Images in cardiovascular medicine. Role of inflammation in atherosclerosis: immunohistochemical and electron microscopic images of a coronary endarterectomy specimen.
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Actins↗
Biomedical subjects
Sarah Kuruvilla
Publications and source records attributed to Sarah Kuruvilla.
Interleukin 2 receptor expression in renal biopsies and the diagnosis of acute allograft rejection.
The aim of the study is to test the diagnostic usefulness of assessing interleukin 2 receptor (IL2R) expression in infiltrating lymphocytes in renal biopsies from patients with suspected acute renal allograft rejection and to compare the NIH-CCTT and the Banff 97 systems of classifying the histopathologic changes in acute renal allograft rejection. The expression of interleukin 2 (IL2) and IL2R, as shown immuno-histochemically, is the final step in T cell mediated acute renal allograft rejection. Renal biopsies obtained from 40 patients clinically suspected to have early acute allograft rejection were examined histologically to diagnose acute allograft rejection and classified by the two systems. Frozen sections of the biopsies were stained with specific antibody for the presence of IL2R. 31 of the 40 patients were histologically and clinically confirmed to have acute allograft rejection. There was significant correlation with this diagnosis and the demonstration of IL2R on infiltrating lymphocytes. The CCTT system of grading correlated better with the presence of IL2R and the confirmed diagnosis of acute allograft rejection. The immunohistochemical demonstration of IL2R is a useful adjunct in the evaluation of biopsies suspected to show changes of acute cellular rejection. Since IL2 expression reflects the relative proportion of activated lymphocytes in the cellular infiltrate, it is proposed that the degree of IL2 expression may reflect the response of the use of monoclonal antibodies (Humanised/Chimaerised) as anti rejection therapy.
Adolescent↗
Renal abscess.
This study analyses the pre-disposing factors, diagnostic modalities, therapeutic options and prognostic factors involved in 7 subjects with renal abscess. Most often they presented with high fever and flank pain. USG and CT were used to establish the diagnosis. Urine culture yielded organisms in five cases and hence empirical antibiotic therapy for Gram-negative organism was offered. Complicated abscess in our series carried high mortality especially in immuno suppressed and cachectic patients.
Abscess↗
Fatty acid oxidation disorder as a cause of sudden infant death syndrome (SIDS)--a case report.
Although the cause of sudden infant death syndrome (SIDS) remains unknown, extensive studies over the last 10 years have begun to shed some light on this family tragedy. 5% of all cases of SIDS are caused by fatty acid oxidation disorders. We report a case of fatty acid oxidation disorder causing SIDS.
Consanguinity↗
Adrenocortical oncocytoma--a case report.
Oncocytic tumours of adrenal gland are rare lesions with approximately twenty-five cases being documented in literature. A majority of them are nonfunctional and benign. We report a case of adrenal oncocytoma in a 44-year-old male, who underwent a laparotomy for a large mass in the abdomen, which was located above the left kidney. Routine histopathological examination was suggestive of a benign tumour with cells resembling oncocytes. However, immunohistochemistry and electron microscopy helped to confirm the diagnosis of an adrenocortical oncocytoma.
Adenoma, Oxyphilic↗
Bilateral renal papillary necrosis due to Candida infection in a diabetic patient presenting as anuria.
A 38 years insulin-dependent diabetic male, with nephropathy on antituberculous treatment presented with painless frank hematuria followed by anuria for a day which was associated with fever. Ultrasonogram of the abdomen showed bilateral hydroureteronephrosis. Necrotic papillae were retrieved after ureteroscopy which on histopathological examination and culture showed Candida albicans. This was successfully treated with fluconazole and ureteroscopic removal of necrotic papillae.
Adult↗