullary ependymomas are significant predictors of clinical presentation and postsurgical outcome. METHODS: The study involved 21 cases of intramedullary ependymoma that were operated on between 1988 and 2001. The patients were 13 males (62%) and 8 females (38%), with an age range of 9-70 years (median 38 years). RESULTS: In most cases (13; 62%), preoperative neurologic examination revealed a sensorimotor deficit in at least one limb. Complete tumor removal was achieved in all cases. The patients with wider tumors had poorer preoperative neurologic condition and poorer neurologic outcome. Tumor length (equivalent to myelotomy length) was not correlated with preoperative neurologic status, but longer length was significantly associated with development of dysesthesia post surgery. In contrast to tumor length, tumor/cord ratio (ratio of the tumor width to the largest cord width at the tumor site) was identified as a significant predictor of preoperative neurologic status and outcome. Ratio values of >0.80 were correlated with poorer preoperative clinical status and poorer neurologic outcome. Neither extent of edema (determined from length [in millimeters] of hyperintensity on T2-weighted images) nor presence of a cyst in the tumor was significant relative to postoperative neurologic recovery in these cases. CONCLUSIONS: This study demonstrated that the width of the tumor relative to the cord is the main predictor of neurologic presentation and postoperative status. The length of the tumor affects the postoperative dysesthesia development.

Adult↗
PubMedDate not supplied

Trigeminal neuralgia due to pontine infarction.

Trigeminal neuralgia (TN) is most commonly caused by vascular compression of the trigeminal nerve root entry zone. Secondary trigeminal neuralgia due to ischemic lesion of the pons is very rare. Here we report a patient with a pontine infarct transecting the central trigeminal pathways resulting with trigeminal neuralgia.

Aged↗