Saurabh Asthana | Search PubMed

PubMed2005

A limited role for balancing selection.

Balancing selection has been shown to act on several genes in short-term evolutionary contexts, but it is not known whether this force is responsible for maintaining a significant number of long-term polymorphisms. We aligned 7628 chimpanzee virtual transcripts and 5524 chimp ESTs to the 4x chimp draft genome assembly and identified polymorphisms in chimpanzee that also occurred in the human single nucleotide polymorphism database (dbSNP). Our analysis suggests that the incidence of ancestral polymorphism is low or absent and that balancing selection on the time-scale of chimpanzee-human divergence has not been a significant force in human evolution.

Animals↗

PubMed2004

Predicting protein complex membership using probabilistic network reliability.

Evidence for specific protein-protein interactions is increasingly available from both small- and large-scale studies, and can be viewed as a network. It has previously been noted that errors are frequent among large-scale studies, and that error frequency depends on the large-scale method used. Despite knowledge of the error-prone nature of interaction evidence, edges (connections) in this network are typically viewed as either present or absent. However, use of a probabilistic network that considers quantity and quality of supporting evidence should improve inference derived from protein networks. Here we demonstrate inference of membership in a partially known protein complex by using a probabilistic network model and an algorithm previously used to evaluate reliability in communication networks.

Fungal Proteins↗